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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Cermin Dunia Kedokteran
Tamma, Haryadi Aristo
Unknown Affiliation
Health Professions Medicine & Pharmacology

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Literature Review: The Iceberg Phenomenon in Hyperthyroidism and Mental Disorders Dinata, Fenita Renny; Priskila, Loury; Danuartha, Made Anom; Tamma, Haryadi Aristo; Herlambang, Yosafat Reza
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i2.43494

Abstract

Background: Elevated thyroid hormone levels have a high prevalence this year. It has a long-term impact on the cognitive and productivity of sufferers, leading to a decrease in the quality of life of individuals and an increase in social and economic burden. Previous studies have shown a direct link between hyperthyroidism and mental disorders, but the impact on cognitive and emotional functioning still needs to be clarified. Early detection and management are the main challenges in preventing and treating this condition. Methods: Our study was a literature review of medical journal for the last 10 years through NCBI, Google Scholar, Clinicalkey, Semantic Scholar, Sciencedirect, and Springer. Result: Hyperthyroidism caused by dysregulation of the Hypothalamic-Pituitary-Thyroid axis that disrupts the balance of triiodothyronine and thyroxine hormones, leading to emotional and cognitive impairment. The brain and thyroid tissue are also affected by the FDPS, PPIL3, MMAB, and ALDH2 genes, which are characterized by significant expression in areas of brain function that are involved in cognitive, emotional, and social behaviour. Conclusion: A multidisciplinary approach, including pharmacological therapy, cognitive therapy, and community education, is an important step in reducing the impact of hyperthyroidism on mental health as well as social and economic aspects.
Safety and Efficacy of Lutein and Zeaxanthin in the AREDS2 Formulation for Age-Related Macular Degeneration: Literature Review Kristiyanto, Haryo Dimasto; Sira, Amaze Grace; Wibisana, Yosafat Reza Herlambang; Tamma, Haryadi Aristo; Danuartha, Made Anom
Cermin Dunia Kedokteran Vol 53 No 10 (2026): Oktober 2026 - CDK 357
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i10.2174

Abstract

Age-related macular degeneration (AMD) is a progressive degenerative disease of the central retina and is a leading cause of vision loss among older adults worldwide. The original Age-Related Eye Disease Study (AREDS) supplement formula reduced the risk of progression to advanced AMD. However, the beta-carotene in this formula was associated with a higher risk of lung cancer in current and former smokers. AREDS2 evaluated lutein and zeaxanthin as safer substitutes for beta-carotene. These macular carotenoids have antioxidant effects and a better safety profile. Studies show that lutein and zeaxanthin help slow AMD progression through antioxidant effects and retinoprotective mechanisms. Researchers have also studied genetic factors, including complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). However, current evidence is not strong enough to support individualized treatment based on these factors. Overall, lutein and zeaxanthin appear to provide a favorable balance of efficacy and safety as replacements for beta-carotene in the AREDS2 formulation.
Co-Authors Danuartha, Made Anom Dinata, Fenita Renny Herlambang, Yosafat Reza Kristiyanto, Haryo Dimasto Priskila, Loury Sira, Amaze Grace Wibisana, Yosafat Reza Herlambang