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All Journal Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Indonesian Journal of Cancer Cermin Dunia Kedokteran
Putra, Abdul Hafiidh Surya
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Thrombositosis sebagai Prediktor Kanker pada Keganasan Ginekologi: a Narrative Review Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Abdullah, Muhammad Raoul Taufiq; Putra, Abdul Hafiidh Surya; Purwoto, Gatot; Winarto, Hariyono; Utami, Tofan Widya
Jurnal Ilmiah Kebidanan Indonesia Vol 13 No 02 (2023): Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Uni
Publisher : Q PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jiki.v13i02.2616

Abstract

Thrombositosis, peningkatan jumlah trombosit dalam darah, telah dikaitkan dengan kanker pada keganasan ginekologi. Trombositosis dapat dipicu oleh pelepasan sitokin oleh tumor ganas, seperti IL-6. Trombositosis berperan dalam perkembangan kanker melalui perlindungan terhadap sel tumor, produksi faktor pertumbuhan, dan angiogenesis. Tinjauan literatur ini mengumpulkan dan menganalisis penelitian terkait trombositosis sebagai prediktor kanker pada keganasan ginekologi. Pemahaman yang komprehensif tentang hubungan ini dapat membantu pengembangan metode deteksi dini dan terapi yang lebih efektif untuk kanker pada keganasan ginekologi.
Exploring the Molecular and Cellular Aspects of Hydatidiform Mole: a Narrative Review Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; As’syifa, Salsa Billa; Metasyah, Namira; Binathara, Geraldus Sigap Gung; Putra, Abdul Hafiidh Surya; Wulandari, Anisa Saphira
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1304

Abstract

Background: Hydatidiform mole, a type of gestational trophoblastic disease, arises from abnormal placental tissue and has the potential for malignant transformation. The condition’s incidence varies globally, with notable prevalence in Indonesia. Advanced maternal age, dietary factors, and a history of previous moles contribute to recurrence risks. Understanding the molecular and cellular mechanisms is critical for effective management.Methods: This narrative review synthesizes findings from primary studies and reviews exploring the molecular and cellular characteristics of hydatidiform mole. Data were sourced from Google Scholar, PubMed, and ScienceDirect using keywords like “hydatidiform mole,” “molecular mechanisms,” and “cell signaling pathways.”Results: The pathogenesis involves chromosomal abnormalities, particularly in complete moles characterized by a diploid genome lacking maternal DNA. P57KIP2 expression serves as a diagnostic marker, distinguishing complete from partial moles. Molecular genotyping, including short tandem repeat (STR) analysis, aids in accurate diagnosis and risk stratification for malignancy. Genetic factors, including mutations in NLRP7 and KHDC3L, are associated with recurrence in familial cases.Conclusion: The cellular and molecular insights into hydatidiform moles enhance understanding of their pathophysiology and inform diagnostic strategies. Recognizing genetic predispositions enables better patient management, emphasizing the need for continued research into the condition’s underlying mechanisms to improve clinical outcomes and therapeutic approaches.
Prognosis Mortalitas Pasien Tuberkulosis dengan Komorbid Diabetes Melitus Tipe 2: Analisis Suryoadji, Kemal Akbar; Fauzi, Ahmad; Ridwan, Alifaturrasyid Syafaatullah; Putra, Abdul Hafiidh Surya; Wisnu, Wismandari
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1248

Abstract

Introduction: Indonesia ranks 3rd in tuberculosis (TB) cases in the world, and data from the Ministry of Health in 2020 showed that 10%-15% of TB sufferers had diabetes mellitus (DM). TB is one of the important causes of death, and DM affects the immune system which can increase the severity and mortality of the disease. This evidence-based case report was conducted to examine the mortality risk of tuberculosis patients with DM comorbidity. Methods: An article search was conducted to answer research questions based on 3 databases: PubMed, Cochrane, and ScienceDirect with the keywords “((Tuberculosis) AND (DM type 2) AND (Mortality))”. The search was based on inclusion and exclusion criteria and a critical review was conducted according to the guidelines for prognostic studies. Result: Tuberculosis patients with type 2 DM comorbidities have a 1.51 times higher risk of mortality compared to tuberculosis patients without type 2 DM comorbidities. Conclusion: Study by Huangfu, et al, (2019) can be the best choice to answer the clinical question that the risk of death of tuberculosis patients with comorbid DM increases by 1.51 times compared to patients without DM.
Co-Authors Abdullah, Muhammad Raoul Taufiq As’syifa, Salsa Billa Binathara, Geraldus Sigap Gung Fauzi Ahmad Muda Fitriyadi Kusuma Gatot Purwoto Hariyono Winarto Metasyah, Namira Ridwan, Alifaturrasyid Syafaatullah Suryoadji, Kemal Akbar Utami, Tofan Widya Wismandari Wisnu Wulandari, Anisa Saphira