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All Journal Journal of Biomedicine and Translational Research Program Kreativitas Mahasiswa - Penelitian B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah E-Prodenta Journal of Dentistry Caring : Jurnal Pengabdian Masyarakat
Ranny Rachmawati
Pendidikan Dokter Gigi, Fakultas Kedokteran, Universitas Brawijaya Malang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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O’MARK: INOVASI PEMANFAATAN PROSTAGLANDIN E2 DALAM SALIVA SEBAGAI EVALUASI TINGKAT KEPARAHAN PERIODONTITIS Amelia, Fitri; Pustaka, Tiana; Irsyadi, Fahmi Tsani; Fitriana, Ardian Ayu; Seputraningrum, Yuliana; Rachmawati, Ranny
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.889 KB)

Abstract

Periodontitis is an inflammatory disease affects teeth supporting tissues which causing loss of periodontal attachment and damaging alveolar bone. Periodontitis trigger host to produce monocytes, polymorphonuclears (PMN), macrophages and others to release inflammatory mediators such as IL-1, TNF-α, PGE2. In periodontal disease, PGE2 role in breakdown of alveolar bone. The biomarker used PGE2 that contained in human saliva. This research aims to prove that PGE2 in saliva could be a new method to measure severity and early diagnosis of periodontitis. This research used Post Test Only Controlled Group Design with human saliva as the samples. The samples collected from 20 patients divided into two groups which are: control group (patient without periodontitis) and experimental group (patient with periodontitis). Saliva collecting method which used was Passive Drool with 2 ml for each. Afterwards, the samples isolated with a kit to make sure the PGE2 in saliva active and then the ELISA test did. Data analysis used Independent T Test with p<0,05 to know comparison the level of PGE2 in both groups. Thereafter, a ROC curve analysis with p<0,05 used to find out sensitivity and specifity of PGE2 in saliva towards periodontitis. The amount of PGE2 in saliva were significantly increased in periodontitis patients compared with healthy patients, also PGE2 in saliva specific enough and sensitive to periodontitis so its could be used as a valid diagnostic tool in measuring the severity of periodontitis. Keywords:  Prostaglandin E2, saliva, periodontitis, early diagnose, severity
Peran Perawat Dalam Meningkatkan Kebersihan Gigi Dan Mulut Anak Tunagrahita Palupi, Dyah Nawang; Rachmawati, Ranny; Anggraini, Zamidha Octarina
E-Prodenta Journal of Dentistry Vol 1, No 1 (2017)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.899 KB) | DOI: 10.21776/ub.eprodenta.2017.001.01.5

Abstract

  Latar belakang: Pengetahuan tentang kebersihan gigi dan mulut dan keterampilan menyikat gigi yang baik dan benar pada anak tuna grahita masih kurang sekalipun anak tunagrahita ringan memiliki tingkat kecerdasan lebih tinggi dari pada derajat retardasi yang lain. Anak tuna grahita membutuhkan perawat untuk membantu menjaga kebersihan gigi dan mulut. Perilaku adaptif diperlukan anak tuna grahita ringan untuk meningkatkan kesehatan gigi dan mulut.Tujuan: untuk mengetahui peran perawat anak tunagrahita dalam meningkatkan kesehatan gigi dan mulut anak tunagrahitaMetode: pra-eksperimental dengan rancangan penelitian One Group Pretest Posttest. Sampel penelitian adalah anak dengan IQ 69-55 menurut skala Weschler (WISC) (n=30) dan perawat tunagrahita (n=18). Check list digunakan pada perawat tunagrahita setelah dilakukan penyuluhan teknik menyikat untuk mengukur perubahan keterampilan menyikat gigi dan pengukuran OHI-s anak tuna grahita ringan.Hasil penelitian: terdapat penurunan OHI-s anak tunagrahita sebelum dan sesudah penyuluhan pada perawat tunagrahita.Kesimpulan: penyuluhan pada perawat tunagrahita efektif dalam meningkatkan kebersihan mulut anak tunagrahita ringan yang ditandai dengan turunnya nilai OHI-s anak tunagrahita ringan sesudah diberikan penyuluhan cara menyikat gigi oleh perawat.   Kata kunci: perawat, anak tunagrahita, OHI-s.
SCHOOL HEALTH PROGRAMME FOR STUDENTS, TEACHERS, AND PARENTS IN ELEMENTARY TO IMPROVE ORAL HEALTH KNOWLEDGE IN MALANG Feni Istikharoh; Trining Widodorini; Yuanita Lely Rahmawati; Sinta Candra Wardani; Ranny Rachmawati; Meilia Aquina Hakim; Citra Insany Irgananda
Caring : Jurnal Pengabdian Masyarakat Vol 3, No 1 (2023): CARING Jurnal Pengabdian Masyarakat (April 2023)
Publisher : Caring : Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2023.003.01.4

Abstract

Dental and oral health has an important role in supporting the health of the human body. Diseases and disorders of the teeth in school-age children between 7-15 years are disturbances in growth and development. However, many factors still influence the occurrence of dental and oral problems. One of them is the lack of attention and knowledge. At the age of children, parents and teachers have an important role in guiding, providing understanding, reminding and providing facilities to maintain healthy teeth and mouth. Therefore, all three of them need to know to underlie the formation of behaviors that support children adopting a healthy lifestyle. Based on these conditions, we conducted community service to increase this knowledge through the School Health Program, which was implemented in 7 elementary schools in Malang City. In this activity, education was carried out for students, parents and teachers with a total of 325 participants. The results of this program show an increase in knowledge by students, teachers and parents. The knowledge conveyed included basic dental care recommendations such as brushing teeth twice a day with fluoride toothpaste, managing good eating habits, staying away from bad habits that damage teeth and preventing dental caries as early as possible. After completing this activity, participants can adopt a healthy lifestyle to prevent problems with their teeth and mouth. 
THE EFFECTIVENESS OF PROCYANIDIN ON RED GRAPE SEED EXTRACT IN TREATMENT OF PERIODONTITIS INDUCED BY DIABETES MELLITUS Rachmawati, Ranny; Handoko, Monica Annasthasia; Avrilia, Isabella; Wisnawati, Angela Latisha
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 11, No 1 (2024): Vol 11 No 1, Juni 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v11i1.1604

Abstract

Introduction: Periodontal disease, including periodontitis, ranks as the 6th complication for Diabetes Mellitus. Research has found an increase of inflammation and higher alveolar bone loss in the periodontal of diabetes mellitus patients. One of the components which exhibited multiple bio-activities like anti oxidative, anti-inflammatory, antidiabetic antimicrobial cardioprotective, neuroprotective, immunomodulatory, and anti-obesity activities is procyanidin. Procyanidin can be found in various natural ingredients and one of the most abundant compositions is found in red grape seeds. Methods: The method used in this study is a literature review from several academic databases including : Google Scholar, PubMed, Mendeley, Wiley, and the university's online library with boolean searching method. Results: The several articles used in this literature review show that the protective effect of grape seed procyanidin plays a role in attenuating the increase of MFG-E8, suppressing the increase of IL-1beta protein level, improving HOMA-IR and insulin levels in diabetes, increasing IL-10 and TGF-beta accumulation in the gingival epithelium of periodontitis condition, and MMP- and HIF-1alpha immunohistochemistry showed an increase in its levels for periodontitis with diabetes rats, but decreased as grape seed procyanidin extract (GSPE) was administered. Conclusion: The present study suggested that procyanidin in grape seed extract played a role in treating periodontitis in diabetes patients through its anti- inflammatory role and its ability to decrease alveolar bone loss. There are still very few studies regarding this topic, therefore
Effect of Umbilical Cord Cell Isolate Administration on STRO-1 and CD 34 Expression of Dental Pulp Stem Cell Culture Nugraeni, Yuli; Rachmawati, Ranny; Az Zahra, Akyla Oktriza; Nugraha, Adelia Adzra
Journal of Biomedicine and Translational Research Vol 11, No 2 (2025): August 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i2.26269

Abstract

Background: Dental Pulp Stem Cell (DPSC) is one of the ideal mesenchymal stem cells (MSCs) for the repair of damaged cells, as it has great proliferative potential and the ability to regenerate pulp-like complex dentins. However, DPSC has limitations in providing stem cell sources due to its small number. Therefore, it is induced with umbilical cord cell isolate (hUC-MSC) which is currently widely developed because of its advantages that are easy to obtain, have proliferative potential, and have anti-inflammatory effects. However, its influence and effectiveness on Dental Pulp Stem Cells is not widely known.Objective: To prove the effect of umbilical cord cell isolate on the expression of Stro-1 and CD 34 in Dental Pulp Stem Cell (DPSC) culture.Methods: This study is experimental laboratory with simple random sampling which is divided into 4 groups, namely 2 control groups and 2 groups of umbilical cord isolate administration which are observed for 12 hours and 24 hours. Observation of expression by immunohistochemical staining was then calculated using Qupath software in 5 fields of view.Results: The treatment group that was given umbilical cord cell isolate showed the highest increase in Stro-1 and CD 34 expression at 24-hour observation compared to the untreated group.Conclusion: There was an increase in the expression of Stro-1 and CD 34 in Dental Pulp Stem Cell cultures after being given umbilical cord cell isolate.
Co-Authors Anggraini, Zamidha Octarina Ardian Ayu Fitriana, Ardian Ayu Avrilia, Isabella Az Zahra, Akyla Oktriza Citra Insany Irgananda Fahmi Tsani Irsyadi, Fahmi Tsani Feni Istikharoh Fitri Amelia Handoko, Monica Annasthasia Meilia Aquina Hakim Nugraha, Adelia Adzra Palupi, Dyah Nawang Sinta Candra Wardani Tiana Pustaka, Tiana Trining Widodorini Wisnawati, Angela Latisha Yuanita Lely Rahmawati Yuli Nugraeni, Yuli Yuliana Seputraningrum, Yuliana