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All Journal Jurnal Ners Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Restu Anisa Putri
Universitas Muhammadiyah Riau
Health Professions Medicine & Pharmacology Nursing

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Faktor Gaya Hidup sebagai Prediktor Kualitas Hidup pada Pasien Luka Kaki Diabetik: Studi Cross-Sectional di Indonesia Restu Anisa Putri; Rani Sauriasari; Atika Wahyu Puspitasari
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53487

Abstract

Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus (DM) that significantly impacts patients' quality of life. Lifestyle factors, particularly smoking status and physical activity, are important modifiable factors to support improvement of this condition. This study aims to analyze the relationship between these two factors and the quality of life of DFU patients in Indonesia. A predictive cross-sectional study was conducted on 70 patients undergoing treatment at six branches of the Diabetic Wound Care Home Clinic in the Greater Jakarta area during March–May 2025. Quality of life was measured using the Indonesian version of the Diabetic Foot Ulcer Scale-Short Form (DFS-SF). Analysis was performed using the chi-square test for bivariate associations and multivariate logistic regression, controlling for confounding variables. The results showed that most patients did not smoke (74.3%) and did not exercise regularly (70.0%). Smoking status was significantly associated with quality of life (p=0.042), while physical activity showed a trend towards significance (p=0.060). Multivariate analysis identified physical activity as a predictor of quality of life (OR=5.30; 95% CI: 0.96–29.14; p=0.055), with patients who did not exercise being 5.3 times more likely to experience low quality of life. Smoking status showed a paradoxical result (OR=0.12; 95% CI: 0.02–0.82; p=0.030), which requires cautious interpretation. Physical activity also significantly impacted the domains of dependency/activities of daily living (p=0.001) and physical health (p=0.002). These findings emphasize the importance of integrating physical activity promotion and healthy lifestyle interventions in the holistic management of patients with LKD to support improved quality of life.
Association of Medication Adherence and VKORC1 Polymorphisms with Stable Warfarin Dose Requirements in Patients with Mechanical Heart Valves Syilvi Rinda Sari; Fendy Prasetyawan; Restu Anisa Putri
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.433

Abstract

Warfarin remains the primary oral anticoagulant for patients with mechanical heart valves, but considerable interindividual variability in stable dose requirements poses a clinical challenge. Although VKORC1 gene polymorphisms are well-established determinants of dose variability, the impact of objectively measured medication adherence is less clear. This study aimed to evaluate the independent and combined effects of VKORC1 polymorphisms and objectively measured medication adherence on stable warfarin dose requirements in patients with mechanical heart valves. Genotyping of VKORC1 −1639G>A (rs9923231) and 1173C>T (rs9934438) was performed using PCR–RFLP. Adherence over 90 days was expressed as the percentage of prescribed doses taken. The −1639A allele frequency was 81.7%, and patients with the AA genotype required significantly lower daily doses than GA or GG genotypes (p<0.001). Mean adherence was 89.4±11.2%. Multivariate regression showed that VKORC1 genotype, age, and adherence independently predicted stable dose,explaining 45.2% of variability. Stable warfarin dose was defined as an unchanged maintenance dose with a therapeutic INR (2.0–3.5) for ≥3 months.Adherence below 80% was associated with increased INR fluctuations and dose adjustments, highlighting adherence as a key clinical modifier alongside genetic factors.
Co-Authors Atika Wahyu Puspitasari Fendy Prasetyawan Rani Sauriasari Sari, Syilvi Rinda