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All Journal Journal of Pharmaceutical and Sciences. Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat
Musyarrofah, Laila
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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REVIEW: POTENSI DAN ASPEK KEAMANAN BAHAN ALAM LOKAL INDONESIA SEBAGAI ANTI ACNE Fitriani, Hani Sri; Pratama, Arvenda Rezky; Musyarrofah, Laila; Mirta, Surya Bin
Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Vol. 4 No. 2 (2025): JURNAL INOVASI BAHAN LOKAL DAN PEMBERDAYAAN MASYARAKAT (IN PRESS)
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jibpm.v4i2.4369

Abstract

Acne vulgaris is a complex skin disorder influenced by the colonization of Cutibacterium acnes, increased sebum production, follicular hyperkeratinization, and inflammatory responses. Limitations of conventional therapies, including skin irritation and the emergence of antibiotic resistance, have encouraged the exploration of natural ingredients as alternative anti-acne agents. Indonesia possesses exceptionally high biodiversity, offering significant potential for the development of locally sourced natural anti-acne products. This review discusses the potential and safety aspects of Indonesian local natural ingredients as anti-acne agents based on credible national and international scientific literature. Natural materials such as turmeric (Curcuma longa), Javanese turmeric (Curcuma xanthorrhiza), betel leaf (Piper betle), aloe vera (Aloe vera), gotu kola (Centella asiatica), and green tea (Camellia sinensis) are examined in terms of their biological activities and safety profiles. Emphasis is placed on the importance of raw material standardization, dose control, and evidence-based safety evaluation to support the safe, rational, and competitive utilization of Indonesian local natural ingredients as anti-acne agents. Keywords: acne vulgaris; anti-acne; Cutibacterium acnes; Indonesian local natural ingredients; safety
Analisis Kandungan Merkuri dan Hidrokuinon dalam Krim Pemutih Wajah Daring Menggunakan Spektrofotometer Serapan Atom dan Kromatografi Cair Kinerja Tinggi Kusmiyati, Mimin; Tronovani , Elvi; Sulaeman , Agus; Musyarrofah, Laila; Fitriani , Hani Sri; Khotimah , Enung Nur; Mirta, Surya Bin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1176

Abstract

The skin is the outermost organ of the human body and plays an important protective and physiological role. Currently, fair skin is often regarded as a beauty standard desired by both men and women. Mercury and hydroquinone are active ingredients commonly used in whitening products due to their ability to inhibit melanin formation; however, their use can cause serious toxic effects. This study aimed to determine the presence of mercury and hydroquinone qualitatively and quantitatively in facial whitening creams sold online in Bandung City. Samples showing positive results were further analyzed quantitatively to determine their concentrations. For mercury analysis, samples were digested using a microwave digestion method to eliminate organic substances. The color reaction test for mercury employed KI 0.5 N, HCl 6 M, and NaOH 2 N reagents. Based on qualitative testing, samples labeled D and N were positive for mercury. Quantitative determination of mercury was conducted using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 253.7 nm. For hydroquinone analysis, qualitative color tests were carried out using FeCl₃ 5%, phenanthroline, and Benedict reagents, while quantitative analysis was performed using High-Performance Liquid Chromatography (HPLC). Of the 17 samples tested, two (D and N) contained mercury at concentrations of 2,776 ±  0,036 μg/g and 4,277 ± 0,021 μg/g, respectively, and two others (E and H) contained hydroquinone 2,3745% and 2,4798%.
Co-Authors ARVENDA REZKY PRATAMA, ARVENDA REZKY Fitriani , Hani Sri Fitriani, Hani Sri Khotimah , Enung Nur Mimin Kusmiyati, Mimin Mirta, Surya Bin Sulaeman , Agus Tronovani , Elvi