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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Sains dan Teknologi
Vera Estefania Kaban
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Perbandingan Ektrak Konvensional dengan Green Ektraksi Umbi Porang (Amorphophallus Muelleri) terhadap Aktivitas Antioksidan Pasti Marito Samosir; Roy Indrianto Bangar; Vera Estefania Kaban
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7536

Abstract

Porang tuber (Amorphophallus muelleri) contains various bioactive compounds with potential antioxidant activity, while extraction efficiency is strongly influenced by the applied method. This study aimed to compare conventional and environmentally friendly extraction techniques, including maceration, Soxhlet extraction, Microwave-Assisted Extraction (MAE), and Ultrasonic-Assisted Extraction (UAE), using 70% ethanol as the solvent. Antioxidant activity was evaluated using the DPPH radical scavenging assay and expressed as IC₅₀ values. The results showed that differences in extraction methods significantly affected antioxidant activity. Soxhlet extraction exhibited the highest antioxidant activity with the lowest IC₅₀ value (0.1788 µg/mL), followed by MAE (0.4312 µg/mL), maceration (0.6315 µg/mL), and UAE (0.6574 µg/mL). The superiority of the Soxhlet method is related to continuous solvent reflux and heat-assisted mass transfer, which enhance the release of antioxidant compounds. These findings confirm that porang tuber is a promising natural antioxidant source, with Soxhlet extraction identified as the most effective method under the applied experimental conditions for future development of functional food, nutraceutical, and pharmaceutical applications.
Uji Aktivitas Antijamur Nanopartikel Zink Oksida (ZnO) Ekstrak Kulit Jengkol terhadap Candida Albicans Ica Dwi Patricia; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7539

Abstract

Natural materials are increasingly being used as sources of bioactive chemicals due to increased concerns about safety, sustainability, and environmental effect. Jengkol peel is one such natural material with potential because it contains various secondary metabolites compounds that have biological activity. On the other hand, Candida albicans fungal infections remain a health problem, while conventional antifungal options are limited and have the potential to cause side effects. Zinc oxide (ZnO) nanoparticles are known to have broad antimicrobial activity, and their synthesis can be carried out in an environmentally friendly manner through a green synthesis approach using natural materials. This study aims to test the antifungal activity of ZnO nanoparticles synthesized using jengkol peel extract against Candida albicans. The study was conducted experimentally. Antifungal activity was tested using the well diffusion method with various concentrations of ZnO nanoparticles. The results showed the formation of an inhibition zone around the well, indicating the antifungal activity of ZnO nanoparticles. The increase in ZnO nanoparticle concentration is directly proportional to the increase in inhibition zone diameter, with the highest inhibition of 14 mm categorized as moderate activity. This study proves that jengkol-based ZnO nanoparticles have the potential to be developed as an environmentally friendly alternative antifungal agent.
Formulasi dan Evaluasi Sediaan Topikal Nanogel Daun Kipahit (Tithonia diversifolia) dan aktivitas sebagai Antimikroba Faza Fauzan Azima; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 3 (2026): Juni 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i3.8202

Abstract

Candida albicans is a fungal microorganism that can cause candidiasis and requires the development of alternative therapies derived from natural products. Bitter leaf (Tithonia diversifolia) contains bioactive compounds such as flavonoids, alkaloids, and tannins that have potential antifungal activity. This study aimed to formulate and evaluate a nanogel containing ethanol extract of Tithonia diversifolia leaves and to assess its antifungal activity against Candida albicans. The extract was obtained through maceration using 70% ethanol and formulated into nanogels using a modified emulsification-diffusion method at concentrations of 5%, 10%, and 15%. The formulations were evaluated for organoleptic properties, homogeneity, pH, spreadability, viscosity, particle size, and antifungal activity using the agar well diffusion method. The results showed that all nanogel formulations exhibited good physical characteristics and met the requirements for topical application. Particle size analysis revealed sizes ranging from 755.75 to 847.29 nm, indicating that all formulations met the criteria for nanoparticulate systems. All formulations demonstrated inhibitory activity against the growth of Candida albicans, with inhibition tending to increase as the extract concentration increased. The incorporation of bitter leaf extract into a nanogel system may improve the stability and delivery of bioactive compounds compared with conventional formulations. Therefore, the ethanol extract nanogel of Tithonia diversifolia leaves has the potential to be developed as a natural-based topical antifungal formulation.
Aktivitas Antijamur Nanopartikel Zinc Oxide (ZnO) yang Disintesis Menggunakan Ekstrak Kulit Buah Duku (Lansium domesticum) Mutiara Ihsani; Vera Estefania Kaban; Razoki Lubis
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7800

Abstract

This study evaluated zinc oxide (ZnO) nanoparticles biosynthesized using an aqueous extract of duku (Lansium domesticum Corr Corr.) fruit peel for their antifungal activity against Candida albicans, given the rising incidence of candidiasis and the growing resistance to conventional antifungal drugs. The synthesized ZnO nanoparticles were characterized by particle size analysis, showing a Z-average diameter of 89 nm and a polydispersity index of 0.243, confirming their nanoscale dimension and reasonably uniform size distribution. Antifungal activity was assessed using the agar well diffusion method at concentrations of 25-500%. ZnO nanoparticles inhibited Candida albicans growth at every concentration tested, with inhibition zone diameters increasing proportionally with concentration, from 9.65 ± 0.28 mm (moderate category) at 25% to 15.33 ± 0.11 mm (strong category) at 500%, compared with 31.86 mm for the ketoconazole positive control. One-way ANOVA confirmed significant differences among treatment concentrations (F = 397.795; p < 0.001). These findings indicate that green-synthesized ZnO nanoparticles from duku peel extract exhibit concentration-dependent antifungal activity against Candida albicans , supporting their potential as an environmentally friendly alternative antifungal agent.
Co-Authors Astriani Natalia Br Ginting Faza Fauzan Azima Ica Dwi Patricia Mutiara Ihsani Pasti Marito Samosir Razoki Lubis Roy Indrianto Bangar