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All Journal Justek : Jurnal Sains Dan Teknologi Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Kesehatan Kusuma Husada
Patricia, Gaby Ayu
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Optimization of the Combination Ratio of Biduri and Bidara Leaf Extracts in Reducing Cholesterol in Mice Rifqiyah, Jazilatur; Wijayanti, Cicik; Patricia, Gaby Ayu; Yusmiati, Siti Nur Husnul; Ngibad, Khoirul
Justek : Jurnal Sains dan Teknologi Vol 8, No 4 (2025): December
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v8i4.36437

Abstract

This study aimed to evaluate the effectiveness of a combination of ethanol extracts of Biduri (Calotropis gigantea L.) and Bidara (Ziziphus spina-christi L.) leaves in reducing cholesterol levels in mice induced with hypercholesterolemia, as well as to determine the optimal dose and combination ratio. This experimental laboratory study involved several stages, including extract preparation, preparation of extract suspensions, preparation of simvastatin and propylthiouracil (PTU) suspensions, selection and maintenance of experimental animals, administration of treatments, and measurement of blood cholesterol levels. A total of 72 male mice were divided into 12 treatment groups: negative control, positive control, drug control, and nine groups receiving combinations of extracts with ratios of 1:1, 1:2, and 2:1 at three doses (14, 28, and 56 mg/20 g BW). Hypercholesterolemia was induced using PTU for 14 days, followed by oral administration of the extract combinations for 3 days. Cholesterol levels were measured using a spectrophotometer and analyzed using One Way ANOVA. The results showed that the combination of Biduri and Bidara extracts significantly reduced cholesterol levels (p < 0.05), with the highest reduction observed in the 2:1 ratio at a dose of 56 mg/20 g BW, showing a 59.18% decrease (135.47 mg/dL) compared to the positive control. These findings indicate a synergistic effect between the two extracts and suggest their potential as a natural hypocholesterolemic agent.
Antihypercholesterolemic Activity of the Ethanol Extract Combination of Leaves Calotropis gigantea L. and Adenanthera pavonina L. Oktaviani, Galuh Anggun; Patricia, Gaby Ayu; Wijayanti, Cicik; Ngibad, Khoirul
Justek : Jurnal Sains dan Teknologi Vol 8, No 4 (2025): December
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v8i4.36441

Abstract

Hypercholesterolemia is a significant risk factor for cardiovascular disease, and its prevalence continues to increase. Pharmacological therapy using statins is effective but may cause side effects when used long-term. Therefore, exploring natural ingredients as an alternative antihypercholesterolemic therapy is essential. This study aimed to evaluate the activity of a combination of ethanol extracts of Calotropis gigantea L. leaves and Adenanthera pavonina L. on the cholesterol levels of male mice induced with propylthiouracil (PTU). The study was conducted experimentally using a post-test-only control-group design with 36 male mice divided into six groups: negative control, positive control, drug control (simvastatin), and three treatment groups receiving extract combinations at doses of 14, 28, and 56 mg/g BW. The research stages included seven days of animal adaptation, induction of hypercholesterolemia with PTU for 14 days, administration of the extract combination at doses of 14, 28, and 56 mg/g BW for four days, and blood sampling for total cholesterol measurement using an automated chemical spectrophotometer. The results showed a significant increase in cholesterol levels in the positive control group, while simvastatin produced the most significant reduction. The extract combination gradually decreased cholesterol levels with increasing dose, with the highest dose approaching the effect of simvastatin. The paired t-test showed a p-value < 0.05, indicating significant differences between treatments. The combination of Calotropis gigantea L. and Adenanthera pavonina L. leaf extracts has potential as a herbal agent to support antihypercholesterolemic therapy.
THE POTENTIAL OF COMBINED ETHANOL EXTRACTS OF SAGA AND SEMBUKAN LEAVES IN REDUCING CHOLESTEROL LEVELS IN HYPERCHOLESTEROLEMIC MICE Fadila, Ulfatul; Patricia, Gaby Ayu; Ngibad, Khoirul
Jurnal Kesehatan Kusuma Husada Vol. 17 No. 1, Januari 2026
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34035/jk.v17i1.1749

Abstract

Background: To date, no research has explored the synergistic potential between saga leaves (Adenanthera pavonina L.) and sembukan leaves (Paederia foetida L.) in increasing the effectiveness of lowering cholesterol levels. This study aims to evaluate the potential of the combination of saga leaf ethanol extract and sembukan leaf in lowering cholesterol levels in hypercholesterolemia mice.Methods: The study used 36 mice divided into six treatment groups, including a negative control group, a positive control, a drug control, and a treatment group with different doses of a combination of ethanol extract of Saga leaves and Sembukan leaves. The spectrophotometer measured lipid levels on days 0, 21, and 24. Data analysis was done using the one-way ANOVA test to determine group differences.Results: The analysis showed that the combination of ethanol extract of saga leaves and sembukan leaves significantly reduced the cholesterol levels of hypercholesterolemia mice (p=0.000). The best dose for cholesterol reduction is 56 mg/20 g body weight (BW) with a 66% reduction.Conclusion: Combining ethanol extract of saga leaves and sembukan leaves at a dose of 56 mg/20 g body weight (BW) effectively reduced cholesterol levels in hypercholesterolemia mice. This research may contribute to developing alternative natural therapies to lower cholesterol levels and prevent cardiovascular disease.
Effectiveness of Ethanol Extract Dosage of Arabian Bidara Leaf (Zizphus spina-christi (L.) Desf.) on Reduction of Hypercholesterolemia in Mus musculus Valenata, Valenata; Patricia, Gaby Ayu; Ngibad, Khoirul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1449

Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular disease, which is characterized by increased cholesterol levels in the blood. The leaves of Ziziphus spina-christi (Arabian bidara) are known to contain flavonoids, saponins, tannins, and alkaloids that have the potential to provide antihypercholesterolemia effects. This study aimed to evaluate the effectiveness of ethanol extract of Z. spina-christi leaves on the reduction of total cholesterol in hypercholesterolemia mice. Extraction is carried out by the maceration method using 96% ethanol and produces a yield of 3.8%. A total of 36 male mice were divided into six groups (n=6): negative control, positive control (propylthiouracil induction), drug control (simvastatin), and three extract treatment groups with doses of 14, 28, and 56 mg/20 g BB. The treatment was given orally for four days, then cholesterol levels were analyzed using the enzymatic method CHOD-PAP. The results showed that the positive control cholesterol levels increased significantly (189.3 ± 6.2 mg/dL) compared to the negative control (112.7 ± 10.3 mg/dL). The administration of the extract lowered cholesterol levels gradually: 170.4 ± 6.3 mg/dL (10%), 159.6 ± 7.6 mg/dL (15.7%), and 147.3 ± 11.7 mg/dL (22.2%). Simvastatin decreased more (117.7 ± 12.5 mg/dL; 37.8%). It was concluded that bidara arabic leaf extract has antihypercholesterolemia potential with a multifactorial mechanism, although its effectiveness is lower than that of simvastatin.
Co-Authors Fadila, Ulfatul Ngibad, Khoirul Oktaviani, Galuh Anggun Rifqiyah, Jazilatur Valenata, Valenata Wijayanti, Cicik Yusmiati, Siti Nur Husnul