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All Journal African Journal of Biochemistry and Molecular Biology Research Kwaghe International Journal of Sciences and Technology
Maianguwa Abdulrsashid Dauda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Law, Crime, Criminology & Criminal Justice Social Sciences

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Determination of Mineral, Vitamin Content and Antioxidant Activity of Telfairia Occidentalis Seed Abdulmumin Jabir; Ahmad Alhassan Siddan; Maianguwa Abdulrsashid Dauda; Isaac John Umaru; Bilyaminu Habibu; Adeseye Helen Oluwabunmi; Kingsley Iyoko Iseko; Dafup Katdel Istifanus
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3665

Abstract

Telfairia occidentalis, also known as fluted pumpkin, is a widely cultivated vegetable in West Africa with potential nutritional and health benefits. They serve to supplement the nutrients provided by cereals and tubers; however, there is lack of comprehensive compositional data regarding the mineral of fluted pumpkin seeds in Nigeria. This study aimed to determine the mineral, vitamin, and antioxidant properties of T. occidentalis seeds. The seeds were analyzed for their mineral content (calcium, iron, zinc, magnesium, potassium, and sodium), vitamin content (vitamins A, C, and E), and antioxidant activity using standard analytical methods. The results showed that the seeds were rich in essential minerals, especially manganese; 573.01±0.39mg/kg, sodium; 525.02±0.91mg/kg, calcium; 297.06±1.05mg/kg, iron; 53.42±0.59mg/kg and zinc; 5.65±0.01mg/kg. The seeds exhibited potent antioxidant activity, as measured by various in vitro assays. The presence of vitamin E (35.54±0.47mg/kg), vitamin C (20.20±0.44mg/kg) and vitamin A (15.17±0.16mg/kg). The low levels of antioxidant activity ferric reducing antioxidant power (0.49±0.01) and hydrogen scavenging activity (1.20±0.01) makes the fluted pumpkin (Telfairia occidentalis) safe for consumption. These findings suggest that T. occidentalis seeds could be a valuable source of nutrients and bioactive compounds with potential health-promoting properties. Further research is warranted to explore the nutritional and therapeutic applications of this underutilized seed crop.
Phytochemicals Screening, Minerals Composition and Proximate Analysis of Garlic (Allium sativum) Maianguwa Abdulrsashid Dauda; Sulaiman Abubakar Aliyu; Lazaru Joseph Goje; Bilyaminu Habibu; Emmanuel Askeb-nde Joel; Isaac John Umaru; Kingsley Iyoko Iseko; Dafup Katdel Istifanus
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3666

Abstract

Garlic (Allium sativum) is a widely used medicinal plant with potential health benefits. The use of medicinal plants as remedies or medicine in prevention and treatment of several diseases was in place for many years. Garlic (Allium sativum) is among those plants because it possesses those characteristics. In this study, we investigated the phytochemical constituents, mineral composition, and proximate analysis of garlic. The qualitative phytochemicals screening of garlic ethanolic extract reveals the presence of Tannins, Alkaloid, Saponin, steroid, Glycosides, phenols and flavonoid while the quantitative shows that the extract composed of Alkaloid 10%, Saponin 5.30%, Tannin 4.10 µg/ml, Glycosides 4.40%, flavonoid 2.20%, phenols 3.14 µg/ml. The proximate analysis reveals that the garlic extract contains carbohydrate 65.84%, fiber 7.14%, fat 2.15%,ash 9.90%,moisture 7.58%, protein 7.30% The determination of some minerals composition in (mg/kg) reveals that the extract is composed of sodium(22mg/kg), potassium(531.5 mg/kg), zinc(7.1 mg/kg), copper(0.36 mg/kg), Iron(2.7 mg/kg), calcium(233 mg/kg) and magnesium(35.4 mg/kg) respectively were also detected, highlighting garlic's potential as a nutraceutical food supplement.. This research contributes valuable insights into the bioactive components of garlic, supporting its traditional use and potential health benefits. Further studies could explore its antioxidant, antimicrobial, and therapeutic properties.
Ferroptosis and Cancer Therapy Review James Agbu Sunday; Otitujo Olawale; Isaac John Umaru; Maianguwa Abdulrsashid Dauda
Kwaghe International Journal of Sciences and Technology Vol 1 No 1 (2024): Kwaghe International Journal of Sciences and Technology
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/kijst.v1i1.3687

Abstract

Ferroptosis is a type of intracellular iron-dependent cell death that is different from autophagy, necrosis, and apoptosis. Ferroptosis is necessary for tumour suppression, according to a number of studies, which opens up new therapy options for cancer. The establishment of resistance to cancer therapy is one of the most significant ongoing challenges. The subject of conquering drug resistance has been the focus of numerous preclinical and clinical studies. Interestingly, ferroptosis has been associated with treatment resistance for cancer, and ferroptosis stimulation has been demonstrated to reverse drug resistance. The current knowledge of ferroptosis-inducing and ferroptosis defence mechanisms analyses the functions and mechanisms of ferroptosis in tumour immunity and tumour suppression, conceptualises the various ways that cancer cells are vulnerable to ferroptosis, and investigates therapeutic approaches for ferroptosis targeting in cancer. Cancer is one of the most terrible illnesses that can kill a person worldwide. There are several ways to treat cancer, including surgery, chemotherapy, and radiation. Analysis of the sensitivity of cancer cells to ferroptosis, which is impacted by their elevated reactive oxygen species levels and particular mutation profiles, opens up new possibilities for improving the efficacy of already used cancer treatments. This review included the state of knowledge about the induction and defence mechanisms of ferroptosis, the function and mechanisms of ferroptosis in tumor suppression, and treatment approaches for tumor-induced ferroptosis.
Co-Authors Abdulmumin Jabir Adeseye Helen Oluwabunmi Ahmad Alhassan Siddan Bilyaminu Habibu Dafup Katdel Istifanus Emmanuel Askeb-nde Joel Isaac John Umaru James Agbu Sunday Kingsley Iyoko Iseko Lazaru Joseph Goje Otitujo Olawale Sulaiman Abubakar Aliyu