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All Journal MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Journal of Pharmaceutical and Sciences. Journal of Innovative and Creativity Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Hariyadi Dharmawan Syahputra
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN TEMU MANGGA (CURCUMA MANGGA VALETON) Dewi Ayu Puspita; Razoki; Hariyadi Dharmawan Syahputra
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7112

Abstract

Keanekaragaman hayati Indonesia mencakup temu mangga (Curcuma mangga Val.) yang ekstrak etanol daunnya berpotensi farmakologis namun menghadapi tantangan stabilitas dalam bentuk tradisional. Penelitian eksperimental laboratorium berpendekatan kuantitatif ini bertujuan memformulasikan sediaan mikroenkapsulasi metode gelasi ionik (konsentrasi 0,25%, 0,5%, 0,75%) dan mengevaluasi karakteristik fisik meliputi stabilitas, kadar air, dan daya lekat. Populasi daun temu mangga dari Medan (1.100 g simplisia, rendemen 12,2%) diambil sampel purposif menjadi empat formulasi memenuhi kriteria inklusi (bentuk bulat/oval, permukaan halus). Instrumen mencakup rotary evaporator, syringe 22G, oven pengering, dengan teknik analisis skrining fitokimia, cycling test, perhitungan kadar air, dan uji daya lekat mukosa lambung tikus. Hasil menunjukkan rendemen 12,2%, fitokimia positif (alkaloid, flavonoid, saponin, terpenoid, steroid, fenol), stabilitas organoleptik enam siklus, kadar air 0,75-1,34%, dan daya lekat hingga 120 menit. Simpulan menyatakan mikroenkapsulasi natrium alginat-kitosan menghasilkan sediaan herbal stabil ber-kadar air rendah dan mukoadhesi baik, potensial untuk pengembangan farmasi modern.
ANTIOXIDANT CREAM FORMULATION OF PORANG TUBER ETHANOL EXTRACT AS AN ANTI-AGING AGENT Ain Naia; Roy Indrianto Bangar; Hariyadi Dharmawan Syahputra
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59733/medalion.v7i2.292

Abstract

Irreversible skin aging begins in early adulthood due to intrinsic factors such as genetics and cellular metabolism and extrinsic factors such as ultraviolet exposure, smoking, pollution, and lifestyle, which trigger reactive oxygen species (ROS) and collagen damage, leading to wrinkles and reduced skin elasticity. This study aimed to formulate an optimal anti-aging cream from ethanol extract of porang tubers (Amorphophallus muelleri Blume) using variations in the HLB value of Span 60-Tween 80 emulsifiers. This quantitative experimental study used three cream formulas (F1: HLB 4.95; F2: HLB 5.7; F3: HLB 6.8) prepared from 3 kg of porang tubers obtained from Sirapit, Langkat. Evaluations included organoleptic properties, homogeneity, pH, viscosity, spreadability, adhesiveness, cycling-test stability, irritation, preference, and antioxidant activity using the DPPH method. The results showed that F2 was the optimal formula, with medium viscosity, spreadability of 6.2 cm², pH 5.8, stability for six cycles, and an IC₅₀ value of approximately 114 μg/mL, indicating moderate antioxidant activity. Formula F2 therefore has potential as a topical antioxidant preparation for preventing premature skin aging based on locally sourced tropical material.
Uji Efektivitas Nefroprotektif Ekstrak Buah Kersen (Muntingia calabura L.) Terhadap Histopatologi Dan Penanda Inflamasi Pada Tikus Putih Yang Diinduksi Gentamicin Superman Jaya Hulu; Asyrun Alkhairi Lubis; Hariyadi Dharmawan Syahputra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1397

Abstract

Background: Kidney disease remains a major global health problem, one of which is associated with the use of nephrotoxic drugs such as gentamicin. Gentamicin induces renal damage through oxidative stress and inflammatory mechanisms. Muntingia calabura L. fruit contains bioactive compounds, including flavonoids and phenolic substances, which are believed to have nephroprotective properties. Objective: This study aimed to evaluate the nephroprotective effectiveness of Muntingia calabura fruit extract on renal histopathological changes and inflammatory markers in gentamicin-induced rats. Methods: This experimental laboratory study employed a post-test only control group design. A total of 25 male white rats were divided into five groups: negative control (0.5% CMC-Na), positive control (gentamicin 80 mg/kg BW), and three treatment groups receiving gentamicin 80 mg/kg BW combined with graded doses of Muntingia calabura fruit extract (50, 100, and 200 mg/kg BW) orally for 7 days. Renal histopathology was examined using hematoxylin-eosin (HE) staining, while serum interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: Administration of Muntingia calabura fruit extract significantly reduced IL-6 levels and improved renal histopathological features compared to the positive control group (p < 0.05). The nephroprotective effect increased in a dose-dependent manner, with the highest dose (200 mg/kg BW) showing renal conditions closest to normal. Conclusion: Muntingia calabura fruit extract has potential as a natural nephroprotective agent against gentamicin-induced nephrotoxicity through inhibition of inflammatory response as indicated by decreased IL-6 levels.
Uji Efektivitas Nefroprotektif Ekstrak Buah Kopi (Coffea Arabica L) Terhadap Perubahan Morfologi Ginjal dan Tumor Necrosis Factor-Alpha (TNF- α) pada Tikus yang Diinduksi Gentamisin Maria Ulfah Siregar; Asyrun Alkhari Lubis; Hariyadi Dharmawan Syahputra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1424

Abstract

Background: Gentamicin is a nephrotoxic antibiotic that induces kidney damage through oxidative stress and elevated TNF-α levels. Coffee fruit (Coffea arabica L.) contains bioactive compounds such as polyphenols and chlorogenic acid with potential nephroprotective effects. Objective: This study aimed to evaluate the nephroprotective efficacy of coffee fruit extract on renal morphological changes and TNF-α levels in gentamicin-induced rats. Methods: An experimental randomized group design was employed using 30 male Wistar rats divided into five groups: normal control, negative control (gentamicin 100 mg/kgBW), and three treatment groups receiving gentamicin plus coffee fruit extract at doses of 100, 200, and 400 mg/kgBW. Parameters assessed included renal histopathological changes (HE staining) and serum TNF-α levels (ELISA). Results: Administration of coffee fruit extract significantly improved renal tubular morphology and reduced TNF-α levels compared to the negative control group (p<0.05). The most protective effect was observed at a dose of 200 mg/kgBW. Conclusion: Coffee fruit extract exhibits nephroprotective activity against gentamicin-induced kidney injury, as evidenced by improved histological structure and reduced TNF-α levels, suggesting its potential as a natural agent for preventing nephrotoxicity.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Glory Stevi Natasia Saragih; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7052

Abstract

Microencapsulation is a technology that uses controlled release of active ingredients to increase bioavailability and reduce gastrointestinal irritation. This study aims to evaluate the microencapsulation formulation of ethanol extract of papaya leaf (Carica papaya L.) by testing its stability, moisture content, and floating in the stomach and intestinal medium. Mardikasari et al (2020) showed the release of chitosan-alginate microencapsulation of 8,811 mg/L (acid) and 79,908 mg/L (base). Microencapsulation was performed by adding sodium alginate and chitosan as polymers, CaCl2 as a cross-linking, and three variations of extract concentration in F1 without extract, F2 of 0,25%, F3 of 0,5%, and F4 of 0,75%. The results showed that all formulas remained stable during the storage cycle in terms of color, aroma, taste, and texture. The average moisture content of the microencapsulated formulations was 24%, 20,5%, 28%, and 18,7%. The microencapsulated preparations were able to maintain their stability in the acidic conditions in the stomach, but showed a decrease in floating under acidic conditions in the intestine.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.) Rika Mai Dinasari Br Sembiring; Razoki Razoki; Erida Novriani; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7054

Abstract

This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
Co-Authors Ain Naia Asyrun Alkhairi Lubis Asyrun Alkhari Lubis Dewi Ayu Puspita Erida Novriani Glory Stevi Natasia Saragih Maria Ulfah Siregar Muhammad Yunus Razoki Razoki Razoki Rika Mai Dinasari Br Sembiring Roy Indrianto Bangar S Superman Jaya Hulu