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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Public Health and Pharmacy Journal of Food and Pharmaceutical Sciences
Nanik Sulistyani
Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Formulation and Evaluation of a Sunscreen Spray Containing Butterfly Pea Flower (Clitoria ternatea) Extract as a Natural Antioxidant Nyoman Rudi Kusuma; Nanik Sulistyani; Nining Sugihartini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31747

Abstract

Butterfly pea flower (Clitoria ternatea) is rich in anthocyanins with recognized antioxidant activity; however, its application in spray-based sunscreen formulations and its effect on photoprotective performance remain insufficiently explored. This study aimed to formulate and evaluate a sunscreen spray containing butterfly pea extract (BPE) in combination with ethylhexyl methoxycinnamate and to determine the optimal extract concentration based on antioxidant activity, SPF value, and formulation stability. Five formulations were prepared: F0 (without BPE), F1 (0% BPE + 0.8% BHT), and F2–F4 containing 1%, 2%, and 3% BPE, respectively. Evaluations included DPPH radical scavenging activity, SPF determination, antibacterial testing, and physical quality assessment. The antioxidant activity of BPE in spray formulations showed moderate activity, with IC₅₀ values of 90.53±1.0, 87.50±1.9, and 86.94±1.4 μg/mL for 1%, 2%, and 3% concentrations, respectively, compared to 49.90±0.9 μg/mL for the pure extract. Although the antioxidant activity in formulations was lower than the pure extract due to dilution effects, increasing BPE concentration significantly improved SPF values (27.36±2.7; 29.42±1.1; 31.98±0.9; p<0.05). No significant difference was observed between 2% and 3% concentrations in both antioxidant and SPF evaluations. Therefore, 2% BPE was considered the optimal concentration, offering comparable efficacy with improved material efficiency for potential industrial production. All formulations met acceptable physical quality parameters, while antibacterial activity was not observed. This study demonstrates the feasibility of incorporating C. ternatea extract into sunscreen spray systems and provides a scientific basis for developing plant-based antioxidant-enhanced photoprotective formulations.
Evaluation of Herbal Honey with Black Cumin and Curcuma xanthorriza as an Antioxidant Supplement for Stunting Prevention Lukman Hardia; Akrom Akrom; Titiek Hidayati; Nanik Sulistyani
Journal of Public Health and Pharmacy Vol. 5 No. 1 (2025)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i1.5549

Abstract

Introduction: Honey has been widely used as a nutritional supplement and medicine. Many herbal honey products are developed as nutritional supplements that are combined with SFM to make them more effective, but there are still many shortcomings due to the unpleasant taste produced, unattractive physical appearance, and high susceptibility to oxidation reactions that cause severe damage to the quality of honey, especially in the content of active substances, viscosity, and pH, which can cause the effectiveness of honey to decrease and result in product failure as nutritional supplements to treat stunting problems. We have developed an herbal honey multi-nutrient supplement that combines honey with black cumin oil and Curcuma xanthorriza extract called HBCX. Adding Curcuma xanthorriza extract and black cumin oil to honey is expected to increase honey's benefits as an antioxidant. This study aims to determine the physicochemical characteristics (pH and viscosity), heavy metal contamination content, polyphenols, and antioxidant activity. Methods: This experimental laboratory research was conducted at the Pharmacy Lab, Faculty of Pharmacy, UAD. The viscosity and pH of HBCX were observed using an Ostwald viscometer and a pH meter. Total phenol determined by Folin-Ciocalteau reagent and gallic acid standard. Determination of antioxidant activity using the DPPH method. The data are presented in a quantitative descriptive manner and matched with the SNI honey standard. Results: The results showed that HBCX herbal honey had a higher viscosity than the sampled honey from the market but was still lower than the SNI requirements. HBCX honey has a lower pH than sample honey products from the market but still complies with national standards. HBCX honey is safe from heavy metal contamination and contains polyphenols. The antioxidant activity of HBCX honey is relatively high, with IC50=54.78 ppm. Conclusion: HBCX has high polyphenol content, is safe from heavy metal contamination, and has sufficient antioxidant activity.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Faisal Nur Arib; Kintoko Kintoko; Nanik Sulistyani; Akrom Akrom
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended.
Co-Authors Akrom Akrom Akrom, Akrom Faisal Nur Arib Kintoko Kintoko Lukman Hardia Nining Sugihartini Nyoman Rudi Kusuma Titiek Hidayati