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All Journal Sciences of Pharmacy Jurnal Pengabdian Kepada Masyarakat Kalam
Su’aida, Nily
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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Sosialisasi Penggunaan Antibiotik Yang Rasional Pada Pengunjung MTQ Kalsel 2023 Hasniah, Hasniah; Su’aida, Nily; Soemarie, Yulistia Budianti; Erlianti, Karina
Jurnal Pengabdian Kepada Masyarakat Kalam Vol. 3 No. 3 (2024): Pemberdayaan Potensi Masyarakat Untuk Peningkatan Kemampuan Hidup Sehat
Publisher : Prisani Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70704/jpk.v3i3.296

Abstract

Infectious diseases are one of the many health problems that occur in society, especially in Indonesia. The drugs commonly prescribed by doctors for the general public to overcome this problem are antibiotics. Antibiotics are drugs used by health to inhibit, kill or treat bacterial infections. However, the use of antibiotics is often misused, such as using antibiotics without a doctor's prescription, not finishing antibiotics, not using according to dosage, to treatment that should not require antibiotics. This poses a risk of antibiotic resistance. One of the factors causing this is the lack of education to the public regarding the use of drugs, especially antibiotics. The target of this activity is the people of South Kalimantan, precisely to the visitors of MTQ South Kalimantan 2023 where not a few of these people understand the use of antibiotics. This activity was carried out with the hope of educating the public about the use of good and correct antibiotics so as to prevent the development of antibiotic resistance. Based on the results of these activities, the people of South Kalimantan, namely visitors to MTQ South Kalimantan 2023, have received information on how to use antibiotics properly, correctly and rationally.
Natural Antidepressant Candidate from Cassia alata L. Ethanolic Extract: Behavioral (TST-FST) Evidence in Mice Putri, Kristina Srirahayu Damaiyanti; Nabella, Juwita Rosalia Sintia; Su’aida, Nily; Erlianti, Karina
Sciences of Pharmacy Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502577

Abstract

Cassia alata L. is a medicinal plant containing various secondary metabolites with reported neuroactive properties. This study aimed to evaluate the antidepressant-like behavioral effects of the ethanolic extract of Cassia alata Leaves in mice using acute behavioral despair tests. Male mice (n = 5 per group) were orally administered ethanolic extract of Cassia alata leaves at doses of 100, 200, and 400 mg/kg body weight. A sub-acute stress exposure protocol using the Tail Suspension Test was applied, and antidepressant-like activity was subsequently evaluated using the Forced Swimming Test, with immobility time at T2 as the primary outcome measure. Amitriptyline served as the standard drug. Data were analyzed using one-way ANOVA followed by Tukey’s HSD post hoc test (p0.05). Chemical profiling was performed using LC–MS/MS. One-way ANOVA revealed a significant difference in immobility time among groups (F (4,20) = 21.465, p0.001). Post hoc analysis showed that all extract-treated groups exhibited significantly lower immobility times compared to the negative control (p0.05). The highest dose (400 mg/kgBW) was not significantly different from amitriptyline (p0.05), while lower doses showed intermediate effects. LC–MS/MS analysis tentatively identified 17 compounds, including flavonoid derivatives, luteolin, and anthraquinones. Under the present experimental conditions, the ethanolic extract of Cassia alata leaves exhibited antidepressant-like behavioral activity in acute animal models. These findings are limited to short-term behavioral observations and do not establish clinical efficacy, safety, or underlying mechanisms. Further studies are required to clarify the pharmacological relevance and translational potential of this extract.
Co-Authors Erlianti, Karina Hasniah Nabella, Juwita Rosalia Sintia Putri, Kristina Srirahayu Damaiyanti Yulistia Budianti Soemarie