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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Indri J. Kereh
Department of Biology, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Inhibitory Activity of Sea Grapes (Caulerpa racemosa) Against the Growth of Propionibacterium acnes Yessie K. Lengkey; Indri J. Kereh; Sonny D. Untu; Margaretha S. Ginting; Ferdy A. Karauwan; Selvana S. Tulandi; Adolfina Sumagando
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 2 (2025): OKTOBER 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i2.524

Abstract

This study aimed to determine the inhibitory activity of sea grapes (Caulerpa racemosa) against the growth of Propionibacterium acnes, a bacterium that can cause acne on human skin. Sea grapes contain bioactive compounds such as flavonoids and alkaloids which may act as natural antibacterial agents. This research was conducted experimentally in the laboratory using the agar diffusion method with paper discs. The sea grape sample was extracted by maceration using 96% ethanol and tested at concentrations of 100, 200, 300, and 400 µg/disc. Distilled water was used as a negative control. The results showed that the extract was able to inhibit the growth of Propionibacterium acnes, with inhibition zone diameters ranging from 33.9 to 41.2 mm. The largest inhibition zone was found at the concentration of 400 µg/disc. In conclusion, sea grapes (Caulerpa racemosa) have very strong antibacterial activity against Propionibacterium acnes and have potential as a natural antibacterial source.
Co-Authors Adolfina Sumagando Ferdy A. Karauwan Margaretha S. Ginting Selvana S. Tulandi Sonny D. Untu Yessie K. Lengkey