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All Journal Indonesian Journal of Cancer The Indonesian Biomedical Journal Universa Medicina Majalah Kesehatan FKUB Smart Medical Journal Indonesian Journal of Medicine
Rachmi Fauziah Rahayu
Bagian Radiologi RSUD Dr. Moewardi
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit Widiastuti, Widiastuti; Rahayu, Rachmi Fauziah; Susianto, Djoko; Budianti, Rita; Priyanto, Heru; Moedigdo, Ambar; Soegiartiningsih, Soegiartiningsih
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.26 KB) | DOI: 10.33371/ijoc.v12i1.552

Abstract

Orbital metastases of cervical cancer cell are very rare. There is only one case reported in Dr. Moewardi Public Hospital Surakarta between 1999 and 2017. A 45-year-old woman was admitted with the upper right orbital lesion. She had not received a routine gynecologic examination for more than 10 years. She had normal chest X-ray. Abdominal ultrasonography revealed a heteroechoic lesion poor defined edge in cervix utery expands to corpus utery and rectum. Bilateral uropathy obstruction occured. Bone survey demonstrated osteolytic bone metastasis in the right supra orbital bone and a compression fracture of the twelfth thoracal spine. Head and orbital Computed Tomography (CT) scan, which revealed multiple metastatic lesions in the right orbital expanding to extra cranial, was performed. Our diagnosis was cervical cancer FIGO IV-B stage with distant metastasis thus chemoradiation was given. The aim of this report is to give more references regarding this complicated clinical condition.  ABSTRAKKanker serviks metastasis ke orbita sangat jarang terjadi. Hanya satu kasus yang dilaporkan di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta antara tahun 1999 - 2017. Seorang wanita usia 45 tahun dirawat oleh karena lesi di orbita kanan atas sejak 2 bulan yang lalu. Pasien tersebut belum pernah mendapatkan pemeriksaan kandungan rutin selama lebih dari 10 tahun. Foto Chest X Ray normal. Ultrasonografi abdomen tampak lesi heteroekoik batas tak tegas pada serviks uterus meluas ke korpus uterus dan rektum. Terjadi obstruksi uropati kanan dan kiri. Bone survei memperlihatkan gambaran metastasis tipe litik pada tulang supra orbita kanan dan fraktur kompresi pada tulang belakang toraks ke dua belas. Computed Tomography (CT) Kepala dan Orbita memperlihatkan beberapa lesi metastasis pada supra orbita kanan yang meluas ke tulang tengkorak. Diagnosis kami adalah kanker serviks tahap FIGO IV-B dengan metastasis jauh dan diberikan therapi kemoradiasi. Tujuan penulisan ini adalah untuk memberikan lebih banyak referensi data tentang kondisi klinis yang rumit ini.
The diagnostic value of apparent diffusion coefficient to differentiate benign and malignant meningiomas Marissa, Risa; Rahayu, Rachmi Fauziah; Wujoso, Hari; Subandi, Subandi; Putro, Prasetyo Sarwono; Soewondo, Widiastuti
Universa Medicina Vol. 40 No. 2 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.141-150

Abstract

BACKGROUNDMeningiomas are the most common primary extra-axial non-glial intracranial tumors. The severe grade of meningioma, according to WHO, has the highest recurrence rate accompanied by high morbidity and mortality rates. Therefore, it is imperative to perform pre-operative assessments so the clinician can give prompt treatment to gain a better prognosis. It is a novel alternative way of predicting meningioma’s malignancy by calculating the tumor’s apparent diffusion coefficient (ADC) value. The objective of the study was to determine the value of ADC for differentiating benign and malignant meningiomas. METHODSThis cross-sectional study involved 32 subjects with clinically diagnosed or histologically verified meningioma (21 benign and 11 malignant). They underwent a head-magnetic resonance imaging (MRI) examination and biopsy. We calculated the ADC value by creating regions of interest (ROIs) on the solid part of the tumor, guided by contrast and fluid-attenuated inversion recovery (FLAIR) sequence. We analyzed the ADC value with independent t-test and Bland-Altman graphs, calculated the average difference, CI 95%, limit of agreement between observers, and ROC. RESULTSMean ADC of malignant meningiomas (0.877 ± 0.167 x 10-3 mm2/s) was significantly lower than that of benign meningiomas (0.990 ± 0.105 x 10-3 mm2/s) (p<0.05). The ADC threshold is 0.886 x 10-3 mm2/s with sensitivity 63.6%, specificity 85.7%, positive predictive value 70% and negative predictive value 81.8%. CONCLUSIONThe ADC value measurement provides a discriminative feature to differentiate between benign and malignant meningiomas. However, the clinical applicability still needs to be elucidated, as histopathological confirmation remains the mainstay of definitive diagnosis.
RONTGEN TORAKS SEBAGAI PREDIKTOR HASIL TES REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION (RT-PCR) UNTUK DIAGNOSIS COVID-19 Rahayu, Rachmi Fauziah; Maharina, Luths; Prabata, Adam; Ropitasari, Ropitasari; Widiastuti, Widiastuti; Yueniwati, Yuyun
Majalah Kesehatan FKUB Vol 8, No 2 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.02.5

Abstract

COVID-19 merupakan penyakit infeksi yang telah menjangkiti banyak negara di seluruh dunia, termasuk Indonesia. Pemeriksaan RT-PCR merupakan metode standar penegakkan diagnosis COVID-19, namun kapasitas laboratorium di Indonesia belum mampu melakukan pemeriksaan tersebut dalam jumlah adekuat. Rontgen toraks merupakan salah satu modalitas radiologi, yang umum ditemukan dan harganya terjangkau, yang dapat digunakan untuk penapisan pasien suspek COVID-19 sebelum dilakukan pemeriksaan RT-PCR. Rontgen toraks dapat menjadi pilihan modalitas untuk membantu penegakan diagnosis COVID-19 lebih cepat, terutama di daerah dengan fasilitas pemeriksaan RT-PCR yang terbatas. RSUD Dr Moewardi sebagai salah satu pusat rujukan Posko Kesehatan Siaga COVID-19 di Jawa Tengah melakukan pemeriksaan rontgen toraks sebagai program penapisan dan evaluasi keadaan pasien yang terindikasi terpapar COVID-19. Sejak 4 Mei 2020 hingga 28 Juni 2020, pemeriksaan rontgen toraks sebagai pemeriksaan awal  yang dilakukan terhadap 109 subjek dengan lokasi di Instalasi Radiologi RSUD dr. Moewardi, pemeriksaan kemudian dilanjutkan dengan pemeriksaan RT-PCR.  Temuan abnormal pada rontgen toraks didapatkan pada 28 (25,7%) orang dengan adanya  infiltrat  mendominasi pada 17 (60,7%) orang, diikuti dengan gambaran  air bronchogram pada 7 (25%) orang, dan GGO pada 4 (14,3%). Temuan abnormal yang ditemukan pada pemeriksaan rontgen toraks pada orang-orang yang bergejala dapat digunakan sebagai prediktor hasil tes RT-PCR untuk diagnosis COVID-19.
Differences in Age Estimated by the Kvaal Method on Right and Left Mandibular Canines Kusumaningrum, Sulistyani; Wasita, Brian; Wujoso, Hari; Rahayu, Rachmi Fauziah; Hermansyah, Muhamad Lukman; Lawei, Tharina
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.495 KB) | DOI: 10.26911/theijmed.2021.6.2.401

Abstract

Background: The radiographic method for deter­mining the estimated age has the advantage of being non-invasive and the orthopantomogram images are digitally processed. Canines have a strong corre­la­tion with chronological age and have good resistance and large pulp space. This study aimed to determine the difference in age estimates using the Kvaal method on the right and left mandibular canines.Subjects and Method: There were 80 ortho­pantomogram samples from dental and oral clinic patients who had undergone orthopantomography at the Radiology Installation of Dr. Moewardi Hos­pital, from January 2019 to December 2020. The estimated age of right and left canines was calcu­lated based on the Kvaal method and performed a T-test.Results: At the estimated age of the right and left mandibular canines determined by the Kvaal formula, the T-test was performed showing a mean of 38.3 years for the right mandibular canine (Mean= 38.3; SD= 6.7) and 38.2 year the left mandi­bular canine (Mean= 38.2; SD= 8.9), with p = 0.910. Data analysis showed that there was no difference in age estimation using the Kvaal method on the right and left mandibular canines.Conclusion: There was no difference in age estimates by the Kvaal method on the right and left mandibular canines.Keywords: Oratopantomogram, Metoday Qual, Kaninus MandibulaCorrespondence: Sulistyani Kusumaningrum. Department of Radiology Dr. Moewardi Hospital / Faculty of Medicine Universitas Sebelas Maret, Surakarta. Email: kusumasulis1@gmail.com.Indonesian Journal of Medicine (2021), 06(02): 206-211https://doi.org/10.26911/theijmed.2021.06.02.09
Combined Vitamin D and Magnesium Supplementation Improves Insulin, HOMA Indices, Blood Glucose, and Oxidative Stress Markers in Diabetic Rats Azzahra, Balqis Faizah; Yueniwati, Yuyun; Permatasari, Happy Kurnia; Rahayu, Rachmi Fauziah; Tifani, Amara Syifa; Fauzi, Adam
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3905

Abstract

BACKGROUND: Diabetes mellitus (DM) is characterized by disturbances in glucose homeostasis, chronic low-grade inflammation, and heightened oxidative stress. Alterations in vitamin D status and magnesium homeostasis are frequently observed in DM and have been implicated in impaired insulin secretion, decreased insulin sensitivity, and dysregulated antioxidant responses. Although both micronutrients have independently demonstrated potential benefits on glycaemic regulation and oxidative balance, the synergistic therapeutic effects of combined vitamin D and magnesium supplementation remain insufficiently elucidated in experimental models of type 2 DM. Therefore, this study was conducted to determine the effects of combined vitamin D and magnesium supplementation on insulin dynamics, glycaemic control, and oxidative stress markers in streptozotocin-induced diabetic rats.METHODS: Twenty-four male Wistar white rats were divided into 4 groups: normal control, diabetic control, metformin group, and vitamin D + magnesium group. DM was induced using streptozotocin–nicotinamide injection. Glycaemic parameters including insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and homeostatis model assessment of β-cell function (HOMA-β), were evaluated from fasting serum using immunoassay-based analyses; while oxidative stress markers including superoxide dismutase (SOD) and malondialdehyde (MDA) were measured from plasma using colorimetric spectrophotometric methods.RESULTS: Vitamin D and magnesium combination achieved the greatest reduction in blood glucose. The mean insulin level and HOMA-β index in the vitamin D + magnesium group were significantly higher than in both the diabetic control and metformin groups (p<0.001). In the same group, HOMA-IR and MDA levels were significantly lower, whereas SOD activity was significantly higher compared with diabetic group and metformin group (p<0.001).CONCLUSION: The combination of vitamin D and magnesium increases insulin and HOMA-β level and decreases HOMA-IR, SOD, and MDA expressions in diabetic Wistar rats.KEYWORDS: diabetes mellitus, magnesium, vitamin D, insulin resistance, inflammation
Vitamin D and Magnesium Combination Lowers High-Sensitivity C-Reactive Protein, Interleukin-12, Renin, and Carotid Vessel in Diabetic Rats Rahayu, Rachmi Fauziah; Zahrah, Fathimah Afifah; Anugrah, Tessa Septian; Yudhani, Ratih Dewi; Yueniwati, Yuyun; Irawan, Amelia Tjandra; Kusumaningrum, Sulistyani; Fauzi, Adam; Wasita, Brian; Wiyono, Nanang; Muthaminah, Muthaminah; Sholikah, Tri Agusti; Wardhani, Lusi Oka; Suyatmi, Suyatmi; Yarso, Kristanto Yuli; Pesik, Riza Novierta; Siswanto, Febby Gunawan
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4061

Abstract

BACKGROUND: Diabetes mellitus induces oxidative stress, inflammation, and endothelial dysfunction, accelerating atherosclerosis development marked by elevated high-sensitivity C-reactive protein (hs-CRP) and interleukin-12 (IL-12). Diabetes often causes significant vascular changes, which can be represented by carotid tunica intima thickening and elevated renin level. Metformin, which remains as the standard therapy, has limited vascular effects. Vitamin D and magnesium exhibit vasoprotective and anti-inflammatory properties; however, their combined effects on diabetic vascular injury remain unclear. This study evaluated the effects of vitamin D and magnesium combination on serum hs-CRP, IL-12, renin, and carotid tunica intima thickness in diabetic rats.METHODS: Wistar rats were diabetic-induced by 45 mg/kg streptozotocin and 110 mg/kg nicotinamide. Following the induction, the rats were subsequently assigned to receive no treatment, metformin, or a combination of vitamin D and magnesium. Healthy rats were also included as control. Blood sample was collected after 21 days of treatment. Serum hs-CRP, IL-12, and renin were measured using enzyme-linked immunosorbent assay (ELISA), while the carotid tunica intima thickness was assessed by Doppler ultrasound.RESULTS: Diabetic rats showed significant increases hs-CRP, IL-12, renin level, and intima thickness (p<0.001) compared to control. Both metformin and combination of Vitamin D and magnesium reduced these parameters, with combination of Vitamin D and magnesium showing the greatest improvement. Carotid intima thickness in the combination of Vitamin D and magnesium group was comparable to normal controls, indicating marked vascular protection.CONCLUSION: Vitamin D and magnesium combination provided superior glycemic, anti-inflammatory, and vascular protective effects compared to metformin alone. This adjunctive strategy might have potential in preventing vascular complications in diabetes.KEYWORDS: diabetes mellitus, oxidative stress, endothelial dysfunction, hs-CRP, IL-12, atherosclerosis
Hubungan Fungsi Kognitif Berdasarkan Skor MMSE dengan Hasil CT Scan Kepala Pasien Lansia Handayani, Damiana Nirmala Mukti; Rahayu, Rachmi Fauziah; Wiyono, Nanang
Smart Medical Journal Vol 4, No 3 (2021): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v4i3.57246

Abstract

Pendahuluan: Penurunan fungsi kognitif merupakan penyebab utama disabilitas dan ketergantungan akan perawatan lansia. Pemeriksaan dengan pencitraan memungkinkan kita untuk mengetahui perubahan struktural otak yang dapat menjadi prediktor munculnya demensia. Penelitian mengenai topik ini masih jarang dilakukan di Indonesia. Oleh karena itu, penelitian ini dilaksanakan untuk mempelajari hubungan antara hasil penilaian fungsi kognitif dengan mini mental state examination (MMSE) dan hasil CT scan kepala pasien lansia, yang distandarisasi dengan kriteria penilaian skala global cortical atrophy (GCA).Metode: Penelitian ini merupakan penelitian kuantitatif dengan metode observasi. Populasi yang diteliti merupakan pasien yang berusia ≥60 tahun, menjalani pemeriksaan CT scan kepala pada tahun 2021, dan mampu menjalani pemeriksaan MMSE selama periode pengambilan data penelitian. Sampel diambil dengan the rule of thumb sebanyak 30 orang. Analisis data dilakukan dengan uji korelasi Rank Spearman.Hasil: Penelitian ini diikuti oleh 18 pasien perempuan dan 12 pasien laki-laki. Sebagian besar pasien memiliki fungsi kognitif yang normal dengan rata-rata skor MMSE 26 (±3,42) dan skala GCA 1 - 2. Terdapat korelasi negatif yang signifikan secara statistik (r=-0,546/p<0,002) antara fungsi kognitif berdasarkan skor MMSE dengan hasil pemeriksaan CT scan kepala pasien lansia.Kesimpulan: Terdapat hubungan negatif berkekuatan moderat antara fungsi kognitif berdasarkan skor MMSE dengan hasil pemeriksaan CT scan kepala pasien lansia.
Co-Authors Abd. Rasyid Syamsuri Adam Fauzi Adam Prabata Anugrah, Tessa Septian Azzahra, Balqis Faizah Brian Wasita Brian Wasita Budianti, Rita Handayani, Damiana Nirmala Mukti Happy Kurnia Permatasari Hari Wujoso Hermansyah, Muhamad Lukman Heru Priyanto Irawan, Amelia Tjandra Kristanto Yuli Yarso Kusumaningrum, Sulistyani LAWEI, THARINA Luths Maharina Maharina, Luths Marissa, Risa Moedigdo, Ambar Muthaminah, Muthaminah Nanang Wiyono Nanang Wiyono Prabata, Adam Putro, Prasetyo Sarwono Ratih Dewi Yudhani Riza Novierta Pesik Riza Novierta Pesik Ropitasari Ropitasari Rospitasari Rospitasari Sholikah, Tri Agusti Siswanto, Febby Gunawan Soegiartiningsih, Soegiartiningsih Soewondo, Widiastuti Subandi Subandi Susianto, Djoko Suyatmi Suyatmi Suyatmi Suyatmi Tifani, Amara Syifa Wardhani, Lusi Oka Yarso, Kristanto Yuli Yuyun Yueniwati Zahrah, Fathimah Afifah