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All Journal African Journal of Clinical Medicine and Pharmacy Research African Journal of Medicine, Surgery and Public Health Research
Queen Uyo Williams
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effect of Aqueous Hibiscus Sabdariffa on the Histology of the Testes of Male Albino Wistar Rats Charles Ayara; Williams Oche Ujah; Favour Joel Bafai; Victor Makanjuola; Kingsley Bassey Enang; Queen Uyo Williams; Tensaba Andes Akafa; Peter Ise Uduak; Isaac John Umaru
African Journal of Clinical Medicine and Pharmacy Research Vol 1 No 1 (2024): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v1i1.3974

Abstract

Medicinal plants contain physiological principles that over the years had been exploited in traditional medicine for the treatment of various ailments. Hibiscus Sabdariffa is not primarily a medicinal plant, but is used as alternative treatment to a wide variety of medical conditions. It is a plant of various psychoactive properties. This study investigated the histological effect of Hibiscus Sabdariffa aqueous solution on the testes of male albino rats. The research used 20 rats weighing 50-100g and were divided into Group A, Group B, Group C, Group D and Group E. Group A was the control group; unexposed to any form of Hibiscus Sabdariffa. Group B were exposed to the extract in a dosage of 0.5ml only in the morning. Group C were exposed to the extract in a dosage of 0.5ml in the morning and afternoon after (6) six hours. Group D were exposed to the extract in a dosage of 0.5ml in the morning, afternoon and by evening after six-hour intervals. Group E were exposed to the extract in an alternating administrative routine. In the end, the rats were sacrificed and the testes were removed and fixed in 10% formal saline solution. The testes were stained with hematoxylin and eosin. Results on the histology show changes to the histology of the testes of the group administered high doses. The results obtained from hormonal profiling shows a series of reduction in the levels of the evaluated hormones at the given dosage. Therefore, Hibiscus Sabdariffa can damage the histology of the testes at given dosage.
Histological Assessment of Aqueous Solution of Hibiscus sabariffa calyx (Zobo drink) on the Frontal Cortex and Hippocampus of Albino Wistar Rats Williams Oche Ujah; Ozzioma Praise Acha; Charles Ayara; Victor Makanjuola; Eric Agim Agaba; Queen Uyo Williams; Tensaba Andes Akafa; Isaac John Umaru
African Journal of Clinical Medicine and Pharmacy Research Vol 1 No 1 (2024): African Journal of Clinical Medicine and Pharmacy Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajcmpr.v1i1.3975

Abstract

Zobo drink which is consumed by many Nigerians, is a non-alcoholic beverage with phytoactive properties. This study investigated the histological outcome of Hibiscus sabdariffa calyx aqueous solution (Zobo drink) on the frontal cortex and hippocampus of albino wistar rats. Twenty (20) albino wistar rats were used, and grouped into a control group A, B, C, D and E. Group A was the control group. 0.5ml of Zobo drink was administered at different time interval to the experimental groups for 21 days. Zobo drink was administered to group B once a day, two times a day to group C, three times a day to group D and throughout the duration of administration to group E. In the end, the rats were sacrificed and the brain was removed and fixed in 10% formal saline solution. The frontal cortex and hippocampus were stained with Haematoxylin and eosin. Results show that no adverse effect on the frontal cortex of group B, C, D and E but shows effect on group E which is the high dose.
The Effect of Aqueous Solution of Hibiscus sabdariffa (Zobo Drink) on Albino Wistar Rats Ovarian Tissue Tensaba Andes Akafa; Williams Oche Ujah; Isaac Kogi Eli; Charles Ayara; Victor Makanjuola; Queen Uyo Williams; Dafup Katdel Istifanus; Vika Tensaba Akafa; Izam Emmanuel David; Kingsley Iyoko Iseko; Ranyang R. Akafa
African Journal of Medicine, Surgery and Public Health Research Vol 1 No 1 (2024): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v1i1.4011

Abstract

Hibiscus sabdarrifa is a flowering plant that grows in tropical regions. It is used in the preparation of a non-alcoholic beverage called Zobo drink. This current study investigated the ovarian histological changes and hormonal level outcome that occur after administration of Hibiscus sabdarrifa aqueous solution (Zobo drink) on albino Wistar rat. Twenty (20) female Wistar rats were purchased and divided into five (5) groups, group A, group B, group C, group D and group E with each group having four (4) Wistar rats. Group A, the control group was unexposed to any form of foreign substance. Group B were given 0.5ml of Zobo drink once daily (morning). Group C were given 0.5ml of Zobo drink twice daily (morning and afternoon). Group D were given 0.5ml of Zobo drink three times daily (morning, afternoon and evening). Group E were given the Zobo drink concurrently all through the day and water only at night. In the end, the rats were sacrificed and the ovaries were removed and fixed in 10% formalin saline solution. The ovaries were stained with hematoxylin and eosin. Their blood was collected through the femoral artery for hormonal level assay. The histological result of group A, B, C and D showed normal histological structures. Group E showed hemorrhage in the corpus luteum of the ovaries. The result of the hormonal analysis showed an increase in the level of progesterone, follicle stimulating hormone and luteinizing hormone and decrease in the level of estrogen all through the five groups. This lower estrogen level could impede menstruation. Therefore, Zobo drink can damage the ovary if taken in excess quantity and cause fluctuation in hormonal level of the ovary.
Co-Authors Charles Ayara Dafup Katdel Istifanus Eric Agim Agaba Favour Joel Bafai Isaac John Umaru Isaac Kogi Eli Izam Emmanuel David Kingsley Bassey Enang Kingsley Iyoko Iseko Ozzioma Praise Acha Peter Ise Uduak Ranyang R. Akafa Tensaba Andes Akafa Victor Makanjuola Vika Tensaba Akafa Williams Oche Ujah