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All Journal COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Cermin Dunia Kedokteran
Alfiandari, Dhini
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Humanities Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Social Sciences

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Mental Health and Depression in Indonesia: Risk Factors and Service Utilization for Healthy Aging Using SKI 2023 Data Wilaksono, Bhirau; Damry, Nurul Mufidah; Aminuddin, Nurul Mutiah; Alfiandari, Dhini
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 10 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

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Abstract

Mental health conditions, including depression, pose a significant public health challenge in Indonesia, impacting quality of life and healthy aging, particularly among vulnerable populations. This study examines the prevalence of depression and mental health issues, identifies associated risk factors, and evaluates disparities in health service utilization using secondary data from the 2023 Indonesian National Health Survey (SKI 2023). Logistic regression analysis was used to explore associations between mental health outcomes and sociodemographic factors, including age, gender, education, employment, and economic status. The analysis revealed significant geographic and demographic disparities. West Java reported the highest depression prevalence (3.3%) and Bali the lowest (0.3%). Women, unemployed individuals, and those in lower socioeconomic groups exhibited higher prevalence rates. Urban residents had greater access to services compared to rural populations, where stigma and resource limitations were prominent barriers. These findings highlight the urgent need for equitable, community-based mental health initiatives that integrate culturally sensitive care, address social determinants, and reduce stigma. Targeted policies and programs are essential to improving mental well-being, enhancing service accessibility, and supporting healthy aging across Indonesia's diverse populations.
AREDS2 sebagai Strategi Perlindungan Retina Terhadap Penuaan: Tinjauan Pustaka dari Perspektif Gerosains: Tinjauan Pustaka Wilaksono, Bhirau; Elfandari, Enno; Ichsan, Rayhani; Alfiandari, Dhini; Damry, Nurul Muf'idah; Chairul, Andi Makkawaru; Aminuddin, Nurul Mutiah; Nurdin, Novi Safitri; Chandrawati, Aida Ayu; Hammado, Nurussyariah
Cermin Dunia Kedokteran Vol 53 No 08 (2026): Agustus 2026
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i08.2130

Abstract

Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss among the elderly population. The Age-Related Eye Disease Study 2 (AREDS2) supplementation was developed as an evidence-based nutraceutical strategy to slow the progression of AMD. This review aims to evaluate the clinical evidence and potential application of AREDS2 as a geroprotective retinal intervention within the framework of precision geromedicine. Methods: A narrative review of recent AREDS and AREDS2 studies was conducted, integrating concepts from geroscience related to retinal aging. Results: The AREDS2 formulation, which replaced beta-carotene with lutein and zeaxanthin, demonstrated an 18% reduction in AMD progression risk without increasing lung cancer risk among smokers. AREDS2 components target key aging pathways, including oxidative stress, mitochondrial dysfunction, chronic inflammation, and dysregulated autophagy. In addition, potential modulation of mTOR and AMPK signaling suggests a role in extending retinal healthspan. Conclusion: AREDS2 represents a promising nutraceutical approach as a retinal gerotherapy within the paradigm of precision geromedicine. Its clinical implications include preventing AMD progression, optimizing visual function in older adults, and enabling integration into precision-based ophthalmologic practice. Further research is warranted to validate the molecular mechanisms and assess the cross-population effectiveness, thereby strengthening its role in broader age-related ocular health interventions.
Co-Authors Chairul, Andi Makkawaru Chandrawati, Aida Ayu Damry, Nurul Muf'idah Elfandari, Enno Hammado, Nurussyariah Nurdin, Novi Safitri Nurul Mufidah Damry Nurul Mutiah Aminuddin Rayhani Ichsan Wilaksono, Bhirau