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A Rare Case of Lower Limb Poroid Hidradenoma Anggreana, Farisa; Shelly, Wan Gifanni Efmadian; Fitriani, Katia; Andayani, Raden Roro Rini; Wirohadidjojo, Yohanes Widodo
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1354

Abstract

Introduction: Poroid hidradenoma (PH) is a benign tumor of the eccrine gland, which is the rarest variant of poroid tumor. The case reports that have been published since 1990 are around 75 cases. The presentation of PH lesions is nonspecific and varied, which often leads to misdiagnosis and requires histopathological examination to confirm the diagnosis. Case Presentation: A 53-year-old woman came with complaints of a prominent wound on her right lower leg for 4 years. Physical examination showed a partially bluish erythematous nodule accompanied by blackish brown crusted erosion in the central area, 1 cm in diameter, and solitary. Dermoscopic examination shows a central blue-grey pigmented area, a whitish halo, and erosion. The differential diagnosis of this case is keratoacanthoma, eccrine poroma, dermal duct tumor, and PH. Histopathological findings showed solid and cystic components, as well as poroid and cuticular cells in the dermis area. The final diagnosis in this case is PH.Conclusion: This report shows the challenge of PH diagnosis that requires an in-depth understanding of the clinical manifestation, dermoscopic, and histopathologic features.
Secondary syphilis psoriasiform in HIV-infected patients: A case series Fitriani, Katia; Alessandro Alfieri; Nurwestu Rusetiyanti; Devi Artami Susetiati; Niken Trisnowati; Satiti Retno Pudjiati
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.26999

Abstract

Psoriasiform secondary syphilis is an uncommon and diagnostically challenging variant of secondary syphilis that can closely mimic psoriasis vulgaris, particularly in people with HIV. This case series adds to the limited literature from resource-limited settings by illustrating how psoriasiform secondary syphilis may be misinterpreted as psoriasis both clinically and histopathologically, and how repeated clinicopathologic correlation is essential to avoid inappropriate immunosuppression. We reported three HIV-infected male patients who presented with generalized psoriasiform erythematous scaly plaques, some with palmoplantar involvement, initially diagnosed as psoriasis. One patient had been treated with methotrexate for severalmonths without clinical improvement. Serologic testing in all cases demonstrated active syphilis with reactive nontreponemal and treponemal tests, including a very high venereal disease research laboratory (VDRL) titer in one patient, and all were confirmed HIV-positive. Initial histopathologic examinations variably suggestedsecondary syphilis or psoriasis; in two patients, repeat biopsy or deeper sectioning was required to reveal plasma cell–rich perivascular infiltrates and vascular changes consistent with secondary syphilis, while one case was ultimately considered to represent coexistence of psoriasis and syphilis. All patients received intramuscularbenzathine penicillin G according to syphilis stage, with additional topical or systemic antiinflammatory therapy when indicated, and showed clinical improvement. In conclusion, psoriasiform secondary syphilis should be routinely considered in the differential diagnosis of psoriasiform eruptions in individuals with sexuallytransmitted infection risk or known HIV infection, and that discrepant clinical, serologic, and histopathologic findings warrant repeat biopsy, deeper sectioning, and multidisciplinary review.