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All Journal Dentika Dental Journal
Syarida Hasnur binti Syafii
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Dentistry

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Detecting Periodontal Destruction with Saliva Biomarkers in Aging: Systematic Review Pitu Wulandari; Syarida Hasnur binti Syafii; Julia Maharani; Olivia Avriyanti Hanafiah; Irma Ervina; Mutia Amalia Nasution
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.19739

Abstract

Immuno-inflammatory responses to bacteria in dental biofilms can lead to periodontal destruction, which can be indicated by inflammatory markers in saliva. This review highlights salivary biomarkers for detecting periodontal damage as elderly.Two independent reviewers conducted a systematic literature search on PubMed for English publications from 1961 to 2024 using keywords like “aging,” “saliva,” “biomarkers,” and “periodontitis.” The search included only randomized controlled trials that examined salivary biomarkers in aging populations. Out of 160,647 publications, four high-quality studies were included—two from Europe (Switzerland and Slovakia), one from the United States, and one from South Korea. The identified salivary biomarkers included Interleukin-1β, Interleukin-6, matrix metalloproteinases (MMP-3, MMP-8, MMP-9), advanced glycation end products (AGEs), advanced oxidation protein products (AOPP), and total antioxidant capacity (TAC). Based on the published studies, saliva biomarkers are valuable indicators of periodontal disease during aging.
Co-Authors Irma Ervina Julia Maharani Mutia Amalia Nasution Olivia Avriyanti Hanafiah Pitu Wulandari