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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan dr. Soebandi
Kintoko Kintoko
Ahmad Dahlan University
Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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In Silico Study of Bioactive Compounds of Betel (Piper Betle) as Antidiarrhea Assisted by Liquid Chromatography – Mass Spectroscopy Khrisna Cendekiawan; Kintoko Kintoko; Sapto Yuliani; Linda Suci Anggraeni; Lailatul Fitria Ningrum; Siti Nur Hasana; Firda Aprillia Wardhani
Jurnal Kesehatan dr. Soebandi Vol 13 No 2 (2025): Vol. 13 No. 2 (2025): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v13i2.975

Abstract

Diarrhea is a condition where feces are produced that are abnormal or not as usual. . The betel plant (Piper betle L.) is a plant that creeps, climbs and has woody bushes at the base and has a length of up to 15 m. The aim of this research is toexploring the active compounds in methanol extract of the betel plant (Piper betle)The main content that is useful as an antidiarrheal includes flavonoids, tannins, essential oils and alkaloids, where flavonoids, especially quercetin, can inhibit the release of acetylcholine and intestinal contractions.The research stages of the analysis of the potential of compounds in betel leaves (Piper betle) in silico consist of ligand preparation, receptor preparation, Lipinski prediction, and amino acid interactions. The software used is the PubChem website, rscb, while the software is Autodock Tools, and Discovery Studio Client 4.1. The results of the study showed thatThe binding energy value of quercetin can be said to be good, namely -9.72.For the interaction of quercetin amino acid residues, there is a similarity, namely located at VAL:209 with the native ligand.Besides thatThe RMSD value of the native ligand is 1.83 Å. This study concludes that quercetin meets the criteria as a candidate compound for antidiarrhea drugs contained in betel leaves.
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Khrisna Agung Cendekiawan; Kintoko Kintoko; Sapto Yuliani; Linda Suci Anggraeni; Firdha Aprillia Wardhani; Neny Poerwahyuningrum
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
Co-Authors Firda Aprillia Wardhani Khrisna Agung Cendekiawan Khrisna Cendekiawan Lailatul Fitria Ningrum Linda Suci Anggraeni Linda Suci Anggraeni Neny Poerwahyuningrum Sapto Yuliani Sapto Yuliani Siti Nur Hasana Wardhani, Firdha Aprillia