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All Journal Buletin Veteriner Udayana
I Wayan Gorda
Laboratorium Ilmu Bedah Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234
Immunology & microbiology Public Health Veterinary

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MACROSCOPIC ANALYSIS OF INCISION WOUND HEALING IN WHITE RATS TREATED WITH PLATELET-RICH PLASMA DERIVED FROM PORCINE BLOOD Made Sandy Widhi Raharja; I Wayan Wirata; Anak Agung Sagung Kendran; I Gusti Ngurah Sudisma; I Wayan Gorda; I Ketut Berata
Buletin Veteriner Udayana Bul. Vet. Udayana. April 2025 Vol. 17 No. 2
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i02.p10

Abstract

Platelet-rich plasma (PRP) has been identified as a potential therapeutic agent to mitigate factors that impede healing. PRP, which is enriched with growth factors, plays a critical role in accelerating tissue regeneration across various stages of wound repair. This study aimed to investigate the effects of PRP derived from porcine blood on the healing of incisional wounds in white rats (Rattus norvegicus). Macroscopic parameters, including wound length, wound color, moisture levels, and crust formation, were evaluated. The study employed an experimental design, utilizing a split-time completely randomized design (CRD) with statistical analysis. The results demonstrated significant improvements in wound closure, as evidenced by reduced wound length, accelerated changes in wound color, maintained wound moisture leading to faster drying, and enhanced crust formation, all of which contributed to a reduction in wound size (P < 0.05). These findings indicate that PRP derived from porcine blood significantly accelerates the healing process of incisional wounds in white rats, as reflected by macroscopic healing indicators. Further research is recommended to determine the optimal shelf life of PRP to ensure its efficacy and stability during prolonged storage, thereby supporting its sustainable clinical application.
ACUTE DERMAL IRRITATION TEST OF SIMPLISIA BUNGA GUMITIR OINTMENT ON ALBINO RABBIT Wayan Sangi Vani; I Made Merdana; I Wayan Gorda
Buletin Veteriner Udayana Bul. Vet. Udayana. June 2025 Vol. 17 No. 3
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i03.p33

Abstract

Marigold (Tagetes erecta L.) are widely cultivated for ornamental purposes and also as a natural food coloring. Gumitir flowers contain antioxidants, secondary metabolites such as terpenoids, essential oils, flavonoids, and carotenoids. This study aims to determine the results of the acute dermal irritation test of the simplicia flower gumitir ointment on albino rabbits, referring to The OECD Guideline for Testing of Chemicals - No. Test: 404, Acute Dermal Irritation/Corrosion (OECD) 2015. The test animals, consisting of three albino rabbits (Oryctolagus cuniculus), were treated with the simplicia flower gumitir ointment, with a placebo (negative control) as a comparison, using the patch test technique and evaluation based on the Amanded Draize test. The research results show that the application of gumitir flower simplicia ointment does not cause erythema and edema, both in the treatment and control groups, with a Mean Irritation Index of 0.16. Observation of reversibility effects showed the growth of fine and normal hair around the test area. It can be concluded that the gumitir flower simplicia ointment is non-irritating and therefore safe to use. It is recommended to conduct further tests as an effort to improve the salve made from gumitir flower simplicia, including salve formulation, stability testing, safety testing, and a review of previous test data.
Co-Authors Anak Agung Sagung Kendran I Gusti Ngurah Sudisma I Ketut Berata I Made Merdana I Wayan Wirata Made Sandy Widhi Raharja Wayan Sangi Vani