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All Journal Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Pratama, Resta Ratna Juwita
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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DIAGNOSTIC TEST OF MOLECULAR RAPID TEST AGAINST REAL-TIME PCR ON DETECTING BCR-ABL CHRONIC MYELOID LEUKEMIA Pratama, Resta Ratna Juwita; Nurhayati, Betty; Merdekawati, Fusvita; Hayati, Eem; Ernawati, Ernawati
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 17 No 2 (2025): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/juriskesbdg.v17i2.2865

Abstract

Chronic Myeloid Leukemia (CML) is a condition characterized by abnormal proliferation of hematopoietic cells and can occur across various age groups. Detection of Breakpoint Cluster Region-Abelson (BCR-ABL) is essential to identify the presence of the Philadelphia chromosome (Ph 1 chr). Real-Time Polymerase Chain Reaction (Real-Time PCR) is the gold standard for BCR-ABL detection, but it has limitations such as long processing time and high cost. The Molecular Rapid Test (TCM) using the GenXpert platform offers a faster and more practical alternative. This study aimed to evaluate the performance of TCM BCR-ABL compared to Real-Time PCR. A cross-sectional design was applied with 54 samples obtained using consecutive sampling based on Lemeshow’s formula. The results showed a sensitivity of 91%, specificity of 90%, positive predictive value (PPV) of 94%, and negative predictive value (NPV) of 86%. Wilcoxon test analysis revealed no significant difference between the two methods (p=0.100). In conclusion, TCM demonstrates diagnostic performance comparable to Real-Time PCR and has the potential to be used as a rapid and efficient alternative for CML detection.
Co-Authors Ernawati Ernawati Hayati, Eem Merdekawati, Fusvita Nurhayati, Betty