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All Journal African Journal of Medicine, Surgery and Public Health Research
Lubabatu Abdulrasheed
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Assessment of Anti-Hepatitis B Virus Activity of Leaf Extract of Morinda Citrifolia Isaac John Umaru; Ismail Yunusa Yuguda; Ocheifa Mathew Ngbede; Kingsley Iyoko Iseko; Lubabatu Abdulrasheed; Tensaba Andes Akafa; Ameh Godwin Okwori
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 1 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i1.4593

Abstract

Hepatitis B virus infection remains a global health problem, it is a leading cause of liver disease and a possible worldwide source of severe morbidity and mortality. The current standard therapy using interferons or antiviral agents is not successful in all cases and is associated with severe side effects. Consequently, the development of new medicines for the treatment of HBV is still relevant. This experimental study was therefore performed to assess the anti-hepatitis B virus (HBV) potential of Leaf extract of Morinda citrifolia. The methanolic extracts of the Leaf extract of Morinda citrifolia first assessed for cytotoxicity on HepG2.2.15 cells and cytotoxicity concentration (CC50) values were resolved. The methanolic extracts of the Leaf extract of Morinda citrifolia was additionally examined on HepG2.2.15 cells for anti-HBV potential by examining the inhibition of HBsAg and HBeAg production in the culture supernatants, and calculating their half-maximum inhibitory concentration (IC50) and therapeutic index (TI) values. Out of four concentration only three exhibit inhibition of HBsAg production in an increasing dose and time dependent manner. These four concentrations are 100 μg/mL, 200 μg/mL, 300 μg/mL and 400 μg/mL, with IC50 values of 21.15, 24.51, 118.94, 17.65, 20.93 μg/mL, respectively. Moreover, the presence of terpenoids, tannins, alkaloids and flavonoids that could contribute to antiviral efficacy was validated with a qualitative phytochemical study of active extracts.
Antihypertensive Effects of Ethanol Stem-Bark Extract of Morinda Citrifolia in Rats Isaac John Umaru; Ameh Godwin Okwori; Ocheifa Mathew Ngbede; Lubabatu Abdulrasheed; Kingsley Iyoko Iseko; Tensaba Andes Akafa
African Journal of Medicine, Surgery and Public Health Research Vol 2 No 1 (2025): African Journal of Medicine, Surgery and Public Health Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajmsphr.v2i1.4594

Abstract

The medical term used for blood pressure is Hypertension (HTN). Hypertension is a common problem faced by most people today. The leading danger for many diseases such as CVD (cardiovascular) disorder and stroke is high blood pressure. Major diseases like CHF (congestive heart failure), renal disease and blindness can also be caused by HTN. Awareness of plant-based medication therapeutics is continuously increasing day by day. Morinda citrifolia L (Noni) has been used in folk remedies by Polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects. The purpose of this study is to investigate the hypotensive potential of Morinda citrifolia L (Noni) (Family: Rubiaceae) in both normotensive and hypertensive rats. Methods: Aqueous-methanol (70:30) extract of Morinda citrifolia L stem-bark extract at doses of 25, 50, 75 and 100 mg/kg was evaluated for its effect on blood pressure and heart rate using non-invasive blood pressure measuring apparatus. After initial screening, 100 mg/kg dose that produced a maximum effect was selected for the antihypertensive study. Median lethal dose (LD50) and sub-chronic toxicity of the extract were also determined. Various biochemical parameters and organ weight were measured using standard procedures. Results: The extract produced a significant (p < 0.01) decrease in systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP) and heart rate of normotensive rats at all test doses with maximum effect at 100 mg/kg. Similarly, a significant antihypertensive and negative chronotropic effect was observed in both hypertensive models. LD50 of the extract was 200 mg/kg in mice. The extract also exhibited a reduction (p < 0.05) in serum alanine transaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), triglycerides and low-density lipoprotein (LDL) levels while a significant (p < 0.05) increase in high density lipoproteins (HDL) level was observed. Conclusion: It seems that the aqueous-methanol stem-bark extract of Morinda citrifolia L possesses active compounds which may be responsible for the antihypertensive and negative chronotropic effects in rats.
Co-Authors Ameh Godwin Okwori Isaac John Umaru Ismail Yunusa Yuguda Kingsley Iyoko Iseko Ocheifa Mathew Ngbede Tensaba Andes Akafa