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All Journal Biology, Medicine, & Natural Product Chemistry Bioscientist : Jurnal Ilmiah Biologi
Sinaga, Erlintan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Aktivitas Protektif Ekstrak Etanol Daun Ketul (Bidens pilosa L) terhadap Paru-Paru Tikus Putih (Rattus norvegicus) yang Diberi Alkohol Windah, Putri; Silitonga, Melva; Sinaga, Erlintan; Pranoto, Hendro; Pohan, Selvia Dewi
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 3 (2025): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i3.16638

Abstract

This study aims to analyze the protective potential of Bidens pilosa L. leaf ethanol extract against histological damage to the lungs of white rats (Rattus norvegicus) due to alcohol exposure. This study is an experimental research using five treatment groups, consisting of a negative control, a positive control (alcohol), and three groups administered alcohol combined with Bidens pilosa L. leaf ethanol extract (EEDK) at varying doses. The parameters observed include edema, alveolar septum destruction, and inflammatory cell infiltration in lung histology specimens. Data were analyzed using one-way ANOVA followed by DMRT. The results showed that EEDK administration significantly reduced lung damage, as indicated by a decrease in the average damage score from 43.12 ± 0.18 in the alcohol group to 33.92 ± 1.65 (250 mg/kgBW), 23.32 ± 2.18 (500 mg/kgBW), and 14.88 ± 1.06 (750 mg/kgBW). The reduction in lung damage included improvement in edema, reduction in alveolar septal destruction, and suppression of inflammatory cell infiltration. These findings suggest that ethanol extract of Bidens pilosa L. leaves has potential as a natural protective agent through its anti-inflammatory and antioxidant activities, thereby potentially useful for preventing or reducing alcohol-induced lung damage.
Uncovering the Molecular Mechanisms of Saurauia vulcani Korth in Rhodamine B Induced Colon Injury Sipahutar, Feimmy Ruth Pratiwi; Sinaga, Erlintan; Sinambela, Masdiana; LumbanGaol, Adriana Yulinda Dumaria; Sipahutar, Melati Nugrahalia
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.349-355

Abstract

The illegal food colorant, Rhodamine B (RhB), might lead to chronic colon injury. Saurauia vulcani is an ethnomedicine utilized for hepatoprotection, antioxidants, and immunomodulators. The histopathological and bioinformatic assays were conducted to discover the ethanolic extract of S. vulcani (EEP) against colon damage in RhB-induced rats. The abnormal results were exhibited in RhB administration, while EEP regained colon length and improved the histopathology of the ascending colon in rats. Furthermore, the construction of PPI predicted TP53, SRC, EGFR, AKT1, MTOR, CASP3, ABCG2, CTNNB1, MAPK14, MAPK8, and JUN as the main targets related to chronic colon injury. The molecular interaction presented S. vulcani had the stable fluctuation and strong binding affinities to thymidine phosphorylase. Therefore, this finding could be preliminary data for chronic colon injury treatment.
Co-Authors Lumbangaol, Adriana Yulinda Dumaria Masdiana Sinambela Melva Silitonga Pranoto, Hendro Selvia Dewi Pohan Sipahutar, Feimmy Ruth Pratiwi Sipahutar, Melati Nugrahalia Windah, Putri