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All Journal Jurnal Kolaboratif Sains Journal of Creative Power and Ambition (JCPA)
Gede Agus Ari Tirtayasa
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Aktivitas Farmakologi Daun Kelor (Moringa oleifera) Sebagai Antiinflamasi (Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory): Pharmacological Activity of Moringa Leaves (Moringa oleifera) as an Anti-Inflammatory Ni Luh Desy Rupadani; I Gusti Ayu Intan Puspita Dewi; Gede Agus Ari Tirtayasa
Jurnal Kolaboratif Sains Vol. 9 No. 1: Januari 2026
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v9i1.10198

Abstract

Daun kelor (Moringa oleifera) telah lama dikenal sebagai obat tradisional di masyarakat. Daun kelor memiliki banyak aktivitas farmakologi salah satunya sebagai antiinflamasi. Penelitian mengenai aktivitas antiinflamasi daun kelor sudah banyak dilakukan, baik secara in vitro maupun in vivo. Terdapat beberapa mekanisme antiinflamasi daun kelor diantaranya penghambatan sintesis prostaglandin, menekan sitokin pro inflamasi, penghambatan denaturasi protein. Tinjauan pustaka ini bertujuan untuk mengevaluasi secara komprehensif bukti penelitian terkini mengenai mekanisme kerja antiinflamasi daun kelor. Pencarian literatur menggunakan database nasional dan internasional seperti pubmed, google scholar, scopus dan lain sebagainya. Uji in vivo menunjukkan potensi daun kelor untuk dikembangkan menjadi sediaan farmasi bahkan dapat dikembangkan untuk dilakukan pengujian klinis kepada manusia.
The use of Red Onion (Allium Cepa L.) Skin Extract as an Antioxidant and Anti-Inflammatory in Rats: A Literature Review Study Gede Agus Ari Tirtayasa; Maria Malida Vernandes Sasadara; Putu Era Sandhi Kusuma Yuda; Erna Cahyaningsih; Ni Luh Kade Arman Anita Dewi
Journal of Creative Power and Ambition (JCPA) Vol. 4 No. 01 (2026): Journal of Creative Power and Ambition (JCPA)
Publisher : CV Edujavare Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70610/jcpa.v4i01.1145

Abstract

Red onion peel (Allium cepa L.) is an agricultural by-product that contains high levels of bioactive compounds, particularly flavonoids and quercetin, which are known to possess antioxidant and anti-inflammatory properties. This systematic literature review aims to analyze the scientific evidence regarding the effects of red onion peel extract on antioxidant and anti-inflammatory activities in mouse models. Data were collected from international databases and selected based on relevance to in vivo and in vitro studies published between 2020 and 2025. The findings indicate that red onion peel extract significantly enhances antioxidant defense mechanisms by increasing the activity of superoxide dismutase (SOD), catalase, and total antioxidant capacity (ORAC), while reducing oxidative stress markers such as nitric oxide (NO) and inducible nitric oxide synthase (iNOS). In addition, the extract exhibits strong anti-inflammatory effects through the suppression of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, as well as inhibition of key signaling pathways such as JAK-STAT, NF-κB, and NLRP3/caspase-1. The effectiveness of the extract is influenced by dosage, duration of administration, and extraction method, with higher doses and longer exposure generally producing stronger biological effects. Overall, red onion peel extract shows promising potential as a natural source of antioxidant and anti-inflammatory agents for nutraceutical and therapeutic applications.
Co-Authors Erna Cahyaningsih I Gusti Ayu Intan Puspita Dewi Maria Malida Vernandes Sasadara Ni Luh Desy Rupadani Ni Luh Kade Arman Anita Dewi Putu Era Sandhi Kusuma Yuda