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All Journal Jurnal Ners Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia
Ardina Malika
Universitas Bakti Tunas Husada
Religion Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing

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The role of medical chemistry in the synthesis of selective anticancer compounds for breast cancer with a computational and experimental approach Saeful Amin; Nikeu Rahayu; Hana Nurhanifah; Anggi Zulvana; Syamsiati Dwi; Ardina Malika
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44374

Abstract

Breast cancer is a cancer with high prevalence in women and requires more selective therapy and minimal side effects. Medicinal chemistry plays an important role in the development of anticancer compounds through a chemical synthesis approach, in silico modeling, and in vitro validation. The aim of this study is to comprehensively review the role of medicinal chemistry in the synthesis and development of selective anticancer compounds in breast cancer, with an emphasis on computational (in silico) approaches and experimental validation as two inseparable aspects of the modern drug discovery and development process. This study examined twenty articles related to natural and synthetic compounds tested for cancer targets such as HER-2, CDK4, and DAPK1. Compounds such as luteolin and benzimidazole derivatives show high affinity and cytotoxic activity in MCF-7 cells. The results show that the integration of computational and experimental approaches supports the development of breast cancer therapy that is more effective and safe.
Seminar Desa Sehat dan Digitalisasi: Pemanfaatan Tanaman Obat sebagai terapi Antihipertensi dan Penguatan Pemasaran Produk UMKM melalui NIB dan PIRT Mohammad Ikhsan Kurnia; Taufik Hidayat; Agis Difa Maharani; Tria Novita Siti Ramadhani; Ardina Malika; Dini Aryani; Asih Sri Sumantri; Wisnu Ramdani
Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Vol. 5 No. 3 (2026): September : Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia
Publisher : Sekolah Tinggi Ilmu Administrasi Yappi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jppmi.v5i3.2937

Abstract

A high prevalence of hypertension combined with limited understanding of business legality among micro-enterprise owners prompted this community service program in a rural village. Delivered through the Healthy and Digital Village Seminar, the program covered two areas: introducing Family Medicinal Plants (TOGA) as a supportive approach to managing hypertension, and strengthening MSME actors' grasp of business legality through the Business Identification Number (NIB) and the Home Industry Food Production Certificate (PIRT). Thirty residents took part, of whom 23 served as respondents in a pre-experimental One Group Pretest-Posttest evaluation. Given the non-normal distribution of scores, the Wilcoxon Signed-Rank Test was applied. Knowledge scores rose from 71.30 to 89.57 for the medicinal-plant material (p = 0.002) and from 66.52 to 90.87 for the NIB-PIRT material (p = 0.001), both changes reaching statistical significance. These findings suggest that pairing health education with business-legality guidance can yield combined benefits for rural communities and offers a model that could be adapted elsewhere.
Co-Authors Agis Difa Maharani Anggi Zulvana Asih Sri Sumantri Dini Aryani Hana Nurhanifah Mohammad Ikhsan Kurnia Nikeu Rahayu Saeful Amin Syamsiati Dwi Taufik Hidayat Tria Novita Siti Ramadhani Wisnu Ramdani