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All Journal Jurnal Sains dan Teknologi Jurnal Kesehatan Amanah Journal of Pharmaceutical and Sciences. Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Astriani Natalia Br Ginting
Universitas Prima Indonesia
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Uji Aktivitas Antijamur Nanopartikel Zink Oksida (ZnO) Ekstrak Kulit Jengkol terhadap Candida Albicans Ica Dwi Patricia; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7539

Abstract

Natural materials are increasingly being used as sources of bioactive chemicals due to increased concerns about safety, sustainability, and environmental effect. Jengkol peel is one such natural material with potential because it contains various secondary metabolites compounds that have biological activity. On the other hand, Candida albicans fungal infections remain a health problem, while conventional antifungal options are limited and have the potential to cause side effects. Zinc oxide (ZnO) nanoparticles are known to have broad antimicrobial activity, and their synthesis can be carried out in an environmentally friendly manner through a green synthesis approach using natural materials. This study aims to test the antifungal activity of ZnO nanoparticles synthesized using jengkol peel extract against Candida albicans. The study was conducted experimentally. Antifungal activity was tested using the well diffusion method with various concentrations of ZnO nanoparticles. The results showed the formation of an inhibition zone around the well, indicating the antifungal activity of ZnO nanoparticles. The increase in ZnO nanoparticle concentration is directly proportional to the increase in inhibition zone diameter, with the highest inhibition of 14 mm categorized as moderate activity. This study proves that jengkol-based ZnO nanoparticles have the potential to be developed as an environmentally friendly alternative antifungal agent.
Potensi Aktivitas Antibakteri Antara Ekstrak dan Fraksi Kulit Jeruk Terhadap Ulkus Diabetes Farren Farren; Rena Meutia; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Kesehatan Amanah Vol. 9 No. 1 (2025): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v9i1.765

Abstract

Diabetic ulcers, a chronic complication of diabetes mellitus, result from long-term uncontrolled blood sugar levels and are characterised by infection-prone foot wounds. Staphylococcus aureus is often found as the bacteria that cause infection in these wounds. Antibiotic resistance has become a serious challenge in medicine, so alternatives such as orange peel (Citrus sinensis (L.) Osbeck) were investigated for their metabolite content with antibacterial potential. This study was designed experimentally with a Posttest Only Control Group Design approach. Orange peels were processed through sorting, drying, extraction using 96% ethanol, and fractionation with ethyl acetate. Antibacterial activity test was conducted by disc method against Staphylococcus aureus, using ethanol extract and ethyl acetate fraction. DMSO and mupirocin were used as negative and positive controls, with concentrations of 25%, 50%, and 75%. The results showed that the ethanol extract had antibacterial activity, with a concentration of 75% producing the largest inhibition zone (13.56 mm), including the medium category. However, the ethyl acetate fraction did not show antibacterial activity at all concentrations, presumably due to the low levels of extractable semipolar metabolites. Environmental factors such as UV light, humidity, and high temperature during drying are also thought to affect metabolite levels. It was concluded that ethanol extract of orange peel was more effective than ethyl acetate fraction in inhibiting the growth of Staphylococcus aureus.
Pengembangan Seedian Emulgel Kombinasi Fraksi Aktif Daun Kersen dan Kulit Kayu Manis Untuk Ulkus Diabetikum Brigita Julianti Manalu; Novitaria Br Sembiring; Astriani Natalia Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1361

Abstract

Introduction: Diabetic ulcer is a serious complication of diabetes mellitus that is often accompanied by bacterial infections, necessitating effective topical therapy. Kersen leaves (Muntingia calabura L.) and cinnamon bark (Cinnamomum sp.) are known to contain bioactive compounds with antibacterial potential. Aim: This study aims to develop and evaluate the antibacterial activity of an emulgel formulation containing a combination of active fractions from kersen leaves and cinnamon bark as a candidate for topical therapy for diabetic ulcers. Method: The active fractions were obtained through extraction and fractionation processes, then formulated into an emulgel at varying concentrations of 10%, 30%, 50%, 60%, and 70%. Antibacterial activity was tested against Staphylococcus aureus using the agar disk diffusion method, with clindamycin as a positive control and the emulgel base as a negative control. Result: The results showed that the emulgel began to exhibit antibacterial activity at a concentration of 50%, with an average inhibition zone diameter of 12.96 mm. Increasing the concentration to 60% and 70% enhanced the inhibition zones to 14.00 mm and 15.24 mm, respectively. Clindamycin produced an inhibition zone of 29.57 mm, while the negative control showed no inhibitory activity. Conclusion: The emulgel combination of active fractions from kersen leaves and cinnamon bark possesses concentration-dependent antibacterial activity and has the potential to be developed as a topical herbal preparation to support diabetic ulcer therapy.
Uji Total Flavonoid dan Aktivitas Antioksidan Fraksi Daun Brotowali sebagai Diabetes Ulkus Jhon Evan Iskandar Manullang; Novitaria Br Sembiring; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i2.7866

Abstract

Diabetic ulcers are a chronic complication of diabetes mellitus characterized by impaired wound healing due to increased oxidative stress. One therapeutic approach that can be developed is the use of medicinal plants with antioxidant activity, such as Tinospora crispa leaves (Tinospora crispa), which contain flavonoids. This study aimed to determine the total flavonoid content and antioxidant activity of Tinospora crispa leaf fractions. Extraction was carried out using 96% ethanol, followed by fractionation using n-hexane, ethyl acetate, and water. Flavonoid content was determined using UV-Vis spectrophotometry using quercetin as a standard at a wavelength of 430.5 nm, while antioxidant activity was tested using the DPPH method. The results showed that the Tinospora crispa leaf aqueous fraction contained flavonoids of 0.2179 mg QE/g, with a linear calibration curve (R² = 0.997). Furthermore, the aqueous fraction demonstrated very strong antioxidant activity with an IC₅₀ value of ±16 µg/mL. Based on these results, the water fraction of brotowali leaves has the potential to be a source of natural antioxidants that can support the healing of diabetic ulcers by suppressing oxidative stress.
Aktivitas Nano Spray Gel Ekstrak Kulit Nanas (Ananas comosus L.) terhadap Pertumbuhan Bakteri Staphylococcus epidermidis pada Ulkus Diabetes Melitus Secara In Vitro Jesiska Muaratan; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.659

Abstract

Diabetic ulcers are complications of diabetes mellitus often associated with bacterial infections like Staphylococcus epidermidis. Pineapple peel is rich in secondary metabolites including flavonoids with potential antibacterial effects. This study aimed to assesss the antibacterial activity of nano spray gel made with pineapple peel extract against Staphylococcus epidermidis through in vitro testing. This research employed a laboratory experimental design using nano spray gel formulations at varying concentrations of 25%, 50%, and 75% of pineapple peel extract. Flavonoids, alkaloids, tannins, and saponins are confirmed by phytochemical analysis. Only the formulation with 75% demonstrated antibacterial activity effect, with an average inhibition zone of 8.61 mm (medium category). 25% and 50% formulations show no inhibition. Pure extract showed a 15.42 mm zone (strong), while the positive control (clindamycin) produced 29.69 mm (very strong) inhibition zone. PSA results indicated particle size averaged 1480 nm, exceeding the nanoemulsion standard (<500 nm). Nano spray gel with 75% pineapple peel extract demonstrated antibacterial activity against S. epidermidis, although the particle size did not meet nanoemulsion criteria.
Formulasi dan Evaluasi Sediaan Topikal Nanogel Daun Kipahit (Tithonia diversifolia) dan aktivitas sebagai Antimikroba Faza Fauzan Azima; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 3 (2026): Juni 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i3.8202

Abstract

Candida albicans is a fungal microorganism that can cause candidiasis and requires the development of alternative therapies derived from natural products. Bitter leaf (Tithonia diversifolia) contains bioactive compounds such as flavonoids, alkaloids, and tannins that have potential antifungal activity. This study aimed to formulate and evaluate a nanogel containing ethanol extract of Tithonia diversifolia leaves and to assess its antifungal activity against Candida albicans. The extract was obtained through maceration using 70% ethanol and formulated into nanogels using a modified emulsification-diffusion method at concentrations of 5%, 10%, and 15%. The formulations were evaluated for organoleptic properties, homogeneity, pH, spreadability, viscosity, particle size, and antifungal activity using the agar well diffusion method. The results showed that all nanogel formulations exhibited good physical characteristics and met the requirements for topical application. Particle size analysis revealed sizes ranging from 755.75 to 847.29 nm, indicating that all formulations met the criteria for nanoparticulate systems. All formulations demonstrated inhibitory activity against the growth of Candida albicans, with inhibition tending to increase as the extract concentration increased. The incorporation of bitter leaf extract into a nanogel system may improve the stability and delivery of bioactive compounds compared with conventional formulations. Therefore, the ethanol extract nanogel of Tithonia diversifolia leaves has the potential to be developed as a natural-based topical antifungal formulation.
Co-Authors Asyrun Alkhairi Lubis Brigita Julianti Manalu Farren Farren Faza Fauzan Azima Ica Dwi Patricia Jesiska Muaratan Jhon Evan Iskandar Manullang Nerly Juli Pranita Simanjuntak Novitaria Br Sembiring Novitaria Br Sembiring Rena Meutia Vera Estefania Kaban