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All Journal The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal SOLMA The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Gerie Amarendra
Department Of Internal Medicine, Faculty Of Medicine, Universitas Trisakti, Jakarta Barat, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health Other

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Potassium Competitive Acid Blockers: A New Paradigm For The Management of Stomach Acid Disorders Gerie Amarendra; Wawan Kurniawan; Mizanul Adli
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.164

Abstract

Proton pump inhibitors (PPIs) are the main therapy for stomach acid disorders to date. The disadvantage of PPI is the difficulty of controlling symptoms at night, such as tightness, chest pain, and coughing cough. Potassium competitive acid blockers (P-CAB) are a new class in the management of stomach acid disorders. Potassium competitive acid blockers work by a different mechanism, which binds non-covalently to H+/K+-ATPase. This mechanism results in a faster, stronger, and long-lasting suppression effect of gastric acid production. Besides being able to cure gastric complaints at night, P-CAB increases the success of Helicobacter pylori eradication. The safety of the use of this P_CAB drug, according to research is quite mild and acceptable. Currently, examples of P-CAB groups on the market are vonoprazan and tegoprazan. This narrative review is intended to provide further insight into this potassium competitive acid blocker (P-CAB) class of drugs.
APOA2–265 T>C Polymorphism as A Genetic Marker Associated with Lipid Profiles and Cardiovascular Risk in A Healthy Indonesian Population Monica Dwi Hartanti; Ilham Hizbulloh; Janice Puteri Satibi; Ricardo Lie Virgo; Karina Shasri Anastasya; Mizanul Adli; Gerie Amarendra; Agung Junnata
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3472

Abstract

BACKGROUND: Apolipoprotein A (APOA)2–265 T>C polymorphism significantly affects lipid metabolism and body composition, as well as plays a key role in cardiovascular diseases (CVD) and metabolic syndrome. In this study, association between the APOA2 polymorphism, lipid profiles, body composition, and cardiovascular disease (CVD) risk in a healthy Indonesian population was investigated. Although similar studies have been conducted in other populations, this study addresses the urgent need to understand genetic factors influencing lipid profiles in Southeast and East Asia, where hypercholesterolemia rate keep rising, particularly in Indonesia.METHODS: A cross-sectional study involving 84 healthy participants was performed. Genotyping for the APOA2–265 T>C polymorphism was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma levels of APOA2 and APOB100 were measured with enzyme-linked immunosorbent assay (ELISA), and APOB100/APOA2 ratio was calculated to assess CVD risk. Lipid profiles were evaluated with enzymatic methods, and body fat percentage was measured using calipers.RESULTS: CT/CC genotypes showed significantly lower plasma APOA2 levels compared to the TT genotype (p=0.0215). APOB100/APOA2 ratio was significantly higher in CT/CC genotypes (p=0.0020) and remained significant after Bonferroni correction. No significant differences were found in lipid profiles and body fat percentages between genotypes after correction, although trends suggested higher cholesterol and low-density lipoprotein (LDL) levels in TT genotypes and higher median body fat percentages in CC/CT genotypes.CONCLUSION: APOA2–265 T>C polymorphism is linked to changes in lipid profiles and body composition, potentially raising CVD risk in CT/CC genotypes. However, limited sample size and modest effect sizes suggest that the practical use of APOA2 genotyping for risk assessment might require further investigation.KEYWORDS: APOA2 polymorphism, APOB100, hypercholesterolemia, cardiovascular disease, lipid profile, body fat percentage
Peningkatan Pengetahuan dan Keterampilan dalam Penyusunan Diet untuk Mencegah Hipertensi pada Masyarakat Desa Ciangsana Yenny Yenny; Patricia Budihartanti Liman; Kartini Kartini; Gerie Amarendra; Erni Erfan; Najwa Ali; Nahla Sarita Husein; Alzikha Khalisha Roza
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.21123

Abstract

Latar Belakang: Hipertensi merupakan penyakit tidak menular yang dapat diatasi dengan perubahan gaya hidup dan deteksi dini. Data  menunjukkan masih tingginya kejadian hipertensi dan rendahnya kesadaran masyarakat Desa Ciangsana melakukan skrining. Tujuan: Meningkatkan pengetahuan dan keterampilan tentang hipertensi melalui pelatihan dengan pendekatan DASH (Dietary Approaches to Stop Hypertension) pada masyarakat Metode: Skrining kesehatan, penyuluhan interaktif, demonstrasi, pendampingan penyusunan menu, diskusi interaktif diguanakan sebagai metode. Data karakteristik sosiodemografik, antropometrik,tekanan darah, dan gula darah puasa dikumpulkan. Peningkatan pengetahuan dan keterampilan responden dianalisis dengan uji Wilcoxon signed rank. Hasil: mayoritas responden berjenis kelamin perempuan 28 (93,3%), median usia 45 (27 – 70) tahun, dengan tingkat pendidikan rendah yaitu 13 (56,7%) responden. Pada pemeriksaan fisik ditemukan mayoritas responden memiliki indeks massa tubuh obesitas yaitu 24 (80,0%) responden, obesitas sentral yaitu 19 (63,3%) responden, hipertensi yaitu 10 (33,3%) responden, di mana 6 responden diantaranya tidak rutin minum obat. Terdapat peningkatan pengetahuan dan keterampilan responden yang dilihat adanya peningkatan median (min – max)  jawaban benar  pasca kegiatan secara bermakna dari  8,5 (0 – 11) dan 10 (7 – 11); p<0.001. Kesimpulan: Kegiatan pengabdian masyarakat menghasilkan peningkatan pengetahuan dan keterampilan responden tentang hipertensi. Tingginya angka obesitas dan obesitas sentral memerlukan deteksi dini dan edukasi berkelanjutan untuk mengontrol risiko hipertensi. Untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam kontinuitas, kolaborasi tenaga medis dan pemerintah setempat diperlukanprogaram kegiatan.
Colonic Leiomyoma Presenting as Sigmoid Volvulus in a Young Male Reza Aditya Digambiro; Gerie Amarendra; Florinda Ilona; Julian Chendrasari; Samuel Abiodun Kehinde
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202695-100

Abstract

Colonic leiomyomas are rare tumors that originate from the smooth muscle layer of the colon and are infrequently observed in young individuals. This case report represents a 21-year-old male who presented with a 2-month history of progressive abdominal distension, persistent vomiting, early satiety, and bloating. Computed tomography (CT) of the abdomen suggested sigmoid volvulus with associated bowel obstruction. However, exploratory laparotomy revealed a well-defined, firm intramural mass in the sigmoid colon, leading to segmental resection and primary anastomosis. Histopathological analysis showed intersecting fascicles of bland spindle cells with eosinophilic cytoplasm and cigar-shaped nuclei without atypia or mitotic activity. Immunohistochemistry confirmed positivity for smooth muscle actin (SMA) and negativity for CD117, supporting a diagnosis of colonic leiomyoma and excluding gastrointestinal stromal tumor (GIST). The patient’s postoperative course was uneventful, with complete resolution of obstructive symptoms and restoration of normal bowel function. This case highlights the diagnostic challenge of differentiating colonic leiomyoma from other causes of bowel obstruction, particularly when presenting with features mimicking sigmoid volvulus. It also emphasizes the critical role of histopathology and immunohistochemistry in establishing a definitive diagnosis. Clinicians should consider rare benign tumors in the differential diagnosis of young patients with signs of bowel obstruction.
Co-Authors Agung Junnata Alzikha Khalisha Roza Erni Erfan, Erni Florinda Ilona Ilham Hizbulloh Janice Puteri Satibi Julian Chendrasari Karina Shasri Anastasya Kartini Kartini Mizanul Adli Mizanul Adli Monica Dwi Hartanti Nahla Sarita Husein Najwa Ali Patricia Budihartanti Liman Reza Aditya Digambiro Ricardo Lie Virgo Samuel Abiodun Kehinde Yenny Yenny