Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal African Journal of Sciences and Traditional Medicine
Agbo Chibuike Ekunyi
Unknown Affiliation
Chemistry Health Professions Immunology & microbiology Nursing Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effects of Methanol Stem Bark Extract of Annona senegalensis on Kidney Function and Lipid Profile in Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Rats Isaac John Umaru; Khalid Yahuza Abbas; Mosugu Ovayoza Omolara; Agbo Chibuike Ekunyi; Usman Ikira; Ogar Fonne Okang; Ingwu Joseph Akem; Akafa Andes Tansaba; Otashu Kenneth Frank; Shadrach Philip
African Journal of Sciences and Traditional Medicine Vol 2 No 3 (2025): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v2i3.7358

Abstract

Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, with high morbidity and mortality. This study evaluated the anticancer properties of Annona senegalensis stem bark extract in N-diethylnitrosamine (DEN)-induced hepatocellular carcinoma in Wistar rats. Liver carcinogenesis was induced in groups II–VI by intraperitoneal injection of DEN (50 mg/kg body weight in DMSO) once weekly for three weeks. Group II served as the negative control, while group III was the positive control (treated with silymarin, 100 mg/kg b.w.). Groups IV, V, and VI received ethanol extracts of A. senegalensis at 200, 400, and 600 mg/kg b.w., respectively, administered orally for 14 days. Treatment with the extract significantly (p < 0.05) reduced blood urea and creatinine levels, improved electrolyte balance, and enhanced liver histoarchitecture. The extract also favorably modulated lipid metabolism, lowering cholesterol levels from 368.57 ± 1.72 in the negative control to 251.31 ± 1.10 at 400 mg/kg, while increasing HDL levels from 96.21 ± 1.23 to 233.13 ± 0.86 at 600 mg/kg. These results suggest a cardioprotective role via improved lipid profiles. Additionally, kidney function was improved, as reflected by reduced urea (17.30 ± 0.85) and creatinine (2.67 ± 0.23) compared to negative controls (34.53 ± 0.70 and 3.72 ± 0.45, respectively). Overall, the ethanol extract of A. senegalensis demonstrated hepatoprotective, nephroprotective, and lipid-regulating effects, highlighting its potential as a therapeutic agent for mitigating DEN-induced HCC and its associated metabolic complications.
Co-Authors Akafa Andes Tansaba Ingwu Joseph Akem Isaac John Umaru Khalid Yahuza Abbas Mosugu Ovayoza Omolara Ogar Fonne Okang Otashu Kenneth Frank Shadrach Philip Usman Ikira