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All Journal MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Innovative and Creativity
Hariyadi Dharmawan Syahputra
Universitas Prima Indonesia
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN TEMU MANGGA (CURCUMA MANGGA VALETON) Dewi Ayu Puspita; Razoki; Hariyadi Dharmawan Syahputra
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7112

Abstract

Keanekaragaman hayati Indonesia mencakup temu mangga (Curcuma mangga Val.) yang ekstrak etanol daunnya berpotensi farmakologis namun menghadapi tantangan stabilitas dalam bentuk tradisional. Penelitian eksperimental laboratorium berpendekatan kuantitatif ini bertujuan memformulasikan sediaan mikroenkapsulasi metode gelasi ionik (konsentrasi 0,25%, 0,5%, 0,75%) dan mengevaluasi karakteristik fisik meliputi stabilitas, kadar air, dan daya lekat. Populasi daun temu mangga dari Medan (1.100 g simplisia, rendemen 12,2%) diambil sampel purposif menjadi empat formulasi memenuhi kriteria inklusi (bentuk bulat/oval, permukaan halus). Instrumen mencakup rotary evaporator, syringe 22G, oven pengering, dengan teknik analisis skrining fitokimia, cycling test, perhitungan kadar air, dan uji daya lekat mukosa lambung tikus. Hasil menunjukkan rendemen 12,2%, fitokimia positif (alkaloid, flavonoid, saponin, terpenoid, steroid, fenol), stabilitas organoleptik enam siklus, kadar air 0,75-1,34%, dan daya lekat hingga 120 menit. Simpulan menyatakan mikroenkapsulasi natrium alginat-kitosan menghasilkan sediaan herbal stabil ber-kadar air rendah dan mukoadhesi baik, potensial untuk pengembangan farmasi modern.
ANTIOXIDANT CREAM FORMULATION OF PORANG TUBER ETHANOL EXTRACT AS AN ANTI-AGING AGENT Ain Naia; Roy Indrianto Bangar; Hariyadi Dharmawan Syahputra
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v7i2.292

Abstract

Irreversible skin aging begins in early adulthood due to intrinsic factors such as genetics and cellular metabolism and extrinsic factors such as ultraviolet exposure, smoking, pollution, and lifestyle, which trigger reactive oxygen species (ROS) and collagen damage, leading to wrinkles and reduced skin elasticity. This study aimed to formulate an optimal anti-aging cream from ethanol extract of porang tubers (Amorphophallus muelleri Blume) using variations in the HLB value of Span 60-Tween 80 emulsifiers. This quantitative experimental study used three cream formulas (F1: HLB 4.95; F2: HLB 5.7; F3: HLB 6.8) prepared from 3 kg of porang tubers obtained from Sirapit, Langkat. Evaluations included organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, cycling-test stability, irritation, preference, and antioxidant activity using the DPPH method. The results showed that F2 was the optimal formula, with medium viscosity, spreadability of 6.2 cm², pH 5.8, stability for six cycles, and an IC₅₀ value of approximately 114 μg/mL, indicating moderate antioxidant activity. Formula F2 therefore has potential as a topical antioxidant preparation for preventing premature skin aging based on locally sourced tropical material.
Co-Authors Ain Naia Dewi Ayu Puspita Razoki Roy Indrianto Bangar