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All Journal Jurnal Kesehatan Gigi The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry
Tifani, Amara Syifa
Master Program In Biomedical Science, Faculty Of Medicine, Universitas Brawijaya, Jl. Veteran, Malang 65145
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Mobile-Based Oral Health Self-Screening and Education Application for Pregnant Women Riolina, Ana; Yulian, Vinami; Sukin, Sukin; Alma Raudhia, Syafira; Syifa Tifani, Amara; Aqila Majid, Alya; Nada Putri, Dhiya; Aisyah, Miranda
Jurnal Kesehatan Gigi Vol. 12 No. 2 (2025): December 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.13014

Abstract

Low utilization of dental services among pregnant women, ranging from 35.5% to 49%, is often caused by barriers such as cost, limited awareness, myths about oral health during pregnancy, and fears regarding dental treatment’s impact on the fetus. Local data from the prenatal class and dental clinic at Puskesmas Baki, Gedongan, Sukoharjo, indicate similarly low rates of dental check-ups. This study aimed to develop and evaluate the ‘Ibu Peri Cerita’ mobile application as a tool for self-screening and improving oral health knowledge during pregnancy. A pre-post test design was used with an experimental sample of 23 pregnant women, who were first asked to answer ten oral health knowledge questions.. Participants then used the application to perform a self-assessment and receive educational content, followed by a post-test. The results showed a notable increase in knowledge scores, with the average pre-test score at 4.61 improving to 6.48 post-intervention. Minimum scores increased from 1 to 4, and maximum scores from 8 to 9. These findings suggest that the ‘Ibu Peri Cerita’ application is effective in increasing oral health literacy among pregnant women. The improvement in awareness is expected to support better prenatal health outcomes and contribute to reducing the risk of low birth weight and stunting.
Chitosan–Aloe vera Combination Enhances STRO-1, DSPP, and Reparative Dentin Formation in a Rat Model of Reversible Pulpitis Amara Syifa Tifani; Ranny Rachmawati; Yuli Nugraeni; Adam Fauzi; Rachmi Fauziah Rahayu
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3851

Abstract

BACKGROUND: Direct pulp capping (DPC) aims to preserve pulp vitality but requires agents that are both bioactive and biocompatible. Calcium hydroxide (CaOH2) is widely used, however its long-term success is limited, and it may cause adverse effects. Natural biomaterials such as chitosan and Aloe vera have shown potential, but their combined regenerative effects are still not well understood. This study was conducted to evaluate the efficacy of chitosan–Aloe vera composites in promoting stem cell activation, odontoblast differentiation, and reparative dentinogenesis in a rat model of reversible pulpitis.METHODS: Twenty-four Wistar rats with mechanically induced reversible pulpitis were divided into six groups: normal control, reversible pulpitis, CaOH2, and chitosan–Aloe vera pastes at 20%, 30%, and 40% (CA20, CA30, CA40). Pulp capping was performed following standardized pulp exposure. After 28 days, reparative dentin thickness and dentin bridge formation were assessed histologically, and STRO-1 and dentine sialophosphoprotein (DSPP) expression were analyzed immunohistochemically.RESULTS: Dentin bridge was observed in the CA40 group, presenting the thickest dentin formation (113.5±13.5 μm). STRO-1 and DSPP were significantly higher in all chitosan–Aloe vera combination groups compared with reversible pulpitis group (p<0.01), with DSPP in CA30 and CA40 also higher than CaOH2 group. Both biomarkers demonstrated a positive correlation, and reparative dentin thickness showed a strong positive correlation with DSPP level (r=0.786, p<0.001).CONCLUSION: Chitosan–Aloe vera combination showed encouraging biological activity in this 28-day preclinical model of reversible pulpitis. Although higher concentrations enhanced stem cell activation, odontoblast differentiation, and reparative dentin formation, these results should be interpreted cautiously due to the small sample size and study design limitations.KEYWORDS: pulp capping, STRO-1, DSPP, dentin bridge, CaOH2, natural biomaterial, endodontics
Combined Vitamin D and Magnesium Supplementation Improves Insulin, HOMA Indices, Blood Glucose, and Oxidative Stress Markers in Diabetic Rats Azzahra, Balqis Faizah; Yueniwati, Yuyun; Permatasari, Happy Kurnia; Rahayu, Rachmi Fauziah; Tifani, Amara Syifa; Fauzi, Adam
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3905

Abstract

BACKGROUND: Diabetes mellitus (DM) is characterized by disturbances in glucose homeostasis, chronic low-grade inflammation, and heightened oxidative stress. Alterations in vitamin D status and magnesium homeostasis are frequently observed in DM and have been implicated in impaired insulin secretion, decreased insulin sensitivity, and dysregulated antioxidant responses. Although both micronutrients have independently demonstrated potential benefits on glycaemic regulation and oxidative balance, the synergistic therapeutic effects of combined vitamin D and magnesium supplementation remain insufficiently elucidated in experimental models of type 2 DM. Therefore, this study was conducted to determine the effects of combined vitamin D and magnesium supplementation on insulin dynamics, glycaemic control, and oxidative stress markers in streptozotocin-induced diabetic rats.METHODS: Twenty-four male Wistar white rats were divided into 4 groups: normal control, diabetic control, metformin group, and vitamin D + magnesium group. DM was induced using streptozotocin–nicotinamide injection. Glycaemic parameters including insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and homeostatis model assessment of β-cell function (HOMA-β), were evaluated from fasting serum using immunoassay-based analyses; while oxidative stress markers including superoxide dismutase (SOD) and malondialdehyde (MDA) were measured from plasma using colorimetric spectrophotometric methods.RESULTS: Vitamin D and magnesium combination achieved the greatest reduction in blood glucose. The mean insulin level and HOMA-β index in the vitamin D + magnesium group were significantly higher than in both the diabetic control and metformin groups (p<0.001). In the same group, HOMA-IR and MDA levels were significantly lower, whereas SOD activity was significantly higher compared with diabetic group and metformin group (p<0.001).CONCLUSION: The combination of vitamin D and magnesium increases insulin and HOMA-β level and decreases HOMA-IR, SOD, and MDA expressions in diabetic Wistar rats.KEYWORDS: diabetes mellitus, magnesium, vitamin D, insulin resistance, inflammation
Analysis of failure rates among calcium hydroxide, biodentine, and mineral trioxide aggregate in direct pulp capping procedures: a systematic review Tifani, Amara Syifa; Nugraeni, Yuli; Rachmawati, Ranny; Huang, Haw-Ming; Fauzi, Adam
Padjadjaran Journal of Dentistry Vol 38, No 1 (2026): March 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no1.66578

Abstract

Introduction: Direct pulp capping is a conservative treatment approach aimed at preserving pulp vitality following pulp exposure. Calcium hydroxide (Ca(OH)₂), mineral trioxide aggregate (MTA), and Biodentine are commonly used materials for this procedure. This systematic review aimed to compare the clinical, radiographic, and histological outcomes associated with these materials in direct pulp capping procedures. Method: A systematic literature search was conducted in PubMed, Scopus, ScienceDirect, and Google Scholar for studies published between 2015 and 2025. Only in vivo human clinical studies involving permanent teeth treated with Ca(OH)₂, MTA, or Biodentine were included. Study selection followed PRISMA guidelines. Data extraction focused on clinical success, pulp vitality, dentin bridge formation, and follow-up outcomes. Due to heterogeneity among the included studies, results were synthesized narratively. Results: Six clinical studies met the inclusion criteria and were included in the qualitative synthesis. Reported success rates for Ca(OH)₂ ranged from 13% to 37% in long-term follow-up. MTA demonstrated success rates exceeding 80% in studies with follow-up durations of at least 12 months. Biodentine showed comparable or slightly higher success rates than MTA in short- to medium-term observations. Radiographic and histological outcomes indicated more continuous dentin bridge formation in the MTA and Biodentine groups compared to Ca(OH)₂. Conclusion: Based on the available evidence, calcium silicate–based materials such as MTA and Biodentine appear to provide more favorable clinical and biological outcomes than calcium hydroxide for direct pulp capping procedures. Material selection should consider both biological performance and clinical handling characteristics to optimize treatment outcomes.
Co-Authors Adam Fauzi Aisyah, Miranda Alma Raudhia, Syafira Ana Riolina Aqila Majid, Alya Azzahra, Balqis Faizah Happy Kurnia Permatasari Huang, Haw-Ming Nada Putri, Dhiya Rachmi Fauziah Rahayu Rachmi Fauziah Rahayu Ranny Rachmawati Ranny Rachmawati Sukin, Sukin Vinami Yulian Yuli Nugraeni Yuli Nugraeni, Yuli Yuyun Yueniwati