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All Journal ODONTO Dental Journal Odonto dental journal
Asriningrum, Vika
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Health Professions Medicine & Pharmacology

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Datura metel SEED NANO CHITOSAN EXTRACT GEL’S EFFECT ON ANGIOGENESIS WOUND HEALING OF WISTAR RAT Asriningrum, Vika; Bramanti, Indra; Ardhani, Retno
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.269-279

Abstract

Background: Datura metel possesses anti-inflammatory properties useful for treating oral mucosal injuries common in children, where healing relies on angiogenesis. Nano chitosan technology addresses herbal bioavailability issues. This study investigated the effect of 1% Datura metel seed nano chitosan extract gel on angiogenesis in Wistar rats. Methods: Eighteen Wistar rats were divided into three groups: 1% Datura metel seed chitosan extract, 1% nano chitosan extract, and a control group. Gels were applied to mandibular gingival wounds with assessments on days 3 and 5. Histological angiogenesis counts were analyzed using two-way ANOVA (p<0.05). Results: Significant differences in angiogenesis counts were found among the chitosan extract, nano chitosan extract, and positive control groups. Furthermore, variations in angiogenesis counts were observed between day 3 and day 5 across all groups. Conclusion: The 1% Datura metel seed chitosan extract gel demonstrated a greater effect in triggering angiogenesis compared to the 1% nano chitosan extract and the positive control.
Datura metel SEED NANO CHITOSAN EXTRACT GEL’S EFFECT ON ANGIOGENESIS WOUND HEALING OF WISTAR RAT Asriningrum, Vika; Bramanti, Indra; Ardhani, Retno
Odonto : Dental Journal Vol 12, No 3 (2025): December 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.3.269-279

Abstract

Background: Datura metel possesses anti-inflammatory properties useful for treating oral mucosal injuries common in children, where healing relies on angiogenesis. Nano chitosan technology addresses herbal bioavailability issues. This study investigated the effect of 1% Datura metel seed nano chitosan extract gel on angiogenesis in Wistar rats. Methods: Eighteen Wistar rats were divided into three groups: 1% Datura metel seed chitosan extract, 1% nano chitosan extract, and a control group. Gels were applied to mandibular gingival wounds with assessments on days 3 and 5. Histological angiogenesis counts were analyzed using two-way ANOVA (p<0.05). Results: Significant differences in angiogenesis counts were found among the chitosan extract, nano chitosan extract, and positive control groups. Furthermore, variations in angiogenesis counts were observed between day 3 and day 5 across all groups. Conclusion: The 1% Datura metel seed chitosan extract gel demonstrated a greater effect in triggering angiogenesis compared to the 1% nano chitosan extract and the positive control.
Co-Authors Indra Bramanti Retno Ardhani