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All Journal Indonesian Journal of Chemistry Pharmaceutical Sciences and Research (PSR) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Fachri, Wilzar
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Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Neuroscience Public Health

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Advancing Herbal Medicine: The Role of Nanosomal Technology in Treating Skin Diseases Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Herbal medicine has become popular worldwide, especially in developing countries, with around 80% of the population opting for herbal treatments. The perceived benefits of natural remedies, such as affordability and fewer side effects, drive this trend. Herbal therapies effectively manage skin diseases, infections, and common ailments. However, the absorption of bioactive compounds in herbal extracts is often limited. Recent developments in nano-based herbal delivery systems, like nanosomal, show promise in enhancing the efficacy of herbal remedies for topical applications, providing improved solubility, stability, and skin penetration. This review describes various nanosomal studies developed and successfully used to enhance the topical delivery of natural compounds, including liposomes, ethosomes, transfersomes, transethosomes, phytosomes, and niosomes.
Quantitative Flavonoids and Antioxidant Profiles by DPPH Assay of Centella Asiatica Serum Cosmetic Products Versus Ethanol Extract Habibie, Sutan Farrell; Dwijayanti, Adisti; Fachri, Wilzar
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.326

Abstract

The cosmetic industry is currently leaning toward herbal skincare products due to strong consumer preference for natural ingredients. Centella asiatica (CA) is frequently used as it contains flavonoids and centelloids known for their beneficial antioxidant properties. This study aimed to assess the efficacy of CA extract when incorporated into cosmetic formulations by comparing the total flavonoid content (TFC) and antioxidant activity of five commercial serums (A-E) against a pure CA ethanol extract. The experimental study was conducted in vitro, utilizing the CA extract, Vitamin C (as a positive control), and the five commercial serum products. TFC was determined quantitatively using UV-Visible spectrophotometry and quercetin standard. Antioxidant activity was measured using DPPH assay to calculate the IC50 value. Pure CA extract showed a mean TFC of 37.10 ± 0.21 mg QE/g, with serum samples showing high variability; the highest being Sample C with a TFC of 216.6 (99.89 - 246.1) mg QE/g and the lowest being sample E with a TFC of 24.75 ± 1.88 mg QE/g. Crucially, the pure CA extract demonstrated strong antioxidant activity with a mean IC50 of 52.45 ± 4.96 ppm. In contrast, all serum products exhibited significantly weaker antioxidant activities. Samples C and D resulted in extremely high IC50 values of 244100 ± 116700 ppm and 319300 ± 95700 ppm respectively, categorized as lower than weak, while samples A, B, and E were unable to reach 50% inhibition, indicating an antioxidant capacity below the measurable range. In conclusion, despite the pure Centella asiatica ethanol extract showing robust antioxidant activity, the commercial cosmetic serums demonstrated a significantly lower range of activity and highly inconsistent TFC, suggesting that the raw extract's potency does not reliably transfer to the final product formulation.
Simultaneous HPLC Analysis of Asiaticoside and α-Mangostin in Nanoethosomal Carriers Aswan, Pedro Anugerah; Maggadani, Baitha Palanggatan; Fachri, Wilzar; Iswandana, Raditya
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.111150

Abstract

The development of robust analytical methods is essential for quality control of nanoethosomal formulations containing asiaticoside and α-mangostin, bioactive compounds with anti-inflammatory and antioxidant properties. Simultaneous quantification within nanocarriers is challenging and requires validated techniques. This study established a precise HPLC method, in accordance with ICH Q2(R2) guidelines, for the concurrent determination of both compounds. The technique demonstrated excellent linearity (R2 > 0.999), precision (%RSD < 2%), and accuracy (95–105% recovery). The nanoethosomal system also achieved high encapsulation efficiencies of 94.76% for asiaticoside and 99.27% for α-mangostin. This validated method provides a reliable tool for standardizing these complex nano-formulations, supporting their further development and clinical translation.
Co-Authors Adisti Dwijayanti Aswan, Pedro Anugerah Baitha Palanggatan Maggadani, Baitha Palanggatan Habibie, Sutan Farrell Raditya Iswandana