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All Journal Buletin Veteriner Udayana
Tri Komala Sari
Laboratorium Virologi Veteriner, Fakultas Kedokteran Hewan, Universitas Udayana, Jl. PB. Sudirman, Denpasar, Bali, 80234, Indonesia
Immunology & microbiology Public Health Veterinary

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MULTIORGAN LESIONS IN PIGLETS COINFECTED WITH STREPTOCOCCUS SUIS AND ASCARIS SUUM: A CASE STUDY Delima Marsinta Ida Pasaribu; I Nengah Kerta Besung; Ida Bagus Made Oka; I Made Kardena; Tri Komala Sari
Buletin Veteriner Udayana Bul. Vet. Udayana. October 2025 Vol. 17 No. 5
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i05.p12

Abstract

Pigs are among the most commonly raised livestock animals for human consumption. However, pig farming often faces significant challenges, particularly related to animal health. This case study aims to describe the anatomical pathology, histopathology, and laboratory findings to establish a definitive diagnosis of the disease that led to the death of a three-week-old piglet from Marga Village, Marga District, Tabanan Regency. Data collection included clinical observations, anamnesis, epidemiological data, and laboratory analyses, which were examined descriptively and qualitatively. The clinical signs observed in the piglet included anorexia, diarrhea, inability to stand, paddling, swelling of the limb joints, body tremors, and reddish skin lesions. Epidemiological data indicated a morbidity rate of 0.9%, a mortality rate of 0.9%, and a case fatality rate of 100%. Gross pathological findings revealed congestion and hemorrhages in the brain, lungs, heart, intestines, and kidneys. The liver and spleen appeared swollen and discolored, as did the stomach. Histopathological examination showed meningoencephalitis; hemorrhagic and edematous bronchopneumonia; intermyocardial edema; splenitis; hepatitis; hemorrhagic glomerulonephritis; gastritis; enteritis; and colitis. The dominant inflammatory cells were lymphocytes and macrophages, indicating a chronic infection. Bacteriological analysis revealed the presence of Streptococcus spp. in the brain, lungs, and liver, while parasitological examination identified Ascaris suum eggs. Based on the findings, the piglet was diagnosed with streptococcosis and ascariasis. Implementing strict biosecurity and sanitation measures is crucial in pig farming to prevent infectious diseases.
THE IMMUNOMODULATORY EFFECT OF PHYLLANTHUS NIRURI L. EXTRACT ON ANTIBODY TITERS IN NEWCASTLE DISEASE-VACCINATED BROILERS Daniel Halim; Ida Bagus Kade Suardana; Tjokorda Sari Nindhia; Tri Komala Sari; Ni Luh Eka Setiasih; Anak Agung Sagung Kendran
Buletin Veteriner Udayana Bul. Vet. Udayana. December 2025 Vol. 17 No. 6
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i06.p06

Abstract

Newcastle Disease (ND) remains a major threat to the poultry industry, and while vaccination is essential, the immune response can be inconsistent. This study evaluated the potential of Phyllanthus niruri L. (meniran) extract as an immunomodulator to enhance the humoral immune response in broilers post-ND vaccination. A total of 30 one-day-old broilers, vaccinated against ND, were divided into three treatment groups: P0 (control, no extract), P1 (extract at 5 mg/kg BW/day via drinking water from day 3 to 17), and P2 (extract from day 3 to 24). Antibody titers were measured using the Hemagglutination Inhibition (HI) test and analysed with ANOVA using SPSS software. The results demonstrated that meniran extract significantly increased antibody titters compared to the control (P<0.05). Group P2, which received the extract until day 24, achieved the highest mean titter (6.1 log2 HI units), followed by P1 (4.4 log2) and the control P0 (4.0 log2). Data analysis confirmed a positive relationship between the duration of extract administration and antibody levels. In conclusion, Phyllanthus niruri L. extract is an effective immunomodulator that significantly enhances the ND vaccine-induced antibody response in broilers, with a longer administration period yielding a more robust effect.
Co-Authors Anak Agung Sagung Kendran Daniel Halim Delima Marsinta Ida Pasaribu I Made Kardena I Nengah Kerta Besung Ida Bagus Kade Suardana Ida Bagus Made Oka Ni Luh Eka Setiasih Tjokorda Sari Nindhia