Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal Science Midwifery KESANS : International Journal of Health and Science
Karina Shasri Anastasya
Universitas Trisakti, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Physics Public Health Veterinary

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population Monica Dwi Hartanti; Ilham Hizbulloh; Janice Puteri Satibi; Ricardo Lie Virgo; Karina Shasri Anastasya; Mizanul Adli; Gerie Amarendra; Agung Junnata
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3472

Abstract

BACKGROUND: Apolipoprotein A (APOA)2–265 T>C polymorphism significantly affects lipid metabolism and body composition, as well as plays a key role in cardiovascular diseases (CVD) and metabolic syndrome. In this study, association between the APOA2 polymorphism, lipid profiles, body composition, and cardiovascular disease (CVD) risk in a healthy Indonesian population was investigated. Although similar studies have been conducted in other populations, this study addresses the urgent need to understand genetic factors influencing lipid profiles in Southeast and East Asia, where hypercholesterolemia rate keep rising, particularly in Indonesia.METHODS: A cross-sectional study involving 84 healthy participants was performed. Genotyping for the APOA2–265 T>C polymorphism was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma levels of APOA2 and APOB100 were measured with enzyme-linked immunosorbent assay (ELISA), and APOB100/APOA2 ratio was calculated to assess CVD risk. Lipid profiles were evaluated with enzymatic methods, and body fat percentage was measured using calipers.RESULTS: CT/CC genotypes showed significantly lower plasma APOA2 levels compared to the TT genotype (p=0.0215). APOB100/APOA2 ratio was significantly higher in CT/CC genotypes (p=0.0020) and remained significant after Bonferroni correction. No significant differences were found in lipid profiles and body fat percentages between genotypes after correction, although trends suggested higher cholesterol and low-density lipoprotein (LDL) levels in TT genotypes and higher median body fat percentages in CC/CT genotypes.CONCLUSION: APOA2–265 T>C polymorphism is linked to changes in lipid profiles and body composition, potentially raising CVD risk in CT/CC genotypes. However, limited sample size and modest effect sizes suggest that the practical use of APOA2 genotyping for risk assessment might require further investigation.KEYWORDS: APOA2 polymorphism, APOB100, hypercholesterolemia, cardiovascular disease, lipid profile, body fat percentage
Serum 25-hydroxyvitamin D is associated with body fat percentage and skeletal muscle mass in adults: A cross-sectional study Meutia Atika Faradilla; Deasyka Yastani; Yohana Yohana; Karina Shasri Anastasya; Nabila Maudy Salma
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2253

Abstract

Background: Vitamin D is widely recognized for its role in bone and musculoskeletal health, yet accumulating evidence suggests it may also influence body composition through regulatory effects on adipose and skeletal muscle tissues. This study aimed to evaluate the association between serum vitamin D status and body composition parameters in adults. Methods: A cross-sectional study was conducted in 77 adults. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using an enzyme-linked immunosorbent assay (ELISA), while body composition (percent body fat and skeletal muscle mass) was assessed using bioelectrical impedance analysis (BIA). Participants were categorized based on vitamin D status, and group comparisons as well as Pearson correlation analyses were performed. Results: The mean age of participants was 35.8 ± 9.6 years, and 40.2% were men. The prevalence of vitamin D deficiency (<20 ng/mL) was 36%, while 68% of participants had suboptimal vitamin D levels (deficiency or insufficiency). Individuals with vitamin D deficiency showed significantly higher body fat percentage and lower skeletal muscle mass compared with the non-deficient group (p < 0.05). Serum 25(OH)D was moderately inversely correlated with body fat percentage (r = −0.41, p = 0.018) and positively correlated with skeletal muscle mass (r = 0.29, p = 0.012). Conclusion: Lower vitamin D status was associated with increased adiposity and reduced skeletal muscle mass in adults. These findings highlight the potential importance of maintaining adequate vitamin D levels as part of strategies supporting healthier body composition. Longitudinal and interventional studies are needed to clarify causality and clinical implications.
Prolonged Activated Partial Thromboplastin Time in Adults with Nephrotic Syndrome: A Case Report Mutiara Ferina; Alvina Alvina; Karina Shasri Anastasya; Deasyka Yastani; Andira Larasari; Rima Anindita Primandari
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 10 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i10.689

Abstract

Introduction: Nephrotic syndrome is classically associated with a hypercoagulable state driven by the compensatory hepatic overproduction of procoagulant proteins and platelet hyperreactivity. However, massive proteinuria can rarely disrupt this paradigm, inducing a paradoxical bleeding diathesis that presents a significant clinical challenge. Discussion: A 22-year-old man presented to the emergency department with a two-week history of generalized edema and a recent onset of melena. Laboratory investigations revealed profound hypoalbuminemia (1.1 g/dL) and extraordinary, massive nephrotic-range proteinuria (63.42 g/24 h), accompanied by dyslipidemia and anemia. Coagulation profiling demonstrated a significantly prolonged activated partial thromboplastin time (aPTT) of 51.4 seconds, confirming an active upper gastrointestinal hemorrhage in the setting of ultra-severe nephrotic. He was treated with methylprednisolone, furosemide, candesartan, and simvastatin, together with albumin transfusion for severe hypoalbuminemia. Conclusion: This case highlights a rare hemorrhagic paradox in nephrotic syndrome and underscores the importance of prompt coagulation workup, including a mixing study, when bleeding occurs in a condition typically considered prothrombotic
Co-Authors Agung Junnata Alvina Alvina Andira Larasari Deasyka Yastani Deasyka Yastani Gerie Amarendra Ilham Hizbulloh Janice Puteri Satibi Meutia Atika Faradilla Mizanul Adli Monica Dwi Hartanti Mutiara Ferina Nabila Maudy Salma Ricardo Lie Virgo Rima Anindita Primandari Yohana Yohana