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All Journal Jurnal Kesehatan Cendikia Jenius
Binathara , Geraldus Sigap Gung
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Impact of Chemotherapy on Venous Thromboembolism in Cervical Cancer: Systematic Meta-Analysis Observational Studies Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Rajabto, Wulyo; Binathara , Geraldus Sigap Gung; Mayhana, Shuffa Chilla; Faqih, Fahrayhansyah Muhammad; Wirawan, Bintang; Putra, Abdul Hafiidh Surya
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 2 (2026): April 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i2.373

Abstract

Objective: Cervical cancer is associated with an increased risk of venous thromboembolism (VTE), which may be further aggravated by chemotherapy. This study aimed to assess the impact of chemotherapy on VTE incidence in patients with cervical cancer. Methods: A systematic review was conducted according to PRISMA 2020 guidelines. PubMed, the Cochrane Library, and EMBASE were searched from inception to October 2024 for observational studies reporting VTE incidence in cervical cancer patients receiving chemotherapy. Studies including women with cervical cancer treated with chemotherapy and reporting VTE outcomes were eligible, while studies evaluating radiotherapy or surgery alone were excluded. Results: Three observational studies involving 2,292 patients met the inclusion criteria. Pooled analysis showed that chemotherapy significantly increased VTE risk (RR 2.83; 95% CI: 2.05–3.90; p < 0.001), with low statistical heterogeneity. The reported incidence of chemotherapy-associated VTE ranged from 10.0% to 18.7%. Conclusion: Chemotherapy is associated with a nearly threefold increased risk of VTE in cervical cancer patients. These findings support routine VTE risk stratification prior to chemotherapy and consideration of individualized thromboprophylaxis. Further prospective studies are needed to define optimal prevention strategies.
Co-Authors Bintang Wirawan Faqih, Fahrayhansyah Muhammad Fitriyadi Kusuma Mayhana, Shuffa Chilla Putra, Abdul Hafiidh Surya Suryoadji, Kemal Akbar Wulyo Rajabto