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All Journal Research of Scientia Naturalis Khazanah: Journal of Islamic Education and Science
Salim, Achmad Agus
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Agriculture, Biological Sciences & Forestry Chemistry Education Physics Other

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MICROBIAL CONSORTIA ENGINEERING: BRIDGING ENVIRONMENTAL MICROBIOLOGY AND SYNTHETIC BIOLOGY Salim, Achmad Agus; Wong, Lucas; Muller, Johannes
Research of Scientia Naturalis Vol. 3 No. 1 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v3i1.3342

Abstract

Natural ecosystems rely on complex microbial interactions that surpass the metabolic capabilities of isolated monocultures, yet engineering stable multi-species systems remains a significant challenge in biotechnology. This research addresses the unpredictability of interspecies social dynamics by integrating principles from environmental microbiology with the precision of synthetic biology. The study aims to evaluate a rational design framework for “obligate syntrophy” to maintain community stability and enhance metabolic throughput during the processing of complex feedstocks. Utilizing a “bottom-up” methodology, a synthetic consortium of Escherichia coli and Pseudomonas putida was engineered with cross-feeding circuits and quorum-sensing feedback loops for real-time population regulation. Results demonstrate that the engineered consortia achieved a stable co-existence for over 240 hours, representing a 45% increase in biomass yield and a 70% improvement in detoxification efficiency compared to non-engineered mixed cultures. Statistical analysis confirms that the division of metabolic labor significantly reduces individual cellular burden while increasing overall community resilience. This research concludes that bridging ecological wisdom with genetic circuit design provides a superior architecture for robust industrial bioprocessing. The findings offer a scalable blueprint for “programmable ecology,” asserting that engineered microbial consortia are essential for unlocking the full potential of the global circular bioeconomy.
Synergy of Environmental Theology and Green Technology in Developing a Sustainable Islamic Values Based Science Curriculum Salim, Achmad Agus; Nur Fitriyanti
Khazanah: Journal of Islamic Education and Science Vol. 1 No. 1 (2025): Khazanah: Journal of Islamic Education and Science
Publisher : Institut Bahri Asyiq Galis Bangkalan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61815/khazanah.v1i1.868

Abstract

The global ecological crisis and the rapid advancement of green technology have required the reconstruction of science curricula that are not only technologically oriented but also grounded in ethical and spiritual values. In the context of Islamic higher education, the integration of environmental theology and green technological innovation has not been systematically developed within curricular structures. This study aimed to analyze and formulate a conceptual framework for the synergy between environmental theology and green technology in developing a sustainable Islamic values based science curriculum. The research employed a descriptive qualitative approach using a meta-analytic method based on thematic synthesis of scientific literature published between 2016 and 2025, retrieved from the Scopus, Google Scholar, and Sinta databases. Data were collected through systematic digital documentation and analyzed using content analysis and thematic analysis. The findings indicated that the principles of tawhid, khalifah, amanah, and ecological balance functioned as epistemological foundations in framing the ethical application of green technology. A transdisciplinary curriculum model based on green technology projects was identified as the most promising approach for strengthening students’ sustainability competencies. This study contributed to the development of an integrative science curriculum model that bridges theological and technological dimensions in Islamic higher education.
MICROBIAL RESILIENCE UNDER ENVIRONMENTAL STRESS: A SYSTEMS-LEVEL ANALYSIS OF METABOLIC AND GENOMIC ADAPTATION Salim, Achmad Agus; Wei, Li; Johnson, Emily
Research of Scientia Naturalis Vol. 3 No. 2 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v3i2.3630

Abstract

Microbial resilience under environmental stress represents a fundamental aspect of biological survival, shaped by complex interactions between metabolic processes and genomic adaptation. Increasing environmental pressures such as temperature fluctuation, oxidative stress, and nutrient limitation challenge microbial stability, yet existing studies often examine metabolic and genetic responses in isolation. This study aims to develop a systems-level framework that integrates metabolic and genomic dimensions to explain how microorganisms sustain functionality under stress. The research employs a mixed-methods design combining laboratory-based multi-omics data, secondary datasets, and nonlinear computational modeling to analyze adaptive responses across temporal phases. Results indicate that microbial resilience is governed by coordinated mechanisms involving rapid metabolic reprogramming and subsequent genomic modification, with nonlinear dynamics such as threshold effects and multi-stable states shaping system behavior. Gene expression, metabolite flux, and mutation frequency exhibit strong interdependence, revealing feedback-driven adaptation rather than linear response patterns. The findings demonstrate that resilience emerges as a dynamic and context-sensitive process rather than a static trait. The study concludes that integrating ecological, metabolic, and genomic perspectives through nonlinear modeling significantly enhances the understanding of microbial adaptation and provides a robust analytical framework for future research and applied sciences.
Co-Authors Johannes Muller, Johannes Johnson, Emily Li Wei Nur Fitriyanti Wong, Lucas