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All Journal African Journal of Medicine, Surgery and Public Health Research
Ismail Yunusa Yuguda
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Assessment of Anti-Hepatitis B Virus Activity of Leaf Extract of Morinda Citrifolia Isaac John Umaru; Ismail Yunusa Yuguda; Ocheifa Mathew Ngbede; Kingsley Iyoko Iseko; Lubabatu Abdulrasheed; Tensaba Andes Akafa; Ameh Godwin Okwori
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 1 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i1.4593

Abstract

Hepatitis B virus infection remains a global health problem, it is a leading cause of liver disease and a possible worldwide source of severe morbidity and mortality. The current standard therapy using interferons or antiviral agents is not successful in all cases and is associated with severe side effects. Consequently, the development of new medicines for the treatment of HBV is still relevant. This experimental study was therefore performed to assess the anti-hepatitis B virus (HBV) potential of Leaf extract of Morinda citrifolia. The methanolic extracts of the Leaf extract of Morinda citrifolia first assessed for cytotoxicity on HepG2.2.15 cells and cytotoxicity concentration (CC50) values were resolved. The methanolic extracts of the Leaf extract of Morinda citrifolia was additionally examined on HepG2.2.15 cells for anti-HBV potential by examining the inhibition of HBsAg and HBeAg production in the culture supernatants, and calculating their half-maximum inhibitory concentration (IC50) and therapeutic index (TI) values. Out of four concentration only three exhibit inhibition of HBsAg production in an increasing dose and time dependent manner. These four concentrations are 100 μg/mL, 200 μg/mL, 300 μg/mL and 400 μg/mL, with IC50 values of 21.15, 24.51, 118.94, 17.65, 20.93 μg/mL, respectively. Moreover, the presence of terpenoids, tannins, alkaloids and flavonoids that could contribute to antiviral efficacy was validated with a qualitative phytochemical study of active extracts.
Co-Authors Ameh Godwin Okwori Isaac John Umaru Kingsley Iyoko Iseko Lubabatu Abdulrasheed Ocheifa Mathew Ngbede Tensaba Andes Akafa