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All Journal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Journal of Innovative and Creativity Jurnal Sains Farmasi dan Kesehatan
Razoki
Universitas Prima Indonesia
Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN TEMU MANGGA (CURCUMA MANGGA VALETON) Dewi Ayu Puspita; Razoki; Hariyadi Dharmawan Syahputra
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7112

Abstract

Keanekaragaman hayati Indonesia mencakup temu mangga (Curcuma mangga Val.) yang ekstrak etanol daunnya berpotensi farmakologis namun menghadapi tantangan stabilitas dalam bentuk tradisional. Penelitian eksperimental laboratorium berpendekatan kuantitatif ini bertujuan memformulasikan sediaan mikroenkapsulasi metode gelasi ionik (konsentrasi 0,25%, 0,5%, 0,75%) dan mengevaluasi karakteristik fisik meliputi stabilitas, kadar air, dan daya lekat. Populasi daun temu mangga dari Medan (1.100 g simplisia, rendemen 12,2%) diambil sampel purposif menjadi empat formulasi memenuhi kriteria inklusi (bentuk bulat/oval, permukaan halus). Instrumen mencakup rotary evaporator, syringe 22G, oven pengering, dengan teknik analisis skrining fitokimia, cycling test, perhitungan kadar air, dan uji daya lekat mukosa lambung tikus. Hasil menunjukkan rendemen 12,2%, fitokimia positif (alkaloid, flavonoid, saponin, terpenoid, steroid, fenol), stabilitas organoleptik enam siklus, kadar air 0,75-1,34%, dan daya lekat hingga 120 menit. Simpulan menyatakan mikroenkapsulasi natrium alginat-kitosan menghasilkan sediaan herbal stabil ber-kadar air rendah dan mukoadhesi baik, potensial untuk pengembangan farmasi modern.
Evaluation of Microencapsulation Formulation of Breadfruit (Artocarpus Altilis L) Ethanol Extract Yessy Yusnita Gracela Tambunan; Razoki; Daimah Wirdartus Sanaun Harahap
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 13 No. 1 (2026): Jurnal Kesehatan
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v13i1.1004

Abstract

Microencapsulation is one of the pharmaceutical technologies used to enhance the stability and effectiveness of herbal active compounds. This study aims to evaluate the formulation of microencapsulated preparations of ethanol extract from breadfruit leaves (Artocarpus altilis L.) using a chitosan–alginate polymer system. The research was conducted experimentally in vitro by preparing microcapsules with extract concentrations of 0.25%, 0.5%, and 0.75%, followed by evaluations including stability testing, moisture content, and floating tests in the rat stomach. The results showed that all formulations were physically stable without any changes in color, shape, odor, or texture over six temperature cycles. The moisture content of the microcapsules ranged from 0.63% to 12.34%, with the lowest value observed at the 0.75% concentration. Floating tests indicated that all formulations had a floating lag time of less than 2 minutes, with the longest floating duration of up to 8 hours at the 0.75% concentration. Based on these results, microencapsulation of breadfruit leaf ethanol extract at a concentration of 0.75% is considered the best formulation and has the potential to be developed as a gastroretentive pharmaceutical preparation.
Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih Devortivo Hartono Putra; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3399

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.
Co-Authors Daimah Wirdartus Sanaun Harahap Devortivo Hartono Putra Dewi Ayu Puspita Erida Novriani Hariyadi Dharmawan Syahputra Yessy Yusnita Gracela Tambunan