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All Journal Jurnal Pelayanan dan Pengabdian Kesehatan untuk Masyarakat Borneo Journal of Pharmacy
Catherina Adeline Kurniawan
Universitas Lambung Mangkurat
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Upaya Pencegahan Resistensi Antibiotik Melalui Edukasi Antibiotik di Klinik Kimia Farma Pramuka Banjarmasin Catherina Adeline Kurniawan; Fitrian Desmana; Khairunnida Khairunnida; Okta Muthia Sari; Ester Novella br Tobing; Muhammad Andin; Dwi Aulina; Hastuti Hastuti
Jurnal Pelayanan dan Pengabdian Kesehatan untuk Masyarakat Vol 3, No 4 (2026): Jurnal Pelayanan dan Pengabdian Kesehatan Untuk Masyarakat
Publisher : Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/jppkm.v3i4.8289

Abstract

Antibiotic resistance is a significant issue in the area of antibiotic use. The rise in antibiotic consumption across various sectors of healthcare and agriculture risks leading to the development of antibiotic resistance. This health education program aims to increase the knowledge of visitors to the Kimia Farma Pramuka Banjarmasin Clinic with information about the dangers of antibiotic resistance, its prevention, and the principles of proper antibiotic use. The health education program utilizes a lecture method. The target participants of this health education program are visitors in the waiting room of the Kimia Farma Pramuka Banjarmasin Clinic on January 16, 2025. The health education materials used are leaflets. The success of the health promotion was evaluated by measuring the participants' knowledge before and after the health education program. This activity was attended by 19 participants and ran smoothly. The results of the measurement of the participants' initial knowledge showed an average score of 34.74%. Then, the participants' final knowledge was measured, with an average score of 90.53%. Conclusion: the knowledge of visitors to the Kimia Farma Pramuka Banjarmasin Clinic increased by 55.79% after education about the dangers of antibiotic resistance, its prevention, and the principles of proper antibiotic use.
In Silico Evaluation of Kaempferol, Gallic Acid, and Stigmasterol from Lagerstroemia speciosa as Multi-Target Antidiabetic Agents: Molecular Docking and Dynamics Simulation Study Aditya Maulana Perdana Putra; Catherina Adeline Kurniawan; Anna Khumaira Sari; Nabila Hadiah Akbar; Khoirunnisa Muslimawati; Okta Muthia Sari; Dita Ayulia Dwi Sandi; Normaidah Normaidah; Putri Helena Junjung Buih; Ariranur Haniffadli
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.9720

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that leads to severe complications and continues to increase in prevalence worldwide. Although Lagerstroemia speciosa is a well-recognized antidiabetic medicinal plant, most in silico studies have focused exclusively on its major constituent, leaving the antidiabetic potential of its other phytochemicals largely unexplored. This study investigated the multi-target antidiabetic potential of phytochemicals derived from L. speciosa leaves using an in silico approach targeting three key enzymes: aldose reductase, glucokinase, and glycogen synthase kinase 3-beta (GSK3-β). A total of 62 compounds were screened by molecular docking with AutoDock Vina, followed by toxicity predictions using ProTox-II and ToxTree. The top ligand for each target, kaempferol (aldose reductase), gallic acid (glucokinase), and stigmasterol (GSK3-β), was selected for further evaluation through molecular dynamics simulations using GROMACS 2016.3 for 100 ns. Structural and interaction stability were assessed through RMSD, RMSF, SASA, radius of gyration (Rg), and radial distribution function (RDF) analyses. Binding free energies were calculated using the MM/PBSA method via g_mmpbsa. The results indicated that stigmasterol exhibited the most favorable MM/PBSA binding free energy (–133.377 kJ/mol), followed by kaempferol (–65.714 kJ/mol) and gallic acid (–45.629 kJ/mol). However, this favorable energy was dominated by nonspecific van der Waals contributions, consistent with the diffuse interaction patterns and low hydrogen-bond occupancy (4.24%) for stigmasterol. Kaempferol exhibited the highest hydrogen-bond occupancy (64.38%), indicating a stable, consistent interaction with its target enzyme. Rg and RDF analyses confirmed the compactness and specific atomic interactions of the kaempferol and gallic acid complexes.
Co-Authors Anna Khumaira Sari Ariranur Haniffadli Buih, Putri Helena Junjung Dwi Aulina Ester Novella br Tobing Fitrian Desmana Hastuti Hastuti Khairunnida Khairunnida Khoirunnisa Muslimawati Muhammad Andin Nabila Hadiah Akbar Normaidah, Normaidah Okta Muthia Sari Putra, Aditya Maulana Perdana Sandi, Dita Ayulia Dwi