Article Per Year (5 Year)
p-Index From 2021 - 2026
3.277
P-Index
This Author published in this journals
All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence African Journal of Biochemistry and Molecular Biology Research African Journal of Sciences and Traditional Medicine Kwaghe International Journal of Sciences and Technology African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Kerenhappuch Isaac Umaru
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Evaluation of Potential in Wonderful Kola (Buchiolizia coreica) Seed Extract on Streptozotocin Induced Type 2 Diabetes in Male Wister Rats Isaac John Umaru; Nwachukwu Favour Onyinyechi; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze; Nanyak Zingfa Galam
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3388

Abstract

Diabetes mellitus is referred to as a metabolic disorder in which there is high glucose level in the blood as a result of insulin deficiency, resistance or both. Globally, it has been deducted that the adult population with diabetes will rise by 69% for the year 2030. Thus, Bucholzia Coriacea (B. Coriacea) a perennial plant belonging to the family capparidaceae and genus Bucholzia is popularly known as wonderful kola. It’s also known as wonderful kola, its other name is called Garcinia kola .it has a long history of use in west Africa and central Africa, thus, the study on evaluation of potential in wonderful kola (buchiolizia coreica) seed extract on streptozotocin induced type 2 diabetes in male wister rats. Material and Methods: Fresh seeds of B. coriacea were plucked and washed with distilled water, the filtrate was concentrated using rotary evaporator and water bath. The extract was then weighed and stored in a refrigerator. 100g of crude extract and 1000mg of metformin was properly dissolved in 10ml of distilled water. The rats were carefully selected and separated into cages. 7 albino rats were used for normal control while 4 rats were kept in each of the remaining cages, and 6 replications were obtained, the test was carried out carefully by injecting the alloxan into the rats intraperitoneally and infecting them with diabetes mellitus, the following sets were made: normal group, negative and positive control group, while three groups were for extracts dosage. With exception of the normal control, all the groups were induced with diabetes. The extract (stem bark of Mangifera indica) will be administered orally to the three set of groups separately (i.e., one extract to one set). Determination of Fasting Blood Glucose Level by Intestinal Glucose Absorption. Results: Treatment groups receiving methanol Wonder Kola seed extract showed varying degrees of improvement in these parameters compared to the negative control group. Notably, Group VI, receiving the highest dose of the extract, demonstrated the most significant reduction in urea levels, suggesting a potential protective effect on renal function. The study investigated the effects of Wonder Kola seed extract on serum electrolytes, urea, and creatinine levels in alloxan-induced diabetic albino rats. Notably, significant variations were observed in these biochemical parameters across the different treatment groups. The study assessed the effects of methanol Wonder Kola seed extract on liver enzymes (AST, ALT, ALP) and serum protein levels (total protein, albumin, total bilirubin, direct bilirubin). Significant variations were observed in these parameters among the treatment groups compared to the normal and negative control groups. Treatment with the extract led to notable reductions in liver enzyme levels, indicating potential hepatoprotective effects. Conclusion: The findings of this study demonstrate the potential pharmacological benefits of methanol Wonder Kola seed extract in managing diabetes mellitus and associated complications.
Evaluation of Antibacterial Activity and Toxicity Effects of Newbouldia Stem Bark Extract Kerenhappuch Isaac Umaru; Isaac John Umaru; Akafa Andes Tansaba; Chakfa Nanmar; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3350

Abstract

Newbouldia leavis is a boundary tree. it is a medium size angiosperm which belongs to the Bignoniaceae family. It is a fast-growing evergreen shrub or small tree. This study was carried out to investigate antibacterial activity of the methanol extract of Newbouldia stem bark. The antibacterial activity of the methanol extracts was determined by the agar well diffusion method. Three standard bacterial strains: Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae were used for the antibacterial assay. Result of screening plant extracts for antibacterial activity showed that most of the organisms were sensitive to the extract. The antibacterial test utilizing well diffusion assay showed that Gram-positive bacteria were more susceptible to the plant extract compared to Gram-negative bacteria. This study supports the use of Newboulda leavis in traditional medicine as well as highlights the need to further explore the potentials of the plant extract as antibacterial agent.
Hypoglycemic Potentials of Newbouldia laevis Stem Bark Extract in Alloxan-Induced Diabetic Rats Isaac John Umaru; Gabriel Favour Chisom; Kerenhappuch Isaac Umaru; Akafa Andes Tansaba; Chakfa Nanmar; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3351

Abstract

This study was carried out to investigate the antidiabetic of the methanol extract of Newbouldia stem bark and to determine its safety and toxicity. Alloxan (150 mg/kg) was administered to albino rats via the oral route. The diabetic rats were then placed in 6 groups, following stabilization of hyperglycemia. The first group was non-diabetic, the second and third group were the diabetic control. The next three groups received, each day, 100, 200 and 400 mg/kg body weight of the methanol extract Newbouldia laevis and the second group received a reference standard, metformin (200mg/kg). Treatment was via the oral route for 14 days and fasting blood sugar level was monitored over this period. Acute toxicity (oral and intraperitoneal) studies on the extract was carried out. Blood glucose levels from day 1 to 14 days of treatment increased significantly (p <0.05) in all the treatment groups, except group 3 (positive control) which showed no significant difference compared to the normal control group. This study supports the use of Newbouldia laevis in traditional medicine as well as highlights the need to further explore the potentials of the plant extract as an antidiabetic.
Antibacterial and Antioxidant Capacity of Methanol Root Extract of Mangifera Indica Isaac John Umaru; Sule John Ugbedeojo; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3352

Abstract

Recent years have witnessed enhanced research work reported on plants and plant products. In this regard, plants with traditional therapeutic usage are being screened more efficiently to be considered as a substitution or as a better alternative agent for Human Pathogens. Antioxidant activity, antibacterial, antifungal properties, colour, phytochemical and FT-IR spectral analysis of flowers belonging to Hibiscus moscheutos was determined. Radical scavenging activity of sample extracts were determined based on the percent inhibition of DPPH and ferric reducing antioxidant power (FRAP) assays. Total phenolics were estimated based on the Folin–Ciocalteu method, while, vanillin–HCl and aluminum chloride methods were employed to estimate total tannins and flavonoids in the sample extracts, respectively. To determine total flavonols and anthocyanin contents, spectrophotometric method was employed. For antibacterial activities, modified agar disk diffusion method was adopted. Results: The crude extracts of hexane, dichloromethane, chloroform, ethyl acetate and methanol, extracts with concentration levels at 100, 200, 300 and 400 mg/mL were shown to significantly affect the inhibition of bacterial selected. The presence of phytochemicals compounds possesses the high antibacterial activities of this crude extracts. This study proved that Mangifera Indica crude extracts could be useful for inhibiting the selected pathogens which has an antioxidant potential as well as a natural bacterial agent.
Hepatocurative Effect of Methanol Extract of Newbouldia laevis Leaves in Alloxan-Induced Liver Damage in Albino Rats Isaac John Umaru; Tsokwa Punarimam Rebecca; Akafa Andes Tansaba; Chakfa Nanmar; Kerenhappuch Isaac Umaru; Egeonu Stephen Ugoeze; Tyem Lawal Danjuma
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3354

Abstract

The aim of the study is to evaluate the effect (Hepatocurative and antibacterial potential) of Newboulda laevis leaves in alloxan-induced liver damage in Wister Albino Rats. The leaves of Newbouldia laevis was bought from a local market in Wukari, Taraba State. The leaves of Newbouldia laevis was chop and then pulverized into fine powder. The methanol crude extracts andthirty-two albino Wistar rats weighing 90-220 g was used for this research. Liver toxicity was induced in male rats by an intraperitoneal single dose of 150 mg/kg body weight. samples were subjected to biochemical estimation of liver function. The result showed a significant (p≤0.05) increase in serum AST level for group II (60.6 ± 1.12) which was administered high dose of Alloxan and serves as the negative control group, when compared to the normal control group I (35.09 ± 2.07) which only received feed and water. From the result described in table 4.0 above, it showed a significant (p≤0.05) increase in ALT level for group II (58.11 ± 0.42) negative control when compared with group I (20.00 ± 0.41) normal control. Group III (29.98 ± 0.12) which received standard drug showed a significant decrease in ALT which is a sign that there is some level of repair on the liver cells. Group IV (36.22 ± 0.s70), group V (30.00 ± 0.27) and group VI (29.99 ± 0.12) which received 100, 200 and 400 mg/kg body weight of Newbouldia laevis leaves extract respectively when compared with the negative control group II, showed a significant decrease in ALT level. There was a significant (p≤0.05) increase in ALP level for group II (255.80 ± 1.12) which received Alloxan when compared with the normal control group I (80.21 ± 0.44) providing evidence to support the increase in ALT and AST level in group II, suggestive of liver injury. The treatment groups III, VI, V and VI showed significant (p<0.05) difference, when compared to the negative control group. No significant (p<0.05) difference between group V and VII. It was deduced that the total protein for group II (10.95 ± 0.37) significantly (p<0.05) decreased when compared to the normal control group I (14.13 ± 0.55). This is because low levels of total protein in the blood can occur because of impaired function of the liver. Administration of Newbouldia laevis leaves extract significantly (p<0.05) elevated total protein levels for group IV (10.99 ± 0.41), V (12.76 ± 0.41) and VI (12.98 ± 0.58). Albumin being the most abundant protein in the blood, equally followed same pattern as total protein, with Albumin level of (10.83 ± 0.10), (6.13 ± 0.05), (9.82 ± 0.18) (6.75 ± 0.13), (7.99 ± 0.10) and (9.60 ± 0.13) for group I, II, III, IV, V and V respectively. Thus, emphasizing the potential of the extract as a source agent for medication for ailment and diseases.
Review: The Biochemistry of Love and Loving Nwachukwu Favour Onyinyechi; Ikwebe Joseph; Kerenhappuch Isaac Umaru; Isaac John Umaru
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3355

Abstract

Human love is more complex than simple feedback mechanisms. Love create its own reality. The biology of love originates in primitive parts of the brain; the emotional core the human nervous system, that evolved long before the cerebral cortex. The brain of human ‘in love’ is flooded with sensations, often transmitted by the vagus nerve, creating much of what we experience as emotion. The modern cortex struggles to interpret the primal messages of love, and weaves a narrative around incoming visceral experiences, potentially reacting to that narrative rather than reality. The four functions of love include; Romantic love (erotic) love, Friendly love or Platonic love (Philia), Familial love (Storge) and Unconditional love (Agape). Glutamate is an excitatory neurotransmitter released by the nerve cell. It’s mostly referred to as the master switch of the brain. Lust: Characterized by a strong desire for sexual gratification and is primarily driven by testosterone and oestrogen. Attraction: This stage involves intense romantic and sexual feelings, associated with dopamine, norepinephrine, and serotonin. Attachment: The final stage, involving long-term commitment and bonding, is influenced by oxytocin and vasopressin. The hypothalamus of the brain plays a big role in stimulating the production of sex hormones testosterones and oestrogen from the testes and ovaries. These chemicals are often stereotyped as being ‘male’ and ‘female’ respectively, both plays a role in men and women. Males produce forty to sixty times more of the testosterones. Testosterones increases the libido in male and female. The effect is less pronounced with oestrogen, but some woman report being more sexually motivated around the time the ovulate, when oestrogen levels are highest. Conclusions: Love is a complex neurobiological phenomenon, relying on trust and belief as well as brain reward activity.
Review: Neurochemical Aspects of Mental Health and Neurological Diseases Isaac John Umaru; Nwofor Innocent; Kerenhappuch Isaac Umaru
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3473

Abstract

Neurochemistry is the study of chemicals, including neurotransmitters, hormones, and other molecules, that influence the function and behavior of the nervous system. This field has evolved significantly since the early 20th century, driven by key discoveries and technological advancements such as Neurotransmitters and Mental Health, "Neurotransmitters like serotonin, dopamine, and norepinephrine are fundamental in regulating mood, cognition, and behavior. Disruptions in these systems are implicated in various psychiatric disorders". Also, Neurotransmitter Imbalances and Mental Disorders: this is the Alterations in neurotransmitter levels, such as serotonin and dopamine, are associated with the symptoms of depression and schizophrenia". Then the GABAergic dysfunction is linked to anxiety disorders, highlighting the role of inhibitory neurotransmission in mental health". As well as Role of Neurochemicals in Specific Disorders: where low serotonin levels are commonly found in individuals with depression, leading to the development of SSRIs as a treatment". The review also look into Schizophrenia which is associated with both hyperactivity and hypoactivity of dopamine pathways, which influences treatment strategies", as well as the Neurochemical Pathways and Mechanisms: The HPA axis plays a critical role in the stress response, and its dysregulation which is linked to mood disorders". Dopaminergic pathways, including the mesolimbic and nigrostriatal systems, are essential for reward and motor control" as well as the Neurotransmitter Receptors and Transporters, Serotonin receptors, such as 5-HT1A, are critical in mood regulation and are targeted by many antidepressants". The central point of disorder "Dopamine transporters are involved in the re-uptake of dopamine and are implicated in disorders like ADHD and addiction". Thus, Neuroinflammation and Mental Health: which Increased neuroinflammation is associated with depression, with elevated pro-inflammatory cytokines observed in affected individuals", "Microglia and their role in neuroinflammation and psychiatric disorders are all the key area of the research."
Exploring the Links between Genetics and Diseases: Review Isaac John Umaru; Chabunda Endashi Esseyi; Kerenhappuch Isaac Umaru; Akafa Andes Tensaba; Dafup Kadel Istifanus; David Umahi
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3482

Abstract

This review article delves into the intricate connections between genetics and diseases, exploring how genetic variations influence the development and progression of various health conditions. The paper provides a comprehensive overview of the latest research in the field of genomics, highlighting key discoveries that have advanced our understanding of the genetic underpinnings of diseases. We examine both monogenic and polygenic disorders, illustrating how mutations in single genes or complex interactions among multiple genes contribute to disease phenotypes. Furthermore, the review discusses the role of epigenetics and gene-environment interactions in modulating disease risk and expression. By synthesizing current findings, this article underscores the potential of genetic research in paving the way for personalized medicine and targeted therapies, offering new avenues for diagnosis, treatment, and prevention of genetic diseases. The review also addresses the ethical and societal implications of genetic research, emphasizing the importance of responsible scientific practices and equitable access to genetic advancements.
Review: Functions and Mechanism of Biochemical Markers in The Monitoring of Covid-19 Patients Isaac John Umaru; Kaka Garpiya Yakubu; Kerenhappuch Isaac Umaru
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3485

Abstract

COVID-19 is an infectious disease caused by the SARSCoV-2 virus, which has given rise to a global sanitary emergency. The clinical characteristics of COVID-19 are varied and can range from an asymptomatic infection to a mild to severe pneumonia. Recent studies have shown that different laboratory parameters become altered in these patients, and as such are useful as biomarkers to assess the progression of the disease and categorize patients that may present a severe and/or fatal clinical condition. This review analyzes biochemical and immunological markers that become altered in COVID-19 patients and their impact on different organs at a hepatic, cardiac, renal and pancreatic level, as well as markers of inflammation, analyzing their implications in the evolution of the disease.
Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer Isaac John Umaru; Otitoju Olawale; Emmanuel Chikodiri Okoli; Akafa Andes Tensaba; Kerenhappuch Isaac Umaru; Dafup Kadel Istifanus; David Umahi
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3487

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.
Co-Authors Akafa Andes Tansaba Akafa Andes Tensaba Ananias Amen Anthony Mishara Audu Artu Ishishen John Bilyaminu Habibu Chabunda Endashi Esseyi Chakfa Nanmar Dafup Kadel Istifanus Daniel Konka David Umahi Dawoye Yusufu Edom Favour Ogochukwu Egeonu Stephen Ugoeze Emmanuel Chikodiri Okoli Gabriel Favour Chisom Gloria Omonefe Oladele Ikwebe Joseph Isaac John Umaru Iseko Iyoko Kingsly Jackson Soyinka Malantso Jibaniya Grace Mchibuma Joseph Oteng Julius Ishaya Salman Kaka Garpiya Yakubu Katchim Evelyn Shadrach Manasseh Ilumunter Matilda Muhammad Akram Nanyak Zingfa Galam Nkiri Annasthesia Ekubnse Nwachukwu Favour Onyinyechi Nwofor Innocent Ocheifa Matthew Ngbede Okrah George Hassan Onwubiko A. Henry Onwubiko N. Grace Otitoju Olawale Prince Kwadwo Gyasi Simon Teza Zinas Solomon Godiya Marvelous Solomon Ossom Asare Sule John Ugbedeojo Tensaba Andes Akafa Tsokwa Punarimam Rebecca Tyem Lawal Danjuma Ugwuoke Kenneth C Yakubu Ojochenemi Ejeh Zephaniah Hananiah Shenia