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All Journal Biology, Medicine, & Natural Product Chemistry
Sipahutar, Feimmy Ruth Pratiwi
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Uncovering the Molecular Mechanisms of Saurauia vulcani Korth in Rhodamine B Induced Colon Injury Sipahutar, Feimmy Ruth Pratiwi; Sinaga, Erlintan; Sinambela, Masdiana; LumbanGaol, Adriana Yulinda Dumaria; Sipahutar, Melati Nugrahalia
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.349-355

Abstract

The illegal food colorant, Rhodamine B (RhB), might lead to chronic colon injury. Saurauia vulcani is an ethnomedicine utilized for hepatoprotection, antioxidants, and immunomodulators. The histopathological and bioinformatic assays were conducted to discover the ethanolic extract of S. vulcani (EEP) against colon damage in RhB-induced rats. The abnormal results were exhibited in RhB administration, while EEP regained colon length and improved the histopathology of the ascending colon in rats. Furthermore, the construction of PPI predicted TP53, SRC, EGFR, AKT1, MTOR, CASP3, ABCG2, CTNNB1, MAPK14, MAPK8, and JUN as the main targets related to chronic colon injury. The molecular interaction presented S. vulcani had the stable fluctuation and strong binding affinities to thymidine phosphorylase. Therefore, this finding could be preliminary data for chronic colon injury treatment.
Co-Authors Lumbangaol, Adriana Yulinda Dumaria Masdiana Sinambela Sinaga, Erlintan Sipahutar, Melati Nugrahalia