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All Journal Heart Science Journal Hang Tuah Medical Journal
JOVIE, BENNY
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Latihan Submaksimal dalam Hiperbarik-Hiperoksia dan Perubahan Fraksi Ejeksi pada Subjek Sehat JOVIE, BENNY; PRATIKNYA, DJATIWIDODO EDI; KURNIAWAN, I MADE PRASETYA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.875

Abstract

Coronary artery disease (CAD) is a leading cause of global morbidity and mortality. An important parameter in assessing left ventricular function is the ejection fraction (EF), which reflects the heart's ability to effectively pump blood into the systemic circulation. In recent decades, hyperbaric oxygen therapy (HBOT) has attracted attention as a non-pharmacological adjunct modality in the management of ischemic heart disease. The type of research is a true experimental research design with a randomized control group pretest - posttest with a sampling technique used is simple random sampling. The population in this study were 30 soldiers from the Surabaya Marine Corps Health Corps. In this experiment in both groups, the results obtained were p<0.05, which means that there is a difference in the pre and post results. When performing submaximal exercise in a hyperbaric-hyperoxic environment, cardiovascular adaptations occur, namely changes in afterload, preload, and myocardial oxygenation. Increased PaO₂ and dissolved oxygen can increase in stroke volume so that LVEF can appear to increase depending on the patient's baseline status. The conclusion of this study shows that submaximal exercise in hyperbaric-hyperoxy conditions provides better results and can even provide results that show normal results.
Latihan Submaksimal dalam Hiperbarik-Hiperoksia dan Perubahan Fraksi Ejeksi pada Subjek Sehat JOVIE, BENNY; PRATIKNYA, DJATIWIDODO EDI; KURNIAWAN, I MADE PRASETYA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.875

Abstract

Coronary artery disease (CAD) is a leading cause of global morbidity and mortality. An important parameter in assessing left ventricular function is the ejection fraction (EF), which reflects the heart's ability to effectively pump blood into the systemic circulation. In recent decades, hyperbaric oxygen therapy (HBOT) has attracted attention as a non-pharmacological adjunct modality in the management of ischemic heart disease. The type of research is a true experimental research design with a randomized control group pretest - posttest with a sampling technique used is simple random sampling. The population in this study were 30 soldiers from the Surabaya Marine Corps Health Corps. In this experiment in both groups, the results obtained were p<0.05, which means that there is a difference in the pre and post results. When performing submaximal exercise in a hyperbaric-hyperoxic environment, cardiovascular adaptations occur, namely changes in afterload, preload, and myocardial oxygenation. Increased PaO₂ and dissolved oxygen can increase in stroke volume so that LVEF can appear to increase depending on the patient's baseline status. The conclusion of this study shows that submaximal exercise in hyperbaric-hyperoxy conditions provides better results and can even provide results that show normal results.
A potential coronary angiographic burden estimation (CABE) index based on age, fasting blood glucose, and atherogenic index of plasma Zenjaya, Kellyn Trycia; Priscilla, Kezia Rachel; Velisia, Maria Angela; Sukmawati, Sang Ayu Putu Wulan; Aditama, Dedi; Jovie, Benny; Diarsvitri, Wienta
Heart Science Journal Vol. 7 No. 4 (2026): Navigating High-Risk Cardiovascular Subsets: Premature Disease, Plaque Complexi
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.04.11

Abstract

Background: Coronary artery disease remains a major contributor to morbidity and mortality worldwide. Simple and accessible tools for estimating coronary angiographic disease burden may facilitate risk stratification, particularly in settings with limited resources.Objective: To develop and temporally internally validate a practical index for estimating coronary angiographic disease burden using routinely available clinical and metabolic parameters.Methods:  We retrospectively analyzed medical records of 414 patients for model derivation and 166 patients for temporal internal validation, who underwent coronary angiography at Dr. Ramelan Naval Central Hospital between 2024 and 2025. Angiographic burden was classified as mild (Gensini score <11) or moderate-to-severe (≥11). Candidate predictors were  evaluated using logistic regression, and model performance was assessed  using receiver operating characteristic (ROC) analysis.Result: Older age, higher fasting blood glucose (FBG), and atherogenic index of plasma (AIP) were independently associated with greater CAD burden (all p < 0.05), and were incorporated into the Coronary Angiographic Burden Estimation (CABE) Index. The model demonstrated fair discrimination in the derivation cohort (AUC 0.726;60.5% sensitivity and 73.2% specificity at the predefined cutoff) and showed consistent performance in the temporal validation cohort (AUC 0.729). Conclusion: The CABE index is a simple, association-based tool that estimates the likelihood of higher coronary angiographic burden using routinely available clinical and metabolic parameters. . The index demonstrated fair discrimination and consistent temporal validation performance. Further external multicenter validation is required before its broader application in clinical decision-making.
Co-Authors Aditama, Dedi Djatiwidodo Edi Pratiknya I Made Prasetya Kurniawan Kurniawan, I Made Prasetya Priscilla, Kezia Rachel Sukmawati, Sang Ayu Putu Wulan Velisia, Maria Angela Wienta Diarsvitri Zenjaya, Kellyn Trycia