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All Journal Majalah Kedokteran Andalas Scientific Journal Eduvest - Journal of Universal Studies
Febrianti Ika Kurnia
Universitas Andalas, Padang
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Correlation of Serum Fibroblast Growth Factor 23 With Left Ventricular Diastolic Function in Chronic Kidney Patients Harun Harnavi; Febrianti Ika Kurnia; Kam Alexander
Eduvest - Journal of Universal Studies Vol. 2 No. 9 (2022): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1955.813 KB) | DOI: 10.59188/eduvest.v2i9.601

Abstract

Chronic Kidney Disease (CKD) is one of most common world’s health problems with constantly increasing prevalence and many complications, and cardiovascular is one of them. The earliest cardiovascular damage that can be seen is left ventricular diastolic dysfunction. In patients with CKD, there will be mineral metabolism disorders, including phosphate. Persistently increased phosphate in CKD will cause rising in Fibroblast Growth Factor 23 (FGF23) that regulates phosphate in the circulation. High level of FGF23 will directly damage the heart and stimulates cardiac remodeling that will result in cardiomyocyte damage, atherosclerosis and intramyocardial cells fibrosis. This will cause myocardial stiffness and diastolic dysfunction. The purpose of the study is to discover correlation between Fibroblast Growth Factor 23 (FGF23) serum and left ventricle diastolic function in patients with chronic kidney disease. This is an observational study with cross-sectional methods. The sample is 30 patients diagnosed with chronic kidney disease (CKD). Patients are evaluated for Fibroblast Growth Factor 23 (FGF23) level in their serum, assessed the left ventricle diastolic function by measuring early diastolic velocity of the left ventricle (lateral e’) using echocardiography.There is significantly increased of FGF23 serum levels and decreased of lateral e’ value in chronic kidney disease case. There’s also a strong correlation between FGF23 serum and filtration glomerulus rate (LFG) (p<0.05), and a strong correlation between FGF23 serum level with lateral e’ as a component of left ventricle diastolic function. There’s a strong correlation between FGF23 with left ventricle diastolic function in patients with CKD.
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Febrianti, Ika Kurnia; Putra, Andani Eka; Raveinal, Raveinal; Elliyanti, Aisyah
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p139-147.2024

Abstract

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects  (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death
Korelasi Kadar Gula Darah Puasa dengan HbA1c pada Pasien Diabetes Melitus Tipe 2 di RSUD Lubuk Basung Febrianti, Ika Kurnia; Ekawati, Desi
Scientific Journal Vol. 5 No. 1 (2026): SCIENA Volume V No 1, January 2026
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v5i1.299

Abstract

Pendahuluan: Diabetes melitus (DM) merupakan suatu penyakit dengan komplikasi yang memyebabkan masalah serius di bidang kesehatan secara global. Ketidaksesuaian antara kadar gula darah puasa (GDP) dan HbA1c sebagai standar pemeriksaan diabetes melitus tipe 2 (DMT2) dapat menyebabkan interpretasi klinis yang berbeda. Tujuan penelitian: Untuk mengetahui korelasi antara kadar GDP dengan kadar HbA1c pada pasien DMT2 di RSUD Lubuk Basung. Metode: Penelitian observasional dengan cross sectional study. Penelitian dilakukan bulan Januari-November 2025. Sampel digunakan sebanyak 120 data pasien DMT2 secara consecutive sampling yang ada di laboratorium patologi klinik RSUD Lubuk Basung, Kabupaten Agam, Sumatera Barat. Data kategorik ditampilkan dalam bentuk frekuensi dan persentase, data numerik ditampilkan dalam bentuk rerata dan standar deviasi. Dilakukan analisis korelasi antara kadar GDP dengan kadar HbA1c pada pasien DMT2, dinyatakan dalam koefisien korelasi Pearson bila data terdistribusi normal, atau uji korelasi Spearman bila tidak terdistribusi normal. Data diolah dengan SPSS 21.0, dihitung nilai kemaknaannya, bermakna jika p < 0,05. Hasil: Hasil penelitian didapatkan umur rata-rata pasien 59,61±12,53 tahun (termuda 24 tahun, tertua 96 tahun. Kadar GDP rata-rata 191,500 ± 92,218 mg/dl, (minimum 76,00 mg/dl, maksimum 504,00mg/dl). Kadar GDP normal 36 orang (30%), kadar GDP tinggi 84 orang (70%). Kadar HbA1c rata-rata 8,904±3,178 %, ( minimum 4,00%, maksimum 15,00%). Nilai HbA1c normal 5 orang (4,167%), dan HbA1c tinggi 115 orang (95,833%). Terdapat korelasi positif kuat antara GDP dan HbA1c pada pasien DMT2 (r=0,8678, dan p<0,05). Kesimpulan: Terdapat korelasi positif yang kuat antara kadar GDP dan HbA1c pada pasien DMT2. Kadar GDP yang tinggi cenderung diikuti HbA1c yang tinggi, sehingga GDP dapat digunakan sebagai indikator awal kontrol glikemik, dan HbA1c tetap menjadi pemeriksaan standar untuk evaluasi jangka panjang.
Co-Authors Aisyah Elliyanti Andani Eka Putra Desi Ekawati Harun Harnavi Kam Alexander RAVEINAL RAVEINAL