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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence African Journal of Biochemistry and Molecular Biology Research African Journal of Sciences and Traditional Medicine Kwaghe International Journal of Sciences and Technology African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Samuel Tamunoiyowuna Cockeye Brown
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Antimicrobial Activity of Senna siamea Fresh Leaf Extracts (Ethanolic and Aqueous Solution) on Shigella Species and Pseudomonas aeruginosa Samuel Tamunoiyowuna Cockeye Brown; Usman Ikrimah Mohammed; Eze Emmanuel Onyemaechi; Shinggu Paula Paul
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 3 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i3.7038

Abstract

The rising threat of antibiotic-resistant bacteria has intensified the search for alternative antimicrobial agents, particularly those derived from plants. Numerous plant species have long been used in traditional medicine, with leaf extracts showing promising antimicrobial potential. This study investigates the antimicrobial activity of ethanol and aqueous leaf extracts of Senna siamea against Shigella spp. and Pseudomonas aeruginosa. Fresh leaves of S. siamea were collected, authenticated, and subjected to solvent extraction using ethanol and distilled water. The antimicrobial effects of the extracts were evaluated using the agar well diffusion method, while the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined through standard microbiological procedures. The ethanol extract exhibited marked inhibitory effects against P. aeruginosa at all tested concentrations, whereas the aqueous extract showed greater efficacy against Shigella spp. at 100% concentration. Both extracts demonstrated bactericidal properties at a concentration of 1 mg/mL. These findings indicate that S. siamea contains bioactive compounds with significant antimicrobial activity, affirming its traditional use in treating infectious diseases. The results support the potential of S. siamea as a natural alternative for managing bacterial infections, particularly those involving resistant strains. Further research involving phytochemical profiling, toxicological analysis, and clinical evaluation is recommended to isolate the active compounds and assess their pharmaceutical applications.
Co-Authors Benjamin Nanisi Daniel Danya Sunday Emmanuel Onyemaechi Eze Emmanuel Onyemaechi Habiba Idris Adam Ibrahim Jamilat Mijinyawa Ikrimah Usman Mohammed Isaac John Umaru Nurudeen Umar Abdulkadir Odey Catharine Rita Shinggu Paula Paul Shuaibu Adamu Ladan Tanko Saadatu Yahaya Timothy Nehemiah Ugwuala Chimaobi Melvin Usman Ikrimah Mohammed Yusuf Precious Wama