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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Buana Farma
Pujianti, Ayu
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Evaluation of Chitosan as a Natural Disintegrant in the Formulation of Aspirin Orally Disintegrating Tablets nawangsari, Desy; Alfianto, Hazim Fikri; Pujianti, Ayu; Rahmawati, Nur; Kadarani, Deva Krisna
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.128-137.2025

Abstract

Aspirin is an antiplatelet that is used for the therapy and prevention of stroke, many strokes occur in elderly people. Orally Disintegrating Tablet (ODT) can be dissolved quickly making it easier for geriatric patients to swallow. This study aims to determine the effect of variation in the concentration of chitosan as a disintegrating agent on the physical properties of ODT aspirin. Aspirin ODT tablets were produced by direct compression in 3 formulas with variations of chitosan of 3.5%, 7% and 14%. The results showed that a chitosan concentration of 3.5% yielded optimal tablet properties: disintegration time of 23.66 seconds, friability of 0.41%, and dissolution of 96.81%. Statistically significant differences (p < 0.05) were observed among the formulations in terms of in hardness (p = 0.027), friability (p = 0.010) and disintegration time (p = 0.000). The disintegration mechanism of chitosan involves swelling, wicking, and strain recovery. At lower concentrations, chitosan promotes rapid water uptake and particle expansion, facilitating fast breakdown of the tablet matrix. In contrast, higher chitosan levels may induce gel formation that hinders water penetration, thus delaying disintegration. In conclusion, chitosan at a concentration of 3.5% effectively functions as a natural disintegrant in aspirin ODTs, offering rapid disintegration and high dissolution, which is suitable for geriatric patients with swallowing difficulties.
OPTIMASI FORMULA DAN EVALUASI MASSA CETAK TABLET HISAP BERBAHAN YOGURT DENGAN METODE SIMPLEX LATTICE DESIGN Pujianti, Ayu; Nawangsari, Desy; Febrina, Dina
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1558

Abstract

Yocanserah® yogurt contains peanuts, ginger, and lemongrass, which have potential anti-diabetic properties. Yocanserah has a limited shelf life and sour taste, so it needs to be developed into a more acceptable lozenge formulation with a longer shelf life. The purpose of this study is to optimize the formulation of yogurt-based lozenge tablets using the simplex lattice design method. The materials or factors used in the optimization were Avicel PH 102, isomalt, and SSG, with the response being flow rate and compressibility. The data were analyzed using Design Expert software with the simplex lattice design method. The yogurt-based lozenge tablet mass was made using the wet granulation method with gelatin solution as a binder. The results showed that the tablet mass with variations in Avicel PH 102, isomalt, and SSG made using the wet granulation method produced flow rate and compressibility in accordance with the specifications. The use of variations in these three ingredients had a significant effect on the flow rate and compressibility of the tablet mass with a p-value < 0.05. The optimal formula for yogurt-based lozenge molding mass was obtained with a proportion of 49% Avicel PH 102, 1% isomalt, and 5% SSG, which produced a flow rate of 5.58 g/s and compressibility of 6.69% with a resulting desirability value of 0.311.
Co-Authors Alfianto, Hazim Fikri Deva Krisna Kadarani Dina Febrina Nawangsari, Desy Nur Rahmawati