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All Journal Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Barongko : Jurnal Ilmu Kesehatan
Meillisa Carlen Mainassy
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LITERATURE REVIEW OF EMBRYONIC DEVELOPMENT EPIGENETICS: CHROMATIN MODIFICATION AND CELL PROGRAMMING Kamila Alawiyah; Rizki Andini Nawawi; Meillisa Carlen Mainassy; Syarinta Adenina; Hamzah Alfarisi; Sternatami Liberitera
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 5 No. 6 (2025): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.18492220

Abstract

This study aims to comprehensively examine epigenetic mechanisms in embryonic development, focusing on the role of chromatin modification and cell programming as regulators of gene expression without changes in DNA sequence. The type of study used was qualitative , with a descriptive approach through literature review, which examined scientific literature from reputable international journals such as Nature, Trends in Genetics, and The FEBS Journal published between 2015 and 2025. Data were collected through systematic searches of scientific articles using thematic and inductive analysis techniques, including theme identification, data reduction, and concept categorization. The results of the study show that DNA methylation, acetylation, and histone methylation are key factors in regulating gene expression during the zygotic genome activation (ZGA) phase and the formation of cell lineages. This process demonstrates the complex interaction between epigenetic and transcriptional factors that determine the direction of cell differentiation. In addition, similarities in epigenetic regulation principles between mammals and plants were found, indicating the conservation of biological mechanisms across species. The implications of the study " " include the development of regenerative therapies, increased effectiveness of assisted reproductive technologies, and innovations in agricultural biotechnology. In conclusion, this study confirms that epigenetics is an important layer of regulation in developmental biology that enriches our understanding of the mechanisms of life formation from the earliest stages.
Karakterisasi Peran Bakteri Endofit Tanaman Herbal terhadap Aktivitas Antibakteri pada Mikroorganisme Patogen Manusia Eni Kurniati; Rahmat Pannyiwi; Meillisa Carlen Mainassy
Barongko: Jurnal Ilmu Kesehatan Vol. 4 No. 3 (2026): Barongko : Jurnal Ilmu Kesehatan (Juli)
Publisher : Asosiasi Guru dan Dosen Seluruh Indonesia

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Abstract

ABSTRACT Endophytic bacteria are microorganisms that live within plant tissues without causing damage to their host plants. These bacteria are known to produce various secondary metabolites that have potential as antibacterial agents. Herbal plants, as a source of bioactive compounds, also have the potential to serve as habitats for endophytic bacteria that produce antimicrobial compounds. This study aims to characterize endophytic bacteria from herbal plants and evaluate their antibacterial activity against human pathogenic microorganisms. The study used the method of isolating endophytic bacteria from herbal plant tissues, followed by antibacterial activity testing using the disc diffusion method against pathogenic bacteria such as Staphylococcus aureus and Escherichia coli. The results showed that several endophytic bacterial isolates were able to inhibit the growth of pathogenic bacteria with inhibition zones ranging from 10–18 mm. This indicates that endophytic bacteria from herbal plants have potential as a source of natural antibacterial compounds. Keywords: Endophytic Bacteria, Herbal Plants, Antibacterial, Pathogenic Microorganisms ABSTRAK Bakteri endofit merupakan mikroorganisme yang hidup di dalam jaringan tanaman tanpa menyebabkan kerusakan pada tanaman inangnya. Bakteri ini diketahui mampu menghasilkan berbagai metabolit sekunder yang memiliki potensi sebagai agen antibakteri. Tanaman herbal sebagai sumber senyawa bioaktif juga berpotensi menjadi habitat bagi bakteri endofit yang menghasilkan senyawa antimikroba. Penelitian ini bertujuan untuk mengkarakterisasi bakteri endofit dari tanaman herbal serta mengevaluasi aktivitas antibakterinya terhadap mikroorganisme patogen manusia. Penelitian menggunakan metode isolasi bakteri endofit dari jaringan tanaman herbal, diikuti dengan uji aktivitas antibakteri menggunakan metode difusi cakram terhadap bakteri patogen seperti Staphylococcus aureus dan Escherichia coli. Hasil penelitian menunjukkan bahwa beberapa isolat bakteri endofit mampu menghambat pertumbuhan bakteri patogen dengan zona hambat berkisar antara 10–18 mm. Hal ini menunjukkan bahwa bakteri endofit tanaman herbal memiliki potensi sebagai sumber senyawa antibakteri alami. Kata Kunci: Bakteri Endofit, Tanaman Herbal, Antibakteri, Mikroorganisme Patogen
Co-Authors Eni Kurniati Hamzah Alfarisi Kamila Alawiyah Rahmat Pannyiwi Rizki Andini Nawawi Sternatami Liberitera Syarinta Adenina