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All Journal African Journal of Sciences and Traditional Medicine
Ananias Amen
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Chemistry Health Professions Immunology & microbiology Nursing Public Health

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Effects of Brassica oleraceae Leaves on Serum Liver Function of Wistar Rats Intoxicated with Prednisolone Ananias Amen; Dawoye Yusufu; Gloria Omonefe Oladele; Kerenhappuch Isaac Umaru
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3692

Abstract

The recent study investigated the effects of ethanol extract of Brassica oleracaeae leaves on prednisolone induced toxicity in male albino rats. Liver markers were assayed in order to investigate the toxic effect of prednisolone and the ameliorating effects of the extract. Sixteen (16) rats grouped in to four (n=4) were administered prednisolone and ethanol leaves extract based on the experimental design. The male albino rats were sacrificed after the experimental period of fourteen (14) days, blood was collected for assay of the liver function by ocular puncture. Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) levels were significantly (p<0.05) increased from 5.67 ± 5.13 and 6.67 ±7.02 to 26.67 ± 8.02 and 25.00 ± 4.00 respectively when rats where administered with prednisolone toxicity. Upon treatment of rats with ethanol leaves extract of B. oleraceae at 100mg/kg, the concentration of AST and ALT were lowered to 7.67 ± 6.81 and 8.00 ± 7.55 respectively. A further increased in the concentration of the extract to 300mg/kg resulted to a significant (p<0.05) increased of AST (9.33 ± 8.12) and ALT (12.00 ± 10.00) levels. Similarly, the levels of alkaline phosphatase (ALP) and Albumin increases in the group that were administered with prednisolone however, when rats were treated with ethanol leaves extract of Brassica oleracaeae such concentrations were decreased. The findings of this study can be concluded that, the ethanol leaves extract of Brassica oleracaeae showed capacity in ameliorating the effects induced by prednisolone intoxication.
Effects of AlCl3 on the Enzymatic Antioxidants of Wister Rats Treated with Moringa oleifera Seed Extracts Dawoye Yusufu; Simon Teza Zinas; Bilyaminu Habibu; Ananias Amen; Isaac John Umaru; Yakubu Ojochenemi Ejeh; Onwubiko N. Grace; Onwubiko A. Henry; Anthony Mishara Audu; Kerenhappuch Isaac Umaru
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3693

Abstract

Determination of Malondialdehyde, MDA in blood plasma or tissue homogenates is one of the useful methods to predict the oxidative stress levels. The current study investigates the ameliorative effects of the seed extracts of Moringa oleifera on 35 albino rats induced with AlCl3 toxicity. Biomarkers of oxidative stress (Superoxide Dismutase, SOD; Catalase, CAT; Glutathione Peroxidase, GPx and Malondialdehyde, MDA were assayed. The plant seed extracts were shown to reduce the levels of MDA increased by AlCl3. AlCl3 caused decrease in (glutathione peroxidase) GPx levels as it causes MDA to significantly get elevated. The results showed that GPx decreased from 9.48 ± 0.86 to 6.68 ± 1.73 but upon treatments with 100 mg/kg bw of M. oleifera, GPx levels increased to 8.84 ± 0.86 (ethanol) and 8.96 ± 0.86 (aqueous). Increasing the concentrations of the extracts further increased the GPx levels while MDA were reduced.
Co-Authors Anthony Mishara Audu Bilyaminu Habibu Dawoye Yusufu Gloria Omonefe Oladele Isaac John Umaru Kerenhappuch Isaac Umaru Onwubiko A. Henry Onwubiko N. Grace Simon Teza Zinas Yakubu Ojochenemi Ejeh