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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Farmasi Indonesia
Mutmainnah, Alfira
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Pemberian Air Zamzam Setelah Latihan Fisik Terhadap Status Hidrasi Pemain Bulu Tangkis Fakultas Kedokteran Universitas Muslim Indonesia Mutmainnah, Alfira; Irwan, Andi Alamanda; Wello, Eny Arlini; Syamsu, Rahmat Faisal; Kartika, Irna Diyana
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 2 (2026): Volume 13 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i2.21521

Abstract

Bulu tangkis merupakan olahraga intensitas tinggi yang dapat menyebabkan kehilangan cairan tubuh, sehingga pemenuhan kebutuhan cairan sangat penting terutama setelah latihan. Air Zamzam diketahui memiliki kandungan mineral esensial dan pH basa yang lebih tinggi dibanding air mineral biasa, serta diduga dapat meningkatkan status hidrasi tubuh melalui stimulasi ekspresi aquaporin (AQP). Penelitian ini merupakan eksperimen nyata dengan metode kuantitatif komparatif. Sampel terdiri dari 8 mahasiswa (n=8) yang dibagi ke dalam dua kelompok: kelompok kontrol yang diberi air mineral biasa dan kelompok perlakuan yang diberi air Zamzam masing-masing 500 mL sebelum melakukan aktivitas fisik selama 30 menit. Status hidrasi dievaluasi berdasarkan parameter warna, berat jenis, pH, dan volume urin. Hasil menunjukkan bahwa seluruh subjek (100%) pada kedua kelompok tetap mengalami dehidrasi berdasarkan semua parameter tersebut. Analisis data menggunakan uji Mann-Whitney menunjukkan nilai p 0,05, yang berarti tidak terdapat perbedaan bermakna antara kedua kelompok, sehingga hipotesis alternatif ditolak. Dengan demikian, konsumsi air Zamzam setelah latihan fisik tidak memberikan pengaruh signifikan terhadap status hidrasi pada mahasiswa pemain bulu tangkis Fakultas Kedokteran Universitas Muslim Indonesia.
Cost-Effectiveness of Meropenem Versus Ceftriaxone for the Treatment of Sepsis at Dr. Tadjuddin Chalid Hospital Makassar Saud, Anshar; Mutmainnah, Alfira; Arifin, Bustanul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.909

Abstract

Sepsis is a critical condition arising from the body's response to an infection. In Indonesia, the incidence of sepsis remains notably high, with mortality rates reaching 49%. At Dr. Tadjuddin Chalid Hospital Makassar, meropenem and ceftriaxone are extensively utilized as empirical therapies. Conducting a cost-effectiveness analysis is essential for ensuring rational and efficient decision-making in the selection of appropriate antibiotic therapy. This study aimed to compare the cost-effectiveness of meropenem versus ceftriaxone in treating patients with sepsis in the inpatient ward of Dr. Tadjuddin Chalid Hospital Makassar. A retrospective cross-sectional design was employed, utilizing the medical records of patients with sepsis. Data were analyzed using the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER) to ascertain the economic value of both antibiotics. The results indicated that the ACER value of meropenem was IDR 731,180.68, which was lower than that of ceftriaxone (IDR 775,021.41), suggesting that meropenem was more cost-effective. The incremental cost of IDR 667,206 indicates the additional expenditure required for meropenem to achieve a 1% increase in the proportion of patients with a length of stay of less than 17.4 days. The sensitivity analysis results align with the ICER analysis, which identified meropenem as more cost-effective, enabling robust conclusions. Treatment costs emerge as the key variable affecting the ICER, requiring primary consideration when interpreting cost-effectiveness results. In conclusion, meropenem is more cost-effective than ceftriaxone and can be recommended as an alternative antibiotic therapy for patients with sepsis from a pharmacoeconomic perspective.
Co-Authors Anshar Saud Bustanul Arifin Irna Diyana Kartika Irwan, Andi Alamanda Syamsu, Rahmat Faisal Wello, Eny Arlini