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p-Index From 2021 - 2026
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All Journal Indonesian Journal of Pharmaceutical Science and Technology Journal of Bussines Management Basic
Putri, Liza Aulia
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Computer Science & IT Economics, Econometrics & Finance Medicine & Pharmacology Other

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Effects of Mesenchymal Stem Cell Secretome on Cardiac Histopathological Changes in Doxorubicin-Induced Rats Putri, Liza Aulia; Syahrizal, Dedy; Husna, Fauzul; Ridwan, Muhammad; Fitriyani, Sri
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69258

Abstract

Doxorubicin is an anthracycline chemotherapeutic agent widely used in clinical practice, but its application is limited by cardiotoxicity that damages myocardial structure and function. Mesenchymal stem cell secretome contains diverse bioactive molecules, including cytokines, growth factors, and extracellular vesicles, which contribute to tissue protection and cellular repair. This study aimed to evaluate the preventive and curative effects of secretome administration on histopathological changes in the hearts of doxorubicin-induced rats. Twenty-four rats were divided into four groups: without treatment (KS), cardiotoxicity group (KK), preventive secretome (P1), and curative secretome (P2). Histopathological assessment included degeneration, inflammatory infiltration, congestion, and necrosis using semi-quantitative scoring. Results showed no significant differences in degeneration, inflammatory infiltration, or congestion among groups. In contrast, necrosis scores differed significantly (p = 0.002), with the highest values observed in the KK group. Secretome administration in the P2 group demonstrated the most pronounced improvement, reflected by a greater reduction in necrosis scores compared to other groups. In conclusion, curative-phase secretome treatment provided the most effective histological improvement by reducing myocardial necrosis, indicating a stronger tissue repair response than preventive administration.
Product Innovation Analysis at Nyai Cipelah Chips MSME Sumiati, Ai; Nurmayanti, Ade Rima; Anwar, Muhammad Kaisar; Putri, Liza Aulia; Komala, Rini Noerfiany
Journal of Bussines Management Basic Vol 8 No 1 (2026): Journal of bussines management
Publisher : Universitas Sebelas April, Fakultas Ekonomi dan Bisnis

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Abstract

Nyai Cipelah Chips is a local small business that demonstrates how basic ingenuity and innovation can fuel growth, even with minimum funding. Founded in 2023 and called after the owner's nickname, "Nyai," and her village name, "Cipelah," the firm started as a simple fried food kiosk with capital of just IDR 500,000. The company has developed into a manufacturer of a variety of chip items that are marketed online, at MSME centers, local markets, and gift stores. Observations and interviews with the owner show that product innovation has played a crucial part in this development. The business experiments with diverse raw materials, introduces new and modern flavors, and continuously expands its product rangeThese efforts, combined with a strong focus on consistent quality, help the chips stand out in the local market. A noteworthy advance is the variety of ingredients. By employing multiple tubers and alternative materials, the business offers additional alternatives to consumers while lowering the danger of raw material shortages. Popular flavors such as numerous hot levels, balado, and savory spice blends also improve the product’s appeal. With five workers and a daily output of roughly five balls of chips, production is tiny but tightly maintained. Every stage is regulated to guarantee steady taste and texture, which builds consumer loyalty. bigger audiences without expensive promotional costs. Challenges exist, including variable raw material supply and escalating pricing. The owner must regularly alter sourcing and price tactics while competing with other local chip producers. To be competitive, the firm focuses on flavor uniqueness and quality enhancement. Overall, product innovation has considerably enhanced the expansion of Keripik Nyai Cipelah. With its focus to quality, inventive flavors, and adaptable marketing, the business is well-positioned to continue growing as a strong local brand.
Co-Authors Anwar, Muhammad Kaisar Dedy Syahrizal Husna, Fauzul Komala, Rini Noerfiany Muhammad Ridwan Nurmayanti, Ade Rima Sri Fitriyani Sumiati, Ai