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All Journal Sehat Rakyat: Jurnal Kesehatan Masyarakat
Antonius Christanto
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Systematic Review: Peran Sel, Jaringan, dan Kolagen dalam Penyembuhan Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 4 No. 4 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v4i4.5771

Abstract

Tympanic membrane perforation is a significant clinical concern that can lead to hearing impairment and recurrent ear infections. This study aims to review the roles of Interleukin-1 beta (IL-1β), Fibroblast Growth Factor (FGF), fibroblasts, keratinocytes, granulation tissue, and collagen density during the wound-healing phases of the tympanic membrane.A Systematic Journal Review was conducted by analyzing studies retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar databases published between 2020 and 2025. Of the 400 records screened,, 10 studies met the inclusion criteria. The findings revealed that IL-1β plays a key role in the inflammatory phase by modulating immune responses and recruiting healing cells. FGF stimulates fibroblast and keratinocyte proliferation, which are essential for extracellular matrix (ECM) remodeling and re-epithelialization. Moreover, granulation tissue formation and collagen deposition are critical determinants of structural integrity and healing quality. Overall, tympanic membrane repair requires synergistic interactions among molecular mediators, cellular components, and biomaterial support to optimize tissue regeneration. These findings provide a scientific basis for developing more effective regenerative and tissue-engineering strategies for middle ear therapy.
Keunggulan L-PRF Dibandingkan P-PRF, PRFM, A-PRF, & I-PRF sebagai Cangkok pada Operasi Miringoplasti: Studi Penyembuhan Luka pada Perforasi Membran Timpani Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i1.6020

Abstract

This study aims to analyze the advantages of Leukocyte-Platelet Rich Fibrin (L-PRF) application in myringoplasty surgery compared to other platelet concentrates such as Platelet-Rich Fibrin Membrane (PFRM), Advanced Platelet-Rich Fibrin (A-PRF), and Injectable Platelet-Rich Fibrin (I-PRF). The research method used is a qualitative literature review, collecting and analyzing data from recent scientific journals and clinical studies related to the use of L-PRF in tympanic membrane repair. The study finds that L-PRF, with its dense fibrin network and high content of leukocytes and growth factors, enhances tissue regeneration, angiogenesis, and epithelialization, which are critical for successful graft integration and faster healing after myringoplasty. Compared to other platelet concentrates, L-PRF offers better mechanical strength and a more sustained release of growth factors. Additionally, L-PRF reduces postoperative complications and improves hearing outcomes. Being an autologous biomaterial, it also reduces the risk of immune rejection. The findings suggest that L-PRF is a promising graft material in otologic surgery, though further clinical trials are needed to optimize its application protocols.
Co-Authors Made Setiamika Paramasari Dirgahayu Ratih Dewi Yudhani Risya Cilmiaty