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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Hang Tuah Medical Journal
I Made Prasetya Kurniawan
Hang Tuah University
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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The Effect of Thespesia populnea Against Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase Receptor by Study In Silico I Made Prasetya Kurniawan; Prawesty Diah Utami; Risma Risma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5368

Abstract

Indonesia is a country that has abundant natural resources; one of them is the Baru laut plant which is the latest breakthrough because it has an active substance that can be used as an anti-malaria medicine. It is very beneficial because there has been a case of resistance of artemisinin derivatives in Indonesia. The purpose of this study was to determine the potential of active compounds in Baru laut plants (Thespesia populnea (L.) Soland ex. Correa) against the Plasmodium falciparum enoyl acyl carrier protein reductase receptor in P. falciparum through in silico studies. This research is purely experimental using the One-Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely prediction analysis of active compound content, prediction analysis of the mechanism of action of active compound content, and prediction analysis of ADME active compound. The study results show that there are three active compounds in Baru laut plants that have antimalarial potential. The three compounds include gossypol, linoleic acid, and beta-sitosterol, have their respective potential in becoming a malaria drug. This study concludes that Baru laut plants have potential as anti-malaria drugs.
Latihan Submaksimal dalam Hiperbarik-Hiperoksia dan Perubahan Fraksi Ejeksi pada Subjek Sehat JOVIE, BENNY; PRATIKNYA, DJATIWIDODO EDI; KURNIAWAN, I MADE PRASETYA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.875

Abstract

Coronary artery disease (CAD) is a leading cause of global morbidity and mortality. An important parameter in assessing left ventricular function is the ejection fraction (EF), which reflects the heart's ability to effectively pump blood into the systemic circulation. In recent decades, hyperbaric oxygen therapy (HBOT) has attracted attention as a non-pharmacological adjunct modality in the management of ischemic heart disease. The type of research is a true experimental research design with a randomized control group pretest - posttest with a sampling technique used is simple random sampling. The population in this study were 30 soldiers from the Surabaya Marine Corps Health Corps. In this experiment in both groups, the results obtained were p<0.05, which means that there is a difference in the pre and post results. When performing submaximal exercise in a hyperbaric-hyperoxic environment, cardiovascular adaptations occur, namely changes in afterload, preload, and myocardial oxygenation. Increased PaO₂ and dissolved oxygen can increase in stroke volume so that LVEF can appear to increase depending on the patient's baseline status. The conclusion of this study shows that submaximal exercise in hyperbaric-hyperoxy conditions provides better results and can even provide results that show normal results.
Co-Authors JOVIE, BENNY Pratiknya, Djatiwidodo Edi Prawesty Diah Utami RISMA