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All Journal Biology, Medicine, & Natural Product Chemistry Best Journal (Biology Education, Sains and Technology)
Lumbangaol, Adriana Yulinda Dumaria
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Efek Kardioprotektif Ekstrak Etanol Daun Rambusa (Passiflora foetida L.) Pada Tikus Putih (Rattus norvegicus) Yang Diinduksi Aloksan Samosir, Naomi Angel; Lumbangaol, Adriana Yulinda Dumaria
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.12196

Abstract

Gangguan kardiovaskular merupakan penyebab kematian paling umum pada penderita diabetes. Obat oral seringkali menimbulkan efek samping, sehingga tanaman obat digunakan karena biasanya memiliki risiko lebih rendah, salah satunya adalah tanaman rambusa (Passiflora foetida L.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian Ekstrak Etanol Daun Rambusa (EEDR) terhadap perbaikan kerusakan sel pada jantung tikus setelah diinduksi aloksan 120 mg/kgBB. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari 6 kelompok dan 5 kali ulangan. Kelompok P1 (kontrol normal), kelompok P2 (kontrol negatif/aloksan 120 mg/kg BB), kelompok P3 (aloksan 120 mg/kg BB + metformin 45 mg/kg BB), kelompok P4 (aloksan 120 mg/kg BB + EEDR 100 mg/kg BB), kelompok P5 (aloksan 120 mg/kg BB + EEDR 200 mg/kg BB), dan kelompok P6 (aloksan 120 mg/kg BB + EEDR 400 mg/kg BB). Data skor jantung dianalisis menggunakan ANOVA Satu Arah dan dilanjutkan dengan uji DMRT. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun rambusa berpengaruh nyata terhadap histopatologi jantung tikus. Perbaikan kerusakan jantung yang paling efektif ditemukan pada kelompok P6 dengan dosis 400 mg/kg BB karena menunjukkan penurunan nekrosis sel miosit sebesar 14% dari seluruh sel yang diamati dan sama dengan kelompok P3. Kesimpulan penelitian ini adalah pemberian ekstrak etanol daun rambusa dengan dosis 400 mg/kg BB dapat memberikan efek kardioprotektif, ditandai dengan penurunan jumlah nekrosis sel miosit yang mendekati kelompok kontrol normal.
The Ameliorative Effect of Apigenin in Plectranthus amboinicus Lour Spreng in the Treatment of Hepato-renal Carcinogenesis Induced Benzo(a)pyrene Silitonga, Melva; Pranoto, Hendro; Sinaga, Erlintan; Sipahutar, Feimmy Ruth Pratiwi; LumbanGaol, Adriana Yulinda Dumaria; Sinaga, Fajar Apollo
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1483-1490

Abstract

Benzo(a)pyrene (B(a)P) is the major cause of hepato-renal carcinogenesis. Apigenin in Plectranthus amboinicus (EPA), has indicated some biological activities such as antioxidant and antimutagenic activity. The aim of this study is to investigate the potential of apigenin in EPA as anti-cancer against chronic hepatorenal damage exposed to B(a)P. The rats of 4 groups (n=6) were divided as follows: Group I (P0) was given food and water ad-libitum; Group II (PB) was administered orally B(a)P 2 mg/kg BW; Group III (PB+E) received orally B(a)P 2 mg/kg BW and EPA 500 mg/kg; Group IV (PE) was administered orally EPA 500 mg/kg BW. The therapeutic effect of EPA was explored using network pharmacology and molecular docking. The results showed that Group III could significantly improve (P < 0.05) the hepatorenal function parameter, including DNA concentration. SGPT, SGOT, blood urea nitrogen, and creatinine compared to those treated with B(a)P. The outcome data pharmacology revealed 6 targets could be the main core target. The good binding affinity indicated Apigenin docked to AKT1 protein with -10.00 kcal/mol relevant to Doxorubicin as control drug. Our results provide a new insight of apigenin in EPA potentially suppressing the regulation of chemical carcinogenesis by B(a)P.
Co-Authors Melva Silitonga Pranoto, Hendro Samosir, Naomi Angel Sinaga, Erlintan Sipahutar, Feimmy Ruth Pratiwi